Arvinas
Co‑op Biology‑Oncology
Arvinas is a clinical‑stage biotechnology company dedicated to improving the lives of patients with debilitating and life‑threatening diseases through the discovery, development, and commercialization of therapies that degrade disease‑causing proteins. The company’s proprietary PROTAC Discovery Engine platform engineers proteolysis‑targeting chimeras (PROTACs) that harness the body’s natural protein disposal system to selectively and efficiently remove disease‑causing proteins.
Position Summary
The Spring 2026 Oncology Biology Co‑Op position at Arvinas focuses on evaluating the effect of novel heterobifunctional degrader molecules on intracellular oncology targets and validating newly proposed targets for potential degrader discovery efforts. The role involves cell biology and molecular biology techniques, and may include new target proposition workflows. The candidate will collaborate with a multidisciplinary team of biologists, biochemists, biophysicists, and chemists in a laboratory setting dedicated to validating novel oncology targets through functional and mechanistic studies, including the design and execution of in‑vitro cellular assays to establish the biological rationale for PROTAC‑based therapeutic approaches.
This training opportunity allows a highly motivated individual to learn the process of early drug discovery in a collaborative environment. The position reports to a Senior Research Investigator, Biology, Oncology, and will be located at Arvinas headquarters in New Haven, CT.
Principal Responsibilities
Cell culture, including sterile technique for mammalian cell lines.
Functional genomics approaches (e.g., CRISPR KO, siRNA/shRNA KD) to interrogate targets and understand their biological function at scale or in a hypothesis‑driven manner.
Cellular assays to monitor degrader compound activity (Western blot, JESS, high‑content imaging, HiBiT, NanoBRET).
Developing and establishing new assays to detect target engagement and small‑molecule binding in vitro and in cells.
Data analysis and interpretation, and presentation of results in team meetings.
Collaborating with key stakeholders outside the project team to devise future experiments for downstream applications.
Qualifications
Highly motivated fast learner with flexibility and multitasking ability; good lab citizenship.
Required experience in cell culture, immunoblotting, and genetic perturbation assays.
Preferred prior laboratory and oncology experience.
Knowledge of ubiquitin‑based proteasomal degradation desirable but not required.
Experience with computational analysis of omics datasets (RNA‑seq, proteomics) considered an advantage.
Ability to work full‑time (40 hours per week).
Employment requires no VISA sponsorship; candidates must be legally authorized to work in the U.S. without sponsorship.
Physical and safety requirements: lift/carry 15/30 pounds, work in controlled environments with biological, infectious, and hazardous materials, use PPE, and engage in standard communication and collaboration practices.
Education
Preference for Master’s or Ph.D. students currently enrolled in programs focused on cell biology, immunology, pharmacology, biology, or related fields.
Arvinas is an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or protected veteran status.
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Position Summary
The Spring 2026 Oncology Biology Co‑Op position at Arvinas focuses on evaluating the effect of novel heterobifunctional degrader molecules on intracellular oncology targets and validating newly proposed targets for potential degrader discovery efforts. The role involves cell biology and molecular biology techniques, and may include new target proposition workflows. The candidate will collaborate with a multidisciplinary team of biologists, biochemists, biophysicists, and chemists in a laboratory setting dedicated to validating novel oncology targets through functional and mechanistic studies, including the design and execution of in‑vitro cellular assays to establish the biological rationale for PROTAC‑based therapeutic approaches.
This training opportunity allows a highly motivated individual to learn the process of early drug discovery in a collaborative environment. The position reports to a Senior Research Investigator, Biology, Oncology, and will be located at Arvinas headquarters in New Haven, CT.
Principal Responsibilities
Cell culture, including sterile technique for mammalian cell lines.
Functional genomics approaches (e.g., CRISPR KO, siRNA/shRNA KD) to interrogate targets and understand their biological function at scale or in a hypothesis‑driven manner.
Cellular assays to monitor degrader compound activity (Western blot, JESS, high‑content imaging, HiBiT, NanoBRET).
Developing and establishing new assays to detect target engagement and small‑molecule binding in vitro and in cells.
Data analysis and interpretation, and presentation of results in team meetings.
Collaborating with key stakeholders outside the project team to devise future experiments for downstream applications.
Qualifications
Highly motivated fast learner with flexibility and multitasking ability; good lab citizenship.
Required experience in cell culture, immunoblotting, and genetic perturbation assays.
Preferred prior laboratory and oncology experience.
Knowledge of ubiquitin‑based proteasomal degradation desirable but not required.
Experience with computational analysis of omics datasets (RNA‑seq, proteomics) considered an advantage.
Ability to work full‑time (40 hours per week).
Employment requires no VISA sponsorship; candidates must be legally authorized to work in the U.S. without sponsorship.
Physical and safety requirements: lift/carry 15/30 pounds, work in controlled environments with biological, infectious, and hazardous materials, use PPE, and engage in standard communication and collaboration practices.
Education
Preference for Master’s or Ph.D. students currently enrolled in programs focused on cell biology, immunology, pharmacology, biology, or related fields.
Arvinas is an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or protected veteran status.
#J-18808-Ljbffr