BioSpace
Senior Scientist - Targeted Protein Degradation
BioSpace, Thousand Oaks, California, United States, 91362
Senior Scientist – Targeted Protein Degradation
Amgen’s Induced Proximity Platform (IPP) is dedicated to pioneering drug modalities that harness proximity biology. We are seeking a Senior Scientist to play a central role in the discovery and development of molecular glue degraders for high‑value targets.
Key Responsibilities
Design, establish, and implement phenotypic‑based screening platforms to enable the discovery of novel induced proximity mechanisms.
Develop and optimize assays that capture cellular context, functional outcomes, and disease relevance.
Work with automation and high‑throughput screening teams to scale phenotypic platforms across IPP.
Integrate advanced imaging, omics, and data‑science approaches to extract actionable biological insights from phenotypic screens.
Apply biochemical, biophysical, and cell‑biology techniques to understand degrader mechanisms of action.
Partner with cross‑functional teams within IPP and external collaborators to broaden the scope of induced proximity drug discovery.
Share insights through internal presentations, publications, and external conferences.
Provide scientific mentorship to junior scientists and contribute to a culture of curiosity and innovation.
Basic Qualifications
Doctorate (PhD, PharmD, or MD) OR relevant post‑doc.
OR Master’s degree and 3 years of directly related experience.
OR Bachelor’s degree and 5 years of directly related experience.
Preferred Qualifications
PhD in Chemical Biology, Cell Biology, Biochemistry, Pharmacology, or related field, with post‑doctoral training or equivalent industry experience.
2+ years of relevant industry experience in biotechnology or pharmaceutical research.
Demonstrated expertise in targeted protein degradation, molecular glue biology, or proximity‑based drug discovery.
Hands‑on experience developing and executing cellular assays or phenotypic screening approaches.
Track record of assay development for high‑content or high‑throughput phenotypic screening, including use of automation and advanced imaging technologies.
Proficiency in cellular and molecular biology techniques such as CRISPR‑based perturbations, proteomics, or transcriptomics applied to phenotypic readouts.
Experience applying systems biology and data integration approaches to interpret complex phenotypic datasets.
Strong scientific creativity with a record of publications, patents, or conference presentations in relevant fields.
Excellent interpersonal and communication skills; ability to work collaboratively in a matrixed research environment.
What You Can Expect From Us
A comprehensive employee benefits package, including health, dental, vision, life and disability insurance, and flexible spending accounts.
A retirement and savings plan with generous company contributions.
A discretionary annual bonus program.
Stock‑based long‑term incentives.
Award‑winning time‑off plans.
Flexible work models, including remote and hybrid arrangements where possible.
Amgen is an Equal Opportunity Employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will provide reasonable accommodation for individuals with disabilities.
#J-18808-Ljbffr
Key Responsibilities
Design, establish, and implement phenotypic‑based screening platforms to enable the discovery of novel induced proximity mechanisms.
Develop and optimize assays that capture cellular context, functional outcomes, and disease relevance.
Work with automation and high‑throughput screening teams to scale phenotypic platforms across IPP.
Integrate advanced imaging, omics, and data‑science approaches to extract actionable biological insights from phenotypic screens.
Apply biochemical, biophysical, and cell‑biology techniques to understand degrader mechanisms of action.
Partner with cross‑functional teams within IPP and external collaborators to broaden the scope of induced proximity drug discovery.
Share insights through internal presentations, publications, and external conferences.
Provide scientific mentorship to junior scientists and contribute to a culture of curiosity and innovation.
Basic Qualifications
Doctorate (PhD, PharmD, or MD) OR relevant post‑doc.
OR Master’s degree and 3 years of directly related experience.
OR Bachelor’s degree and 5 years of directly related experience.
Preferred Qualifications
PhD in Chemical Biology, Cell Biology, Biochemistry, Pharmacology, or related field, with post‑doctoral training or equivalent industry experience.
2+ years of relevant industry experience in biotechnology or pharmaceutical research.
Demonstrated expertise in targeted protein degradation, molecular glue biology, or proximity‑based drug discovery.
Hands‑on experience developing and executing cellular assays or phenotypic screening approaches.
Track record of assay development for high‑content or high‑throughput phenotypic screening, including use of automation and advanced imaging technologies.
Proficiency in cellular and molecular biology techniques such as CRISPR‑based perturbations, proteomics, or transcriptomics applied to phenotypic readouts.
Experience applying systems biology and data integration approaches to interpret complex phenotypic datasets.
Strong scientific creativity with a record of publications, patents, or conference presentations in relevant fields.
Excellent interpersonal and communication skills; ability to work collaboratively in a matrixed research environment.
What You Can Expect From Us
A comprehensive employee benefits package, including health, dental, vision, life and disability insurance, and flexible spending accounts.
A retirement and savings plan with generous company contributions.
A discretionary annual bonus program.
Stock‑based long‑term incentives.
Award‑winning time‑off plans.
Flexible work models, including remote and hybrid arrangements where possible.
Amgen is an Equal Opportunity Employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will provide reasonable accommodation for individuals with disabilities.
#J-18808-Ljbffr