BioSpace
Principal Scientist/Sr. Principal Scientist, Protein Downstream Purification
BioSpace, Indianapolis, Indiana, us, 46262
Principal Scientist/Sr. Principal Scientist, Protein Downstream Purification
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global health‑care leader headquartered in Indianapolis, Indiana. Our employees worldwide work to discover and bring life‑changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first.
Overview At Lilly, we serve an extraordinary purpose. We make a difference for people around the globe by discovering, developing and delivering medicines that help them live longer, healthier, more active lives. Not only do we deliver breakthrough medications, but we also develop creative solutions to support communities through philanthropy and volunteerism.
Position Summary The Bioproduct Research and Development (BR&D) organization strives to deliver innovative medicines to patients through development and commercialization of monoclonal antibodies, novel therapeutic proteins, peptides, bioconjugates, cell therapies, gene therapies and other genetic medicines. This multidisciplinary group works collaboratively with discovery, manufacturing, quality and business units. The Principal Scientist/Senior Principal Scientist is responsible for downstream purification development activities related to the production of bioproduct active pharmaceutical ingredients—including purification process definition and optimization, process robustness studies, process transfers to pilot plant and manufacturing sites, and authorship of downstream process development sections of regulatory submissions. The position will interact closely with other scientists in BR&D as well as Discovery, Technical Services for Manufacturing, and Manufacturing scientists, and will be an integral participant on multidisciplinary CMC project teams that support bioproduct process and product development activities.
Responsibilities
Design and execute appropriate purification development experiments for generation of bioproduct active pharmaceutical ingredient including protein intermediates for bioconjugation.
Provide hands‑on support for troubleshooting technical issues and driving innovation projects with novel ideas and technologies.
Participate in cross‑functional process development teams and effectively collaborate with other groups in BR&D, Discovery, Technical Services for Manufacturing and Manufacturing.
Support transfer of purification processes to pilot plant and manufacturing sites.
Author technical reports and regulatory documents.
Work effectively with external parties on development projects, research collaborations and outsourcing efforts.
Support organizational initiatives as needed to achieve short‑term and long‑term departmental goals.
Keep current of relevant scientific literature, new technologies/capabilities and regulatory initiatives/requirements and support their implementation, as appropriate.
Ensure work is aligned with all relevant Development Quality, Regulatory, HSE, GLP and GMP requirements.
Basic Requirements
BS/MS in Biochemistry, Chemistry, Chemical Engineering, or related field.
BS with >6 months or MS with >3 years of relevant industry experience.
Ability to work well in a team environment incorporating a variety of functional relationships and desire to be a point of accountability.
Effective oral and written communication skills, self‑management, task planning and organization.
Additional Skills And Preferences
Experience with designing experiments, generating data, interpreting results, and documenting the work independently.
Hands‑on experience with chromatography, filtration, and associated analytical techniques in an industrial R&D laboratory.
Understanding of protein downstream purification mechanisms and separation principles.
Understanding of protein structure‑function relationships and biophysical characterization is a plus.
Familiarity with AKTA systems and UNICORN software is highly desirable.
Capable of solving problems with minimal supervision.
Work productively in an interdisciplinary team environment.
The location for this position will be Lilly Technology Center North.
Additional Information Physical Demands/Travel : The physical demands of this job are consistent with a laboratory environment.
Work Environment : This position’s work environment is in a laboratory environment. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities. If you require accommodation to submit a resume for this position, please complete the accommodation request form. Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.
Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is $65,250 – $169,400. Full‑time equivalent employees will also be eligible for a company bonus (depending, in part, on company and individual performance). Lilly offers a comprehensive benefit program to eligible employees, including 401(k) participation, pension, vacation benefits, medical, dental, vision and prescription drug benefits, flexible benefits such as healthcare or dependent day‑care FSA, life insurance and death benefits, certain time‑off and leave of absence benefits, and well‑being benefits such as employee assistance programs, fitness benefits, and employee clubs and activities.
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Overview At Lilly, we serve an extraordinary purpose. We make a difference for people around the globe by discovering, developing and delivering medicines that help them live longer, healthier, more active lives. Not only do we deliver breakthrough medications, but we also develop creative solutions to support communities through philanthropy and volunteerism.
Position Summary The Bioproduct Research and Development (BR&D) organization strives to deliver innovative medicines to patients through development and commercialization of monoclonal antibodies, novel therapeutic proteins, peptides, bioconjugates, cell therapies, gene therapies and other genetic medicines. This multidisciplinary group works collaboratively with discovery, manufacturing, quality and business units. The Principal Scientist/Senior Principal Scientist is responsible for downstream purification development activities related to the production of bioproduct active pharmaceutical ingredients—including purification process definition and optimization, process robustness studies, process transfers to pilot plant and manufacturing sites, and authorship of downstream process development sections of regulatory submissions. The position will interact closely with other scientists in BR&D as well as Discovery, Technical Services for Manufacturing, and Manufacturing scientists, and will be an integral participant on multidisciplinary CMC project teams that support bioproduct process and product development activities.
Responsibilities
Design and execute appropriate purification development experiments for generation of bioproduct active pharmaceutical ingredient including protein intermediates for bioconjugation.
Provide hands‑on support for troubleshooting technical issues and driving innovation projects with novel ideas and technologies.
Participate in cross‑functional process development teams and effectively collaborate with other groups in BR&D, Discovery, Technical Services for Manufacturing and Manufacturing.
Support transfer of purification processes to pilot plant and manufacturing sites.
Author technical reports and regulatory documents.
Work effectively with external parties on development projects, research collaborations and outsourcing efforts.
Support organizational initiatives as needed to achieve short‑term and long‑term departmental goals.
Keep current of relevant scientific literature, new technologies/capabilities and regulatory initiatives/requirements and support their implementation, as appropriate.
Ensure work is aligned with all relevant Development Quality, Regulatory, HSE, GLP and GMP requirements.
Basic Requirements
BS/MS in Biochemistry, Chemistry, Chemical Engineering, or related field.
BS with >6 months or MS with >3 years of relevant industry experience.
Ability to work well in a team environment incorporating a variety of functional relationships and desire to be a point of accountability.
Effective oral and written communication skills, self‑management, task planning and organization.
Additional Skills And Preferences
Experience with designing experiments, generating data, interpreting results, and documenting the work independently.
Hands‑on experience with chromatography, filtration, and associated analytical techniques in an industrial R&D laboratory.
Understanding of protein downstream purification mechanisms and separation principles.
Understanding of protein structure‑function relationships and biophysical characterization is a plus.
Familiarity with AKTA systems and UNICORN software is highly desirable.
Capable of solving problems with minimal supervision.
Work productively in an interdisciplinary team environment.
The location for this position will be Lilly Technology Center North.
Additional Information Physical Demands/Travel : The physical demands of this job are consistent with a laboratory environment.
Work Environment : This position’s work environment is in a laboratory environment. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities. If you require accommodation to submit a resume for this position, please complete the accommodation request form. Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.
Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is $65,250 – $169,400. Full‑time equivalent employees will also be eligible for a company bonus (depending, in part, on company and individual performance). Lilly offers a comprehensive benefit program to eligible employees, including 401(k) participation, pension, vacation benefits, medical, dental, vision and prescription drug benefits, flexible benefits such as healthcare or dependent day‑care FSA, life insurance and death benefits, certain time‑off and leave of absence benefits, and well‑being benefits such as employee assistance programs, fitness benefits, and employee clubs and activities.
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