Jnana Therapeutics
Director, Translational Medicine & Biomarker Science, Immunology
Jnana Therapeutics, Boston, Massachusetts, us, 02298
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Director, Translational Medicine & Biomarker Science, Immunology
role at
Jnana Therapeutics
Jnana Therapeutics, a wholly owned subsidiary of Otsuka Pharmaceutical, is a clinical-stage biotechnology company leveraging its next-generation RAPID chemoproteomics platform to discover medicines for highly validated, challenging-to-drug targets to treat diseases with high unmet needs. Jnana is focused on developing first‑ and best‑in‑class oral therapies to treat a wide range of diseases, including rare diseases and immune‑mediated diseases, with a particular emphasis on innovative immunology programs.
About The Opportunity We are seeking a Director‑level scientist with deep expertise in translational research, immunology, and biomarker strategy, and a strong background in early clinical development. This Boston‑based role is embedded within Jnana’s discovery team and focuses on supporting our discovery‑stage immunology programs by integrating clinical and human biology insights into actionable preclinical and translational strategy.
Responsibilities
Lead clinical translational and biomarker strategy for late discovery‑stage programs, primarily in immunology.
Design and implement biomarker plans that enable early decision‑making, patient stratification, and first‑in‑human (FIH) study design.
Provide clinical and translational insight into preclinical data, helping teams define and validate mechanistic hypotheses.
Collaborate closely with discovery biology, pharmacology, and nonclinical safety teams to evaluate new targets and shape development paths.
Act as a strategic interface with Early Development colleagues, contributing to early clinical planning and ensuring effective implementation of translational insights.
Stay at the forefront of biomarker innovation by leading or contributing to scientific collaborations, academic partnerships, and internal strategic forums.
Desired Qualifications & Past Experience
MD, PhD, PharmD, or equivalent advanced degree with training in immunology, clinical pathology or related field; board certification in rheumatology or other immunology‑relevant discipline is a plus.
At least 2+ years of industry experience in translational medicine and early clinical development, with strong working knowledge of drug discovery, biomarker, and translational tools. Experience in a biotech or early‑stage setting strongly preferred.
Proven ability to design, lead, and implement biomarker strategy in First‑in‑Human through Proof of Concept trials.
Strong conceptual understanding of immunologic mechanisms and translational models.
Demonstrated ability to connect mechanistic biology with practical clinical endpoints and trial design considerations.
Experience leading teams, mentoring scientific staff and working effectively in cross‑functional environments.
Excellent communication skills with the ability to influence across functions and levels.
Experience with small molecules and/or human cell‑based translational platforms is a plus.
Minimum $188,569.00 – Maximum $271,068.80, plus incentive opportunity. This range represents typical pay for the role and may be positioned within or above this range based on experience and matching internal incumbents.
Application Deadline This posting will remain open for a minimum of 5 business days.
Benefits
Comprehensive medical, dental, vision, and prescription drug coverage.
Basic life, accidental death & dismemberment, short‑term and long‑term disability insurance.
Tuition reimbursement and student loan assistance.
Generous 401(k) match.
Flexible time off, paid holidays, and paid leave programs.
Equal Opportunity Employer Jnana Therapeutics is an equal opportunity employer. All qualified applicants are encouraged to apply and will be given consideration for employment without regard to race, color, sex, gender identity or gender expression, sexual orientation, age, disability, religion, national origin, veteran status, marital status, or any other legally protected characteristic.
Disability Accommodations If you are a qualified individual with a disability or a disabled veteran, you may request a reasonable accommodation if you are unable or limited in your ability to apply to this job opening as a result of your disability. You may request accommodations by contacting Accommodation Request.
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Director, Translational Medicine & Biomarker Science, Immunology
role at
Jnana Therapeutics
Jnana Therapeutics, a wholly owned subsidiary of Otsuka Pharmaceutical, is a clinical-stage biotechnology company leveraging its next-generation RAPID chemoproteomics platform to discover medicines for highly validated, challenging-to-drug targets to treat diseases with high unmet needs. Jnana is focused on developing first‑ and best‑in‑class oral therapies to treat a wide range of diseases, including rare diseases and immune‑mediated diseases, with a particular emphasis on innovative immunology programs.
About The Opportunity We are seeking a Director‑level scientist with deep expertise in translational research, immunology, and biomarker strategy, and a strong background in early clinical development. This Boston‑based role is embedded within Jnana’s discovery team and focuses on supporting our discovery‑stage immunology programs by integrating clinical and human biology insights into actionable preclinical and translational strategy.
Responsibilities
Lead clinical translational and biomarker strategy for late discovery‑stage programs, primarily in immunology.
Design and implement biomarker plans that enable early decision‑making, patient stratification, and first‑in‑human (FIH) study design.
Provide clinical and translational insight into preclinical data, helping teams define and validate mechanistic hypotheses.
Collaborate closely with discovery biology, pharmacology, and nonclinical safety teams to evaluate new targets and shape development paths.
Act as a strategic interface with Early Development colleagues, contributing to early clinical planning and ensuring effective implementation of translational insights.
Stay at the forefront of biomarker innovation by leading or contributing to scientific collaborations, academic partnerships, and internal strategic forums.
Desired Qualifications & Past Experience
MD, PhD, PharmD, or equivalent advanced degree with training in immunology, clinical pathology or related field; board certification in rheumatology or other immunology‑relevant discipline is a plus.
At least 2+ years of industry experience in translational medicine and early clinical development, with strong working knowledge of drug discovery, biomarker, and translational tools. Experience in a biotech or early‑stage setting strongly preferred.
Proven ability to design, lead, and implement biomarker strategy in First‑in‑Human through Proof of Concept trials.
Strong conceptual understanding of immunologic mechanisms and translational models.
Demonstrated ability to connect mechanistic biology with practical clinical endpoints and trial design considerations.
Experience leading teams, mentoring scientific staff and working effectively in cross‑functional environments.
Excellent communication skills with the ability to influence across functions and levels.
Experience with small molecules and/or human cell‑based translational platforms is a plus.
Minimum $188,569.00 – Maximum $271,068.80, plus incentive opportunity. This range represents typical pay for the role and may be positioned within or above this range based on experience and matching internal incumbents.
Application Deadline This posting will remain open for a minimum of 5 business days.
Benefits
Comprehensive medical, dental, vision, and prescription drug coverage.
Basic life, accidental death & dismemberment, short‑term and long‑term disability insurance.
Tuition reimbursement and student loan assistance.
Generous 401(k) match.
Flexible time off, paid holidays, and paid leave programs.
Equal Opportunity Employer Jnana Therapeutics is an equal opportunity employer. All qualified applicants are encouraged to apply and will be given consideration for employment without regard to race, color, sex, gender identity or gender expression, sexual orientation, age, disability, religion, national origin, veteran status, marital status, or any other legally protected characteristic.
Disability Accommodations If you are a qualified individual with a disability or a disabled veteran, you may request a reasonable accommodation if you are unable or limited in your ability to apply to this job opening as a result of your disability. You may request accommodations by contacting Accommodation Request.
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