BioSpace
Advisor, guide-RNA Process Development
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At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees worldwide work to discover and bring life-changing medicines to those who need them, improve disease understanding and management, and give back to communities through philanthropy and volunteerism. We give our best effort to our work and put people first. We’re looking for people who are determined to make life better for people worldwide.
Organizational Overview Verve Therapeutics, a wholly owned subsidiary of Eli Lilly & Company within Lilly Research Labs, is a clinical-stage genetic medicines company established to solve the global health epidemic of cardiovascular disease. Founded by leading experts in cardiovascular medicine, human genetics, and gene‑editing, Verve pioneers a new approach to cardiovascular care, potentially transforming treatment from chronic management to single‑course gene editing medicines. The company’s initial three programs – VERVE‑101, VERVE‑102, and VERVE‑201 – target genes extensively validated for lowering low‑density lipoprotein cholesterol (LDL‑C). VERVE‑101 and VERVE‑102 permanently turn off the PCSK9 gene in the liver, initially for heterozygous familial hypercholesterolemia (HeFH) and ultimately to treat atherosclerotic cardiovascular disease (ASCVD) patients not at goal on oral therapy. VERVE‑201 permanently turns off the ANGPTL3 gene in the liver, initially for homozygous familial hypercholesterolemia (HoFH) and ultimately to treat patients with refractory hypercholesterolemia.
Position Summary We are seeking an experienced process chemist to join the guide‑RNA process development team. The role is heavily focused on clinical manufacturing process development, primarily as a lab‑based position supporting guide‑RNA drug substance process development for programs in clinical development. The role also contributes to the development of guide‑RNA manufacturing platform technologies in a highly collaborative effort with process and analytical chemistry teams.
Responsibilities
Design and execute solid‑phase synthesis and purification experiments to support process development and scale‑up of oligonucleotide drug substance manufacturing.
Lead guide‑RNA process development efforts by identifying areas of continuous improvement through literature and state‑of‑the‑art practices and applying these learnings to Verve’s gRNA process development projects.
Collaborate cross‑functionally with process and analytical teams to progress process and manufacturing technology development projects.
Review and provide technical feedback on internal and external collaborators’ experimental designs and results.
Participate actively in technical discussions and meetings, proactively communicate technical findings and results to stakeholders, train and support teammates as needed.
Partner closely with members of facilities, lab operations, and safety to maintain the highest level of safety standards within the lab.
Keep an updated lab notebook, order materials, maintain lab equipment, and support equipment troubleshooting as needed.
Basic Requirements
PhD degree in a relevant scientific discipline with 1–2+ years of industry experience (synthesis, oligonucleotide development, solid‑phase synthesis, CMC) or an MS degree with 6+ years of relevant industry experience.
Experience designing and troubleshooting oligonucleotide solid‑phase synthesis studies; strong preference for candidates with a guide‑RNA or longmer synthesis background.
Experience with oligonucleotide manufacturing processes and equipment including solid‑phase synthesis (Cytiva OligoSynt or OP100), cleavage and deprotection, chromatography (Akta), TFF, sterile filtration, single‑use technology, and sterile/aseptic processing preferred.
Background in oligonucleotide process development, scale‑up, and GMP manufacturing.
Strong communication skills (oral and written) and ability to thrive in a team and goal‑driven environment.
Additional Skills / Preferences
Background in CRISPR guide RNA development strongly preferred.
Use of strong interpersonal skills for collaboration.
Ability to prioritize multiple activities and handle ambiguity.
Lilly is dedicated to helping individuals with disabilities actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance.
Lilly is a proud EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.
Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is $138,000 – $224,400. Full‑time employees will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company‑sponsored 401(k); pension; vacation benefits; medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day‑care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well‑being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities). Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion, and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.
#WeAreLilly
#J-18808-Ljbffr
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees worldwide work to discover and bring life-changing medicines to those who need them, improve disease understanding and management, and give back to communities through philanthropy and volunteerism. We give our best effort to our work and put people first. We’re looking for people who are determined to make life better for people worldwide.
Organizational Overview Verve Therapeutics, a wholly owned subsidiary of Eli Lilly & Company within Lilly Research Labs, is a clinical-stage genetic medicines company established to solve the global health epidemic of cardiovascular disease. Founded by leading experts in cardiovascular medicine, human genetics, and gene‑editing, Verve pioneers a new approach to cardiovascular care, potentially transforming treatment from chronic management to single‑course gene editing medicines. The company’s initial three programs – VERVE‑101, VERVE‑102, and VERVE‑201 – target genes extensively validated for lowering low‑density lipoprotein cholesterol (LDL‑C). VERVE‑101 and VERVE‑102 permanently turn off the PCSK9 gene in the liver, initially for heterozygous familial hypercholesterolemia (HeFH) and ultimately to treat atherosclerotic cardiovascular disease (ASCVD) patients not at goal on oral therapy. VERVE‑201 permanently turns off the ANGPTL3 gene in the liver, initially for homozygous familial hypercholesterolemia (HoFH) and ultimately to treat patients with refractory hypercholesterolemia.
Position Summary We are seeking an experienced process chemist to join the guide‑RNA process development team. The role is heavily focused on clinical manufacturing process development, primarily as a lab‑based position supporting guide‑RNA drug substance process development for programs in clinical development. The role also contributes to the development of guide‑RNA manufacturing platform technologies in a highly collaborative effort with process and analytical chemistry teams.
Responsibilities
Design and execute solid‑phase synthesis and purification experiments to support process development and scale‑up of oligonucleotide drug substance manufacturing.
Lead guide‑RNA process development efforts by identifying areas of continuous improvement through literature and state‑of‑the‑art practices and applying these learnings to Verve’s gRNA process development projects.
Collaborate cross‑functionally with process and analytical teams to progress process and manufacturing technology development projects.
Review and provide technical feedback on internal and external collaborators’ experimental designs and results.
Participate actively in technical discussions and meetings, proactively communicate technical findings and results to stakeholders, train and support teammates as needed.
Partner closely with members of facilities, lab operations, and safety to maintain the highest level of safety standards within the lab.
Keep an updated lab notebook, order materials, maintain lab equipment, and support equipment troubleshooting as needed.
Basic Requirements
PhD degree in a relevant scientific discipline with 1–2+ years of industry experience (synthesis, oligonucleotide development, solid‑phase synthesis, CMC) or an MS degree with 6+ years of relevant industry experience.
Experience designing and troubleshooting oligonucleotide solid‑phase synthesis studies; strong preference for candidates with a guide‑RNA or longmer synthesis background.
Experience with oligonucleotide manufacturing processes and equipment including solid‑phase synthesis (Cytiva OligoSynt or OP100), cleavage and deprotection, chromatography (Akta), TFF, sterile filtration, single‑use technology, and sterile/aseptic processing preferred.
Background in oligonucleotide process development, scale‑up, and GMP manufacturing.
Strong communication skills (oral and written) and ability to thrive in a team and goal‑driven environment.
Additional Skills / Preferences
Background in CRISPR guide RNA development strongly preferred.
Use of strong interpersonal skills for collaboration.
Ability to prioritize multiple activities and handle ambiguity.
Lilly is dedicated to helping individuals with disabilities actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance.
Lilly is a proud EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.
Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is $138,000 – $224,400. Full‑time employees will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company‑sponsored 401(k); pension; vacation benefits; medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day‑care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well‑being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities). Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion, and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.
#WeAreLilly
#J-18808-Ljbffr