Senior Research Scientist, Cell Engagers

Position

Senior Research Scientist, Cell Engagers

Location

Cambridge, MA

Seniority Level

Mid‑Senior level

Employment Type

Full‑time

Job Function

Other (Pharmaceutical Manufacturing)

Salary Range

$137,000.00/yr – $215,270.00/yr

Responsibilities

• Contribute to discovery projects by independently designing and developing well‑defined mechanistic experiments in vitro and ex vivo for oncology cell‑engager research to identify mechanisms of action (MoA).
• Lead from the lab to advance novel and differentiated products in collaboration with cell therapy oncology toward clinical milestones, working collaboratively with internal cross‑functional teams and external partners to incorporate new Vδ1 isolation strategies for use in cell‑engager programs in vitro.
• Propose novel projects based on internal results, external partners, and published reports, and demonstrate leadership through effective communication of study plans/value and research results.
• Actively participate with the team to isolate and phenotype Vδ1 cells from blood and skin and collaborate with the Cell Therapy team to incorporate new Vδ1 isolation strategies for use in cell‑engager programs in vitro.
• Use immune cell characterization and function assessment techniques such as multi‑color flow immunophenotyping, multiplex cytokine measurement, cytotoxicity assays, and other molecular‑based assays and cell‑based functionality assays to perform analysis, interpret results, and determine appropriate action.
• Prepare and present comprehensive technical or project reports and formal presentations and posters to full range of internal/external audiences and contribute to IND reports and other regulatory filings.
• Maintain laboratory notebooks and keep them in compliance with Takeda policies.
• Independently design cytokine‑fusion strategies to enhance Vδ1 biology for solid tumors.
• Help with external collaborations/CROs and establish new protocols.
• Up to 20% remote work allowed.

Qualifications

• Master’s degree in Cancer Immunology, Immunotherapy, Cancer Sciences, or related field.
• Minimum of 5 years of related research experience.
• Experience isolating Gamma‑Delta T cells from blood and tissue and developing Gamma‑Delta T cell culture and expansion methodologies.
• Proficiency in functional and characterization experiments via flow cytometry, spectrometry, and chemiluminescence of isolated Vδ1 cells, and ability to analyze experimental data.
• Knowledge of Vδ1 γδ cell biology and ability to evaluate novel immunotherapy products based on this biology.
• Experience with gene engineering of Vδ1 cells.

Other

Full time. Salary: $137,000 - $234,800 per year.

Qualified applicants can apply at (reference job #R ). EOE.

Any individual may provide documentary evidence bearing on this application, with information on available workers and information on wages and working conditions, to the Certifying Officer, U.S. Department of Labor, Employment and Training Administration, Office of Foreign Labor Certification, 200 Constitution Avenue, NW, Room N‑5311, Washington, DC 20210.

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