GlaxoSmithKline
Principal Downstream Scientist - mRNA purification
GlaxoSmithKline, Cambridge, Massachusetts, us, 02140
Principal Downstream Scientist – mRNA Purification
At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting‑edge technology to transform people’s lives.
About the Role As a Principal Downstream Scientist specializing in mRNA purification, you will play a key role in advancing innovative vaccine platforms. You will design and optimize purification processes, collaborate with cross‑functional teams, and contribute to the development of scalable solutions. This role is based in the United States.
Key Responsibilities
Design, execute, and analyze experiments to develop and optimize mRNA purification processes.
Ensure processes are scalable and phase‑appropriate for clinical manufacturing.
Collaborate with global teams, including analytical R&D, GMP, and process development colleagues.
Drive innovative solutions to improve purification techniques and meet project milestones.
Stay current with industry trends and emerging technologies in downstream processing.
Maintain detailed documentation to ensure data integrity and compliance.
Basic Qualifications
Master’s or PhD degree in Molecular Biology, Biotechnology, Bioengineering, Chemical Engineering, or a related field.
Five years (Master's) or Three years (PhD) of industry experience in downstream process development for large biomolecules, including mRNA or pDNA.
Hands‑on experience with purification techniques such as affinity capture, ion exchange, and hydrophobic interactions.
Three years of experience supporting CMC activities, including process and analytical development.
Preferred Qualifications
PhD in Molecular Biology, Biotechnology, Bioengineering, Chemical Engineering, or a related field.
Experience with Quality by Design principles and DOE studies for process optimization.
Knowledge of regulatory guidelines (FDA/ICH/ISPE) for process validation and technology transfer.
Familiarity with nucleic acid analytical technologies.
Strong problem‑solving skills and ability to work collaboratively in a matrixed environment.
Compensation If you are based in Cambridge, MA; Waltham, MA; Rockville, MD; or San Francisco, CA, the annual base salary for new hires in this position ranges from $113,025 to $188,375. This range reflects factors such as location, skills, experience, education, and market rate. In addition, the position offers an annual bonus and eligibility to participate in our share‑based long‑term incentive program. Available benefits include health care and other insurance benefits (for employees and families), retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave.
Benefits Summary Please visit
GSK US Benefits Summary
to learn more about the comprehensive benefits program GSK offers US employees.
Why GSK? Uniting science, technology, and talent to get ahead of disease together. GSK is a global biopharma company with a purpose to unite science, technology, and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases – to impact health at scale.
People and patients around the world count on the medicines and vaccines we make, so we’re committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.
Equal Opportunity Statement GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.
Additional Information Our recruitment team may contact you for adjustments or further assistance. If your inquiry does not relate to adjustments, we will not be able to support you through these channels. You can find answers to many common questions in our Recruitment FAQ guide.
For more information, visit the Centers for Medicare & Medicaid Services website at https://openpaymentsdata.cms.gov/.
#J-18808-Ljbffr
About the Role As a Principal Downstream Scientist specializing in mRNA purification, you will play a key role in advancing innovative vaccine platforms. You will design and optimize purification processes, collaborate with cross‑functional teams, and contribute to the development of scalable solutions. This role is based in the United States.
Key Responsibilities
Design, execute, and analyze experiments to develop and optimize mRNA purification processes.
Ensure processes are scalable and phase‑appropriate for clinical manufacturing.
Collaborate with global teams, including analytical R&D, GMP, and process development colleagues.
Drive innovative solutions to improve purification techniques and meet project milestones.
Stay current with industry trends and emerging technologies in downstream processing.
Maintain detailed documentation to ensure data integrity and compliance.
Basic Qualifications
Master’s or PhD degree in Molecular Biology, Biotechnology, Bioengineering, Chemical Engineering, or a related field.
Five years (Master's) or Three years (PhD) of industry experience in downstream process development for large biomolecules, including mRNA or pDNA.
Hands‑on experience with purification techniques such as affinity capture, ion exchange, and hydrophobic interactions.
Three years of experience supporting CMC activities, including process and analytical development.
Preferred Qualifications
PhD in Molecular Biology, Biotechnology, Bioengineering, Chemical Engineering, or a related field.
Experience with Quality by Design principles and DOE studies for process optimization.
Knowledge of regulatory guidelines (FDA/ICH/ISPE) for process validation and technology transfer.
Familiarity with nucleic acid analytical technologies.
Strong problem‑solving skills and ability to work collaboratively in a matrixed environment.
Compensation If you are based in Cambridge, MA; Waltham, MA; Rockville, MD; or San Francisco, CA, the annual base salary for new hires in this position ranges from $113,025 to $188,375. This range reflects factors such as location, skills, experience, education, and market rate. In addition, the position offers an annual bonus and eligibility to participate in our share‑based long‑term incentive program. Available benefits include health care and other insurance benefits (for employees and families), retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave.
Benefits Summary Please visit
GSK US Benefits Summary
to learn more about the comprehensive benefits program GSK offers US employees.
Why GSK? Uniting science, technology, and talent to get ahead of disease together. GSK is a global biopharma company with a purpose to unite science, technology, and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases – to impact health at scale.
People and patients around the world count on the medicines and vaccines we make, so we’re committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.
Equal Opportunity Statement GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.
Additional Information Our recruitment team may contact you for adjustments or further assistance. If your inquiry does not relate to adjustments, we will not be able to support you through these channels. You can find answers to many common questions in our Recruitment FAQ guide.
For more information, visit the Centers for Medicare & Medicaid Services website at https://openpaymentsdata.cms.gov/.
#J-18808-Ljbffr