Takeda
Associate Director, High-Throughput Mass Spectrometry
Takeda, Boston, Massachusetts, us, 02298
Associate Director, High-Throughput Mass Spectrometry
Join to apply for the
Associate Director, High-Throughput Mass Spectrometry
role at
Takeda .
This role is part of Takeda’s forward‑looking, world‑class R&D organization that unlocks innovation and delivers transformative therapies to patients.
Objective / Purpose:
We are building the “lab of the future” to power faster, smarter decision‑making across our discovery and development portfolio. As an Associate Director of High‑Throughput Mass Spectrometry (Acoustic MS) within the Lead Profiling / DMTA team, you will be a key technical and strategic contributor enabling high‑throughput, high‑quality data generation for DMTA cycles.
Responsibilities include:
High‑Throughput Mass Spectrometry & Acoustic MS:
Lead the design, development, and optimization of high‑throughput MS workflows, focusing on acoustic MS platforms for small‑molecule and biotherapeutic lead profiling. Own the end‑to‑end lifecycle of acoustic MS methods from feasibility and method development through validation, troubleshooting, and routine deployment. Drive continuous performance improvements in sensitivity, robustness, throughput, and cost‑per‑sample.
DMTA Lead Profiling & ADME Support:
Execute and oversee DMTA lead profiling assays, ensuring reliable, timely delivery of high‑quality MS data for project teams. Adapt and translate ADME assays to high‑throughput MS formats, leveraging miniaturization and automation. Partner with DMPK, medicinal chemistry, biology, and data science to align assay design and data outputs with discovery programs.
Lab Automation & Lab of the Future:
Collaborate closely with the Lab Automation and Transformation organization to integrate MS platforms into end‑to‑end automated workflows. Provide scientific and technical input into the design and selection of new instruments, automation hardware, and software. Contribute to digitalization efforts defining data standards and connectivity between instruments, LIMS/ELNs, and analytics platforms.
Operational Excellence & Quality:
Establish and maintain robust QC procedures, SOPs, and best practices for high‑throughput MS operations. Drive root‑cause investigations and implement corrective actions when assay performance drifts or system issues arise. Ensure data integrity, reproducibility, and compliance with Takeda quality and safety standards.
Collaboration, Influence & Leadership:
Act as the subject‑matter expert for high‑throughput and acoustic MS within the lead profiling and automation communities. Provide training, mentorship, and technical guidance to scientists and associates. Communicate clearly with interdisciplinary stakeholders, presenting complex technical topics in an accessible way.
Education & Experience:
Expected Ph.D. in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or related field, 6+ years of relevant industry/postdoctoral experience; OR M.S. with 12 years of experience; OR B.S. with 14 years of experience.
Deep hands‑on expertise in mass spectrometry, with a track record of developing and running high‑throughput MS assays.
Hands‑on experience with acoustic MS platforms (method development, optimization, troubleshooting, routine operation).
Experience in quantitative bioanalytical methods for small molecules and/or biotherapeutics.
Proven experience with DMTA or screening workflows, preferably in lead profiling or DMPK/ADME support.
Proficiency with MS data analysis tools and scripting (Python, R, Spotfire) is a plus.
Adaptation of ADME assays to acoustic MS and miniaturized plate‑based workflows.
Integration of MS instruments with automated sample preparation and plate handling systems.
Experience with high‑throughput environments, design‑of‑experiment approaches, and LIMS/ELN integration.
Background in drug discovery lead optimization and understanding of how ADME and profiling data inform SAR and project decisions.
Base pay range:
$153,600 – $241,340 per year. Additional compensation may be awarded based on qualifications and company incentive plans.
Location:
Cambridge, MA (hybrid work).
Takeda Compensation and Benefits Summary:
Standard U.S. benefits including medical, dental, vision, 401(k), short‑term and long‑term disability, life insurance, tuition reimbursement, paid volunteer time, company holidays, well‑being benefits, sick time, and paid vacation.
EEO Statement:
Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.
It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment.
#J-18808-Ljbffr
Associate Director, High-Throughput Mass Spectrometry
role at
Takeda .
This role is part of Takeda’s forward‑looking, world‑class R&D organization that unlocks innovation and delivers transformative therapies to patients.
Objective / Purpose:
We are building the “lab of the future” to power faster, smarter decision‑making across our discovery and development portfolio. As an Associate Director of High‑Throughput Mass Spectrometry (Acoustic MS) within the Lead Profiling / DMTA team, you will be a key technical and strategic contributor enabling high‑throughput, high‑quality data generation for DMTA cycles.
Responsibilities include:
High‑Throughput Mass Spectrometry & Acoustic MS:
Lead the design, development, and optimization of high‑throughput MS workflows, focusing on acoustic MS platforms for small‑molecule and biotherapeutic lead profiling. Own the end‑to‑end lifecycle of acoustic MS methods from feasibility and method development through validation, troubleshooting, and routine deployment. Drive continuous performance improvements in sensitivity, robustness, throughput, and cost‑per‑sample.
DMTA Lead Profiling & ADME Support:
Execute and oversee DMTA lead profiling assays, ensuring reliable, timely delivery of high‑quality MS data for project teams. Adapt and translate ADME assays to high‑throughput MS formats, leveraging miniaturization and automation. Partner with DMPK, medicinal chemistry, biology, and data science to align assay design and data outputs with discovery programs.
Lab Automation & Lab of the Future:
Collaborate closely with the Lab Automation and Transformation organization to integrate MS platforms into end‑to‑end automated workflows. Provide scientific and technical input into the design and selection of new instruments, automation hardware, and software. Contribute to digitalization efforts defining data standards and connectivity between instruments, LIMS/ELNs, and analytics platforms.
Operational Excellence & Quality:
Establish and maintain robust QC procedures, SOPs, and best practices for high‑throughput MS operations. Drive root‑cause investigations and implement corrective actions when assay performance drifts or system issues arise. Ensure data integrity, reproducibility, and compliance with Takeda quality and safety standards.
Collaboration, Influence & Leadership:
Act as the subject‑matter expert for high‑throughput and acoustic MS within the lead profiling and automation communities. Provide training, mentorship, and technical guidance to scientists and associates. Communicate clearly with interdisciplinary stakeholders, presenting complex technical topics in an accessible way.
Education & Experience:
Expected Ph.D. in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or related field, 6+ years of relevant industry/postdoctoral experience; OR M.S. with 12 years of experience; OR B.S. with 14 years of experience.
Deep hands‑on expertise in mass spectrometry, with a track record of developing and running high‑throughput MS assays.
Hands‑on experience with acoustic MS platforms (method development, optimization, troubleshooting, routine operation).
Experience in quantitative bioanalytical methods for small molecules and/or biotherapeutics.
Proven experience with DMTA or screening workflows, preferably in lead profiling or DMPK/ADME support.
Proficiency with MS data analysis tools and scripting (Python, R, Spotfire) is a plus.
Adaptation of ADME assays to acoustic MS and miniaturized plate‑based workflows.
Integration of MS instruments with automated sample preparation and plate handling systems.
Experience with high‑throughput environments, design‑of‑experiment approaches, and LIMS/ELN integration.
Background in drug discovery lead optimization and understanding of how ADME and profiling data inform SAR and project decisions.
Base pay range:
$153,600 – $241,340 per year. Additional compensation may be awarded based on qualifications and company incentive plans.
Location:
Cambridge, MA (hybrid work).
Takeda Compensation and Benefits Summary:
Standard U.S. benefits including medical, dental, vision, 401(k), short‑term and long‑term disability, life insurance, tuition reimbursement, paid volunteer time, company holidays, well‑being benefits, sick time, and paid vacation.
EEO Statement:
Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.
It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment.
#J-18808-Ljbffr