PineTree Therapeutics Inc
Principal Scientist, In Vivo Pharmacology
PineTree Therapeutics Inc, Cambridge, Massachusetts, us, 02140
Join to apply for the
Principal Scientist, In Vivo Pharmacology
role at
PineTree Therapeutics Inc Join to apply for the
Principal Scientist, In Vivo Pharmacology
role at
PineTree Therapeutics Inc (Full-Time, On-Site)
Location:
PineTree Therapeutics, Cambridge, MA
Job Type:
Full-Time, on-site
Start Date:
Immediate
Department:
Translational Research
Reports to:
Executive Director, Translational Research
PineTreeTherapeutics is seeking aseasoned invivo pharmacologist / vivarium lead to own all rodent efficacy, PK/PD and exploratory toxicology studies that drive our multispecific antibody‑degrader pipeline. You will direct day‑to‑day vivarium operations, author and steward IACUC protocols, and ensure every study is executed to the highest scientific and regulatory standards. While a working knowledge of cell‑based and molecular techniques is valuable, success in this role hinges on exceptional invivo expertise, study design acumen, and organizational leadership.
Key
Responsibilities
In
Vivo Pharmacology & Study Management
Translate project hypotheses into robust animal studies (xenograft, syngeneic, GEMM, PDX, PK/PD, dose‑range finder). Lead or supervise all dosing routes (IP,IV,PO,SC), tumor measurements, and collection of blood/tissue for downstream analyses. Perform power calculations, analyze data in Prism/Spotfire, and present findings to cross‑functional teams and in regulatory documents.
Vivarium Operations & Compliance
Oversee internal vivarium logistics. Serve as Study Director and primary contact for all IACUC activities—draft, amend, and maintain protocols, train staff in animal welfare regulations and SOPs. Champion a culture of safety, humane care, and continuous improvement.
Team Leadership & External Interfaces
Mentor invivo scientists and research associates; provide hands‑on training in rodent techniques and study execution. Manage CRO relationships for overflow or specialized studies; draft/review SOWs, budgets, timelines, and data packages. Partner with DMPK/Tox, CMC, and Regulatory colleagues on IND‑enabling toxicology and bioanalytical plans.
Translational Support
Advise on, or occasionally perform, cell culture, flow cytometry, IHC, PCR, or CRISPR activities that directly inform invivo study interpretation or help with new model establishment. Integrate mechanistic readouts (e.g., IHC, RNA‑seq) to enhance translational relevance of animal data.
RequiredQualifications
Ph.D. in Pharmacology, Cancer Biology, or related field with 8+years of industry experience executing and managing preclinical invivo studies (or M.S. with 12+years). Demonstrated mastery of rodent handling, complex dosing techniques, PK/PD sampling, and tumor efficacy models. Deep working knowledge of IACUC, USDA, OLAW, and AAALAC regulations; proven record of authoring and maintaining animal protocols. Experience leading vivarium operations or serving as Study Director across multiple concurrent studies. Strong data analysis skills and fluency with statistical approaches for invivo datasets. Excellent communication skills with a track record of contributing to IND filings. Proven ability to lead and mentor multidisciplinary teams.
PreferredSkills & Experience
Background in multispecific antibodies, ADCs, targeted protein degraders, or oncology biologics. Prior oversight of IND‑enabling PK and toxicology packages and CRO management. Familiarity with imaging modalities (IVIS, μCT) and advanced translational assays (CyTOF, spatial transcriptomics). Working knowledge of invitro molecular biology or cell‑engineering methods that facilitate study interpretation and new model development. Demonstrated success advancing programs from target validation through candidate nomination.
Physical Requirements
Prolonged periods of sitting at a desk and working on a computer. Prolonged periods of standing and bending. Must be able to lift up to 20 pounds at times. An individual in this position may be exposed to bloodborne pathogens, physical hazards (e.g., needle pricks, etc.), and chemical hazards.
What We Offer
Opportunity to drive first‑in‑class antibody degrader therapeutics toward the clinic. Collaborative start‑up environment with direct visibility to executive leadership. Competitive compensation package, equity participation, and comprehensive benefits. Competitive salary and bonus program. Comprehensive benefits including health, dental, and vision insurance 401(k) plan with company matching. Opportunities for professional growth and development in a dynamic biotech environment.
Pinetree is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. Pinetree will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
Recruitment & Staffing Agencies: Pinetree does not accept unsolicited resumes from any source other than candidates. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Pinetree, and Pinetree will not owe any referral or other fees with respect thereto.
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Email *
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Upload Resume *
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Principal Scientist, In Vivo Pharmacology
role at
PineTree Therapeutics Inc Join to apply for the
Principal Scientist, In Vivo Pharmacology
role at
PineTree Therapeutics Inc (Full-Time, On-Site)
Location:
PineTree Therapeutics, Cambridge, MA
Job Type:
Full-Time, on-site
Start Date:
Immediate
Department:
Translational Research
Reports to:
Executive Director, Translational Research
PineTreeTherapeutics is seeking aseasoned invivo pharmacologist / vivarium lead to own all rodent efficacy, PK/PD and exploratory toxicology studies that drive our multispecific antibody‑degrader pipeline. You will direct day‑to‑day vivarium operations, author and steward IACUC protocols, and ensure every study is executed to the highest scientific and regulatory standards. While a working knowledge of cell‑based and molecular techniques is valuable, success in this role hinges on exceptional invivo expertise, study design acumen, and organizational leadership.
Key
Responsibilities
In
Vivo Pharmacology & Study Management
Translate project hypotheses into robust animal studies (xenograft, syngeneic, GEMM, PDX, PK/PD, dose‑range finder). Lead or supervise all dosing routes (IP,IV,PO,SC), tumor measurements, and collection of blood/tissue for downstream analyses. Perform power calculations, analyze data in Prism/Spotfire, and present findings to cross‑functional teams and in regulatory documents.
Vivarium Operations & Compliance
Oversee internal vivarium logistics. Serve as Study Director and primary contact for all IACUC activities—draft, amend, and maintain protocols, train staff in animal welfare regulations and SOPs. Champion a culture of safety, humane care, and continuous improvement.
Team Leadership & External Interfaces
Mentor invivo scientists and research associates; provide hands‑on training in rodent techniques and study execution. Manage CRO relationships for overflow or specialized studies; draft/review SOWs, budgets, timelines, and data packages. Partner with DMPK/Tox, CMC, and Regulatory colleagues on IND‑enabling toxicology and bioanalytical plans.
Translational Support
Advise on, or occasionally perform, cell culture, flow cytometry, IHC, PCR, or CRISPR activities that directly inform invivo study interpretation or help with new model establishment. Integrate mechanistic readouts (e.g., IHC, RNA‑seq) to enhance translational relevance of animal data.
RequiredQualifications
Ph.D. in Pharmacology, Cancer Biology, or related field with 8+years of industry experience executing and managing preclinical invivo studies (or M.S. with 12+years). Demonstrated mastery of rodent handling, complex dosing techniques, PK/PD sampling, and tumor efficacy models. Deep working knowledge of IACUC, USDA, OLAW, and AAALAC regulations; proven record of authoring and maintaining animal protocols. Experience leading vivarium operations or serving as Study Director across multiple concurrent studies. Strong data analysis skills and fluency with statistical approaches for invivo datasets. Excellent communication skills with a track record of contributing to IND filings. Proven ability to lead and mentor multidisciplinary teams.
PreferredSkills & Experience
Background in multispecific antibodies, ADCs, targeted protein degraders, or oncology biologics. Prior oversight of IND‑enabling PK and toxicology packages and CRO management. Familiarity with imaging modalities (IVIS, μCT) and advanced translational assays (CyTOF, spatial transcriptomics). Working knowledge of invitro molecular biology or cell‑engineering methods that facilitate study interpretation and new model development. Demonstrated success advancing programs from target validation through candidate nomination.
Physical Requirements
Prolonged periods of sitting at a desk and working on a computer. Prolonged periods of standing and bending. Must be able to lift up to 20 pounds at times. An individual in this position may be exposed to bloodborne pathogens, physical hazards (e.g., needle pricks, etc.), and chemical hazards.
What We Offer
Opportunity to drive first‑in‑class antibody degrader therapeutics toward the clinic. Collaborative start‑up environment with direct visibility to executive leadership. Competitive compensation package, equity participation, and comprehensive benefits. Competitive salary and bonus program. Comprehensive benefits including health, dental, and vision insurance 401(k) plan with company matching. Opportunities for professional growth and development in a dynamic biotech environment.
Pinetree is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. Pinetree will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
Recruitment & Staffing Agencies: Pinetree does not accept unsolicited resumes from any source other than candidates. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Pinetree, and Pinetree will not owe any referral or other fees with respect thereto.
Career Inquiry Form
Indicates required field
FIRST NAME *
LAST NAME *
Email *
Phone *
Upload Resume *
Max file size: 250MB
Type or Paste Cover Letter *
Submit Seniority level
Seniority level Mid-Senior level Employment type
Employment type Full-time Job function
Job function Research, Analyst, and Information Technology Industries Biotechnology Referrals increase your chances of interviewing at PineTree Therapeutics Inc by 2x Get notified about new Principal Scientist jobs in
Cambridge, MA . Woburn, MA $130,000.00-$190,000.00 1 week ago Senior Research Scientist - Energy Systems and Business Analysis
Cambridge, MA $180,000.00-$270,000.00 6 days ago Cambridge, MA $156,000.00-$296,500.00 2 weeks ago Principal Scientist , Analytical Science Lead
Waltham, MA $160,000.00-$190,000.00 2 weeks ago Principal Scientist, Computational Chemistry
Scientist/Senior Scientist, Chemical Development and Manufacturing
Sr./Principal Scientist, Computational Chemistry
Cambridge, MA $145,000.00-$200,000.00 1 week ago Senior Scientist, Drug Substance Development and Manufacturing
Greater Boston $115,000.00-$140,000.00 2 weeks ago Computational Chemistry Senior Research Scientist
Boston, MA $123,400.00-$185,100.00 2 days ago Director / Scientist of Antibody Research and Development
Senior Principal Scientist, Development DMPK
Senior Principal Research Scientist, Analytical Chemistry
Cambridge, MA $156,000.00-$296,500.00 2 weeks ago Principal Research Scientist II, Analytical Development (Onsite-Waltham, MA)
Waltham, MA $137,500.00-$261,000.00 3 days ago Senior Scientist Translational Gene editing Development with AAV, Gene and Cell Therapeutics Platform Research Organization
Senior Scientist, Pharmaceutical Development CMC (CONTRACT)
Senior Scientist, Analytical Development
Senior Principal Research Scientist, Physics-Based Methods Development
Ophthalmology Senior Scientist, Translational Development
Senior Quantum Scientist — Quantum Algorithms
Process Development Senior Scientist – Synthetics Analytical Chemistry
Senior Scientist, Analytical Development (Chemistry), US
Cambridge, MA $122,250.00-$176,583.33 1 week ago We’re unlocking community knowledge in a new way. Experts add insights directly into each article, started with the help of AI.
#J-18808-Ljbffr