Gilead Sciences
Job Description
Gilead Sciences, Inc. is a research‑based biopharmaceutical company founded in 1987. Together we deliver life‑saving therapies to patients worldwide. We are looking for a Scientist to contribute to the research and development of biologics targeting unmet medical needs through biochemical characterization and novel method development supporting clinical and commercial programs. The successful candidate will possess a detailed understanding of proteins and carbohydrates and will be highly motivated to excel in analytical chemistry, biochemistry, biological mass spectrometry, high‑performance or ultra‑performance liquid chromatography, electrophoretic separations, enzymology, statistics, chemical and biophysical structural elucidation, and bioinformatics.
Key Responsibilities
Support late‑stage assay development by performing mass spectrometry to characterize molecules, degradation pathways, and define critical quality attributes in a phase‑appropriate context.
Contribute to analytical method development and qualification for protein characterization activities.
Support comparability and stability studies using mass spectrometry.
Operate, maintain, and troubleshoot Waters, Sciex, Agilent, Bruker QTOFs, and Thermo Orbitrap mass spectrometers.
Collaborate with team members to develop advanced techniques for substance, assay, and tool characterization.
Represent the Structure Characterization group in cross‑functional project teams.
Participate in technology transfer of assays from analytical development to QC and external CRO/CMOs.
Coordinate analysis of in‑process and product‑related impurities for process comparability studies.
Conduct scientific research to support drug candidate development and marketed drug research.
Advise project teams on experiment planning and execution, considering economic, regulatory, and safety factors.
Present experimental results, interpret data, and draw conclusions.
Stay current with scientific literature and apply relevant knowledge to projects.
Represent the company at national and international conferences.
Basic Qualifications
BS degree with at least six (6) years of industry experience OR MS degree with at least four (4) years of industry experience.
Strong knowledge of mass spectrometry, experimental design, and assay development.
Excellent verbal, technical writing, and interpersonal communication skills.
Ability to work independently and collaboratively in a matrixed environment.
Strong organizational and planning skills.
Proficient in Microsoft Office applications.
Preferred Qualifications
PhD in Chemistry or a related discipline with limited industry experience.
Familiarity with techniques such as:
Peptide mapping by LC‑MS/MS
Intact mass analysis
MS/MS for protein and carbohydrate structural elucidation/quantification
Kinetic analyses
Ultra‑performance chromatography
Proteolytic/chemical processing
Knowledge of ICH guidelines and GMP.
Expertise in mass spectrometry analysis software (Protein Metrics, Thermo BioPharma Finder, Skyline).
Experience with data analysis and visualization tools (Python, R, JMP, Spotfire).
Demonstrated ability to mentor junior team members and lead cross‑functional environments.
Salary The salary range for this position is $146,540.00 – $189,640.00. Gilead considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. Compensation may also include discretionary annual bonus, inventory‑based long‑term incentives, paid time off, and a benefits package.
Benefits Eligible employees may participate in benefit plans, subject to the terms and conditions of the applicable plans. Benefits include company‑sponsored medical, dental, vision, and life insurance plans.
For additional benefits information, visit https://www.gilead.com/careers/compensation-benefits-and-wellbeing
Equal Employment Opportunity Gilead Sciences Inc. is committed to providing equal employment opportunities to all employees and applicants for employment, and is dedicated to fostering an inclusive work environment comprised of diverse perspectives, backgrounds, and experiences. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, sex, age, sexual orientation, physical or mental disability, genetic information, gender identity or expression, veteran status, or other non‑job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans’ Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact ApplicantAccommodations@gilead.com for assistance.
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Key Responsibilities
Support late‑stage assay development by performing mass spectrometry to characterize molecules, degradation pathways, and define critical quality attributes in a phase‑appropriate context.
Contribute to analytical method development and qualification for protein characterization activities.
Support comparability and stability studies using mass spectrometry.
Operate, maintain, and troubleshoot Waters, Sciex, Agilent, Bruker QTOFs, and Thermo Orbitrap mass spectrometers.
Collaborate with team members to develop advanced techniques for substance, assay, and tool characterization.
Represent the Structure Characterization group in cross‑functional project teams.
Participate in technology transfer of assays from analytical development to QC and external CRO/CMOs.
Coordinate analysis of in‑process and product‑related impurities for process comparability studies.
Conduct scientific research to support drug candidate development and marketed drug research.
Advise project teams on experiment planning and execution, considering economic, regulatory, and safety factors.
Present experimental results, interpret data, and draw conclusions.
Stay current with scientific literature and apply relevant knowledge to projects.
Represent the company at national and international conferences.
Basic Qualifications
BS degree with at least six (6) years of industry experience OR MS degree with at least four (4) years of industry experience.
Strong knowledge of mass spectrometry, experimental design, and assay development.
Excellent verbal, technical writing, and interpersonal communication skills.
Ability to work independently and collaboratively in a matrixed environment.
Strong organizational and planning skills.
Proficient in Microsoft Office applications.
Preferred Qualifications
PhD in Chemistry or a related discipline with limited industry experience.
Familiarity with techniques such as:
Peptide mapping by LC‑MS/MS
Intact mass analysis
MS/MS for protein and carbohydrate structural elucidation/quantification
Kinetic analyses
Ultra‑performance chromatography
Proteolytic/chemical processing
Knowledge of ICH guidelines and GMP.
Expertise in mass spectrometry analysis software (Protein Metrics, Thermo BioPharma Finder, Skyline).
Experience with data analysis and visualization tools (Python, R, JMP, Spotfire).
Demonstrated ability to mentor junior team members and lead cross‑functional environments.
Salary The salary range for this position is $146,540.00 – $189,640.00. Gilead considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. Compensation may also include discretionary annual bonus, inventory‑based long‑term incentives, paid time off, and a benefits package.
Benefits Eligible employees may participate in benefit plans, subject to the terms and conditions of the applicable plans. Benefits include company‑sponsored medical, dental, vision, and life insurance plans.
For additional benefits information, visit https://www.gilead.com/careers/compensation-benefits-and-wellbeing
Equal Employment Opportunity Gilead Sciences Inc. is committed to providing equal employment opportunities to all employees and applicants for employment, and is dedicated to fostering an inclusive work environment comprised of diverse perspectives, backgrounds, and experiences. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, sex, age, sexual orientation, physical or mental disability, genetic information, gender identity or expression, veteran status, or other non‑job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans’ Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact ApplicantAccommodations@gilead.com for assistance.
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