Lyell Immunopharma
Senior Director, Medical Affairs, Solid Tumors
Lyell Immunopharma, California, Missouri, United States, 65018
Senior Director, Medical Affairs, Solid Tumors
Lyell Immunopharma is a clinical‑stage company advancing next‑generation CAR T‑cell therapies for solid tumors and hematologic malignancies. With a fully integrated pipeline and a culture built on science, respect, collaboration, and courage, we are committed to translating breakthrough science into life‑changing therapies. This fully remote position provides an opportunity to lead medical affairs strategy for solid tumor programs, starting with metastatic colorectal cancer (mCRC). KEY ROLE AND RESPONSIBILITIES
Strategic Leadership & Program
Serve as Lyell’s Medical Affairs lead for mCRC and future solid tumor programs, providing deep disease‑area expertise and independent strategic direction. Partner with the SVP and VP, Medical Affairs to shape and evolve the overall vision for Medical Affairs. Lead the development and execution of medical strategy for solid tumors, aligned with corporate, clinical, and regulatory objectives. Shape medical narrative, scientific platform, core claims, and evidence‑generation needs to support evolving program priorities. Drive Medical Affairs contributions to launch readiness for solid tumor assets.
External Engagement
Build and maintain strong professional relationships with KOLs, investigators, and academic centers within the GI oncology and solid tumor communities. Represent Lyell at key scientific congresses (e.g., ASCO, ESMO, GI ASCO) and advisory boards to facilitate scientific exchange. Gather and synthesize external insights to shape Medical Affairs initiatives and support clinical development priorities.
Medical Excellence & Communications
Oversee the development of medical narratives, scientific platforms, and publication strategy for the solid tumor portfolio. Ensure compliant, high‑quality execution of medical communication initiatives and educational materials relevant to the colorectal cancer program. Provide scientific training and guidance to internal teams and field medical staff to ensure consistency and accuracy of scientific messaging.
Leadership & Governance
Demonstrate independent leadership in managing projects, resources, and potential direct reports or cross‑functional teams to meet program deliverables. Ensure all Medical Affairs activities within the solid tumor program comply with legal, regulatory, and corporate standards. Contribute to the development of governance frameworks and authorship policies as a senior member of the Medical Affairs team.
PREFERRED EDUCATION & EXPERIENCE
MD, DO, PharmD, or PhD required. Oncology specialty required; specific background in GI oncology or solid tumors strongly preferred. Minimum 8–10 years of pharmaceutical/biotech industry experience, with 5+ years in Medical Affairs. Extensive experience in oncology is required; prior experience in metastatic colorectal cancer, cell therapy, or immuno‑oncology is highly desirable. Proven track record of independently leading medical strategy for a specific asset or therapeutic area. Strong knowledge of U.S. compliance and regulatory requirements applicable to Medical Affairs. Launch experience strongly preferred. KNOWLEDGE, SKILLS AND ABILITIES
Strong scientific expertise in oncology, with the ability to analyze, interpret, and communicate complex scientific data. Exceptional interpersonal and communication skills; comfortable engaging with external experts and internal senior leaders. Strong strategic acumen and ability to drive multiple concurrent initiatives. Demonstrated leadership without formal authority; ability to mentor future Medical Affairs team members. Ability to operate effectively in a fast‑paced, high‑growth biotech environment with limited infrastructure. Ability to effectively collaborate with and influence cross‑functional stakeholders at senior levels. COMPENSATION & BENEFITS
The salary range for this position is $250,000 to $300,000 annually, with the opportunity to earn an annual bonus. Employees are also eligible to participate in Lyell’s Equity Incentive Plan. Our Employee Benefits program is extensive and includes subsidized medical, dental and vision plans from day one of employment, FSA, company‑provided life and AD&D insurance, STD and LTD insurance, ESPP, a 401(k) plan with company match, mass transit commuter benefits, cell phone reimbursement and a range of supplemental benefits. Paid time‑off benefits currently include 18 vacation days, 9 sick days, 8 observed holidays and a floating holiday. We also have a summer and a winter office shutdown. We believe in building an open, diverse and inclusive culture for all employees. Lyell is proud to be an equal opportunity employer and does not discriminate on the basis of race, color, citizenship status, national origin, ancestry, sex, sexual orientation, age, religion, creed, physical or mental disability, medical condition, marital status, veteran status or any other characteristics protected under applicable federal, state and local laws.
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Lyell Immunopharma is a clinical‑stage company advancing next‑generation CAR T‑cell therapies for solid tumors and hematologic malignancies. With a fully integrated pipeline and a culture built on science, respect, collaboration, and courage, we are committed to translating breakthrough science into life‑changing therapies. This fully remote position provides an opportunity to lead medical affairs strategy for solid tumor programs, starting with metastatic colorectal cancer (mCRC). KEY ROLE AND RESPONSIBILITIES
Strategic Leadership & Program
Serve as Lyell’s Medical Affairs lead for mCRC and future solid tumor programs, providing deep disease‑area expertise and independent strategic direction. Partner with the SVP and VP, Medical Affairs to shape and evolve the overall vision for Medical Affairs. Lead the development and execution of medical strategy for solid tumors, aligned with corporate, clinical, and regulatory objectives. Shape medical narrative, scientific platform, core claims, and evidence‑generation needs to support evolving program priorities. Drive Medical Affairs contributions to launch readiness for solid tumor assets.
External Engagement
Build and maintain strong professional relationships with KOLs, investigators, and academic centers within the GI oncology and solid tumor communities. Represent Lyell at key scientific congresses (e.g., ASCO, ESMO, GI ASCO) and advisory boards to facilitate scientific exchange. Gather and synthesize external insights to shape Medical Affairs initiatives and support clinical development priorities.
Medical Excellence & Communications
Oversee the development of medical narratives, scientific platforms, and publication strategy for the solid tumor portfolio. Ensure compliant, high‑quality execution of medical communication initiatives and educational materials relevant to the colorectal cancer program. Provide scientific training and guidance to internal teams and field medical staff to ensure consistency and accuracy of scientific messaging.
Leadership & Governance
Demonstrate independent leadership in managing projects, resources, and potential direct reports or cross‑functional teams to meet program deliverables. Ensure all Medical Affairs activities within the solid tumor program comply with legal, regulatory, and corporate standards. Contribute to the development of governance frameworks and authorship policies as a senior member of the Medical Affairs team.
PREFERRED EDUCATION & EXPERIENCE
MD, DO, PharmD, or PhD required. Oncology specialty required; specific background in GI oncology or solid tumors strongly preferred. Minimum 8–10 years of pharmaceutical/biotech industry experience, with 5+ years in Medical Affairs. Extensive experience in oncology is required; prior experience in metastatic colorectal cancer, cell therapy, or immuno‑oncology is highly desirable. Proven track record of independently leading medical strategy for a specific asset or therapeutic area. Strong knowledge of U.S. compliance and regulatory requirements applicable to Medical Affairs. Launch experience strongly preferred. KNOWLEDGE, SKILLS AND ABILITIES
Strong scientific expertise in oncology, with the ability to analyze, interpret, and communicate complex scientific data. Exceptional interpersonal and communication skills; comfortable engaging with external experts and internal senior leaders. Strong strategic acumen and ability to drive multiple concurrent initiatives. Demonstrated leadership without formal authority; ability to mentor future Medical Affairs team members. Ability to operate effectively in a fast‑paced, high‑growth biotech environment with limited infrastructure. Ability to effectively collaborate with and influence cross‑functional stakeholders at senior levels. COMPENSATION & BENEFITS
The salary range for this position is $250,000 to $300,000 annually, with the opportunity to earn an annual bonus. Employees are also eligible to participate in Lyell’s Equity Incentive Plan. Our Employee Benefits program is extensive and includes subsidized medical, dental and vision plans from day one of employment, FSA, company‑provided life and AD&D insurance, STD and LTD insurance, ESPP, a 401(k) plan with company match, mass transit commuter benefits, cell phone reimbursement and a range of supplemental benefits. Paid time‑off benefits currently include 18 vacation days, 9 sick days, 8 observed holidays and a floating holiday. We also have a summer and a winter office shutdown. We believe in building an open, diverse and inclusive culture for all employees. Lyell is proud to be an equal opportunity employer and does not discriminate on the basis of race, color, citizenship status, national origin, ancestry, sex, sexual orientation, age, religion, creed, physical or mental disability, medical condition, marital status, veteran status or any other characteristics protected under applicable federal, state and local laws.
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