EyeBio
Principal Scientist, Translational PET Imaging
EyeBio, Oklahoma City, Oklahoma, United States
Job Description
We are seeking a motivated and experienced Translational PET Imaging Scientist to lead the transition of novel PET radiotracers from late preclinical development into first‑in‑human studies. This role will primarily focus on clinical implementation of novel PET tracers in oncology studies, guide regulatory submissions, and act as the PET imaging expert within multidisciplinary project teams to ensure efficient clinical translation.
Key Responsibilities
Strategy & Leadership:
Develop and lead the clinical imaging strategy for application of novel PET tracers in early clinical oncology trials, guiding projects from late‑stage preclinical work through clinical proof‑of‑concept studies.
Translational Study Design:
Design, oversee, and interpret PET imaging studies in animal models and early‑phase clinical trials (Phase I), ensuring robust study design and high‑quality PET data collection.
Regulatory Support:
Familiarity with regulatory and quality frameworks applicable to radiopharmaceuticals (GMP for radiopharmaceuticals, IND/CTA requirements, radiation safety/compliance). Prepare and contribute PET‑specific scientific content for regulatory filings, including IND submissions.
Partner and Site Management:
Coordinate with CROs, CDMOs, and clinical sites to support cGMP manufacturing logistics and clinical supply/distribution for radiopharmaceuticals. Manage relationships and deliverables with external academic collaborators and CROs/CDMOs.
Cross‑functional Collaboration:
Serve as the PET imaging subject‑matter expert on project teams, working closely with biomarker scientists, clinical and medical leads, regulatory affairs, clinical operations, and CMC teams.
Reporting & Dissemination:
Interpret imaging data, author study reports, present findings internally and externally, and contribute to manuscripts and conference presentations.
NOTE: This role is available in South San Francisco, CA; Boston, MA; West Point, PA or Rahway, NJ based on candidate preference.
Qualifications Education
Ph.D. or equivalent doctorate degree in Biomedical/Imaging Science, Radiochemistry, Physics, Pharmacology or a related field and seven (7) years of relevant experience.
Required Experience and Skills
Demonstrated experience advancing novel PET tracers into clinical studies, including collaboration with academic sites and contract partners for cGMP manufacturing.
Experience as imaging lead on Phase I oncology trials and direct involvement in first‑in‑human novel PET tracer studies, including lead contributor to protocol design.
Strong understanding of radiopharmaceutical development, radiochemistry, and quality control; proven ability designing quantitative PET studies across species.
First‑hand experience with regulatory pathways and requirements for novel PET tracers in early‑phase clinical trials.
Track record of interacting with regulatory agencies or primary contributor to successful agency submissions for novel PET imaging agents.
Excellent written and verbal communication skills, with a track record of effective collaboration across multidisciplinary teams.
Required Skills
Cancer Research
Clinical Trials
Oncology
Oncology Trials
Positron Emission Tomography (PET)
Project Leadership
Radiation Safety
Radiopharmaceuticals
Radiopharmacy
Regulatory Compliance
Regulatory Work
Technical Leadership
Translational Research
Preferred Skills Current Employees apply.
Current Contingent Workers apply.
We are committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. If you need an accommodation during the application or hiring process, please provide a notice.
Equal Employment Opportunity Statement We are an Equal Employment Opportunity Employer. We provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities.
U.S. Hybrid Work Model Effective September 5, 2023, employees in office‑based positions in the U.S. will be working a hybrid schedule consisting of three total days on site per week, Monday – Thursday, with Friday designated as a remote‑working day, unless business critical tasks require an on‑site presence. This model does not apply to field‑based, manufacturing‑based, or research‑based positions that require on‑site attendance, nor to positions covered by a collective‑bargaining agreement or other roles with job requirements that cannot be reasonably met by remote work. Positions designated as “remote” are exempt from this guidance.
The salary range for this role is $169,700.00 – $267,200.00. This range reflects the current market and will be adjusted based on education, qualifications, certifications, experience, skills, geographic location and other factors.
Benefits include medical, dental, vision, health insurance, retirement benefits (401(k)), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits.
You can apply for this role through https://jobs.merck.com/us/en. The application deadline for this position is stated on this posting.
San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance.
Los Angeles Residents Only: We will consider all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance.
Merck & Co., Inc. does not accept unsolicited assistance from search firms for employment opportunities. All CVs and resumes submitted by search firms without a valid written search agreement will be deemed the sole property of our company. No fee will be paid if no pre‑existing agreement is in place.
Employee Status: Regular
Relocation: Domestic/International
VISA Sponsorship: Yes
Travel Requirements: 10%
Flexible Work Arrangements: Hybrid
Shift: 1st – Day
Valid Driving License: No
Hazardous Material(s): N/A
Job Posting End Date: 01/31/2026
*A job posting is effective until 11:59:59 PM on the day before the listed job posting end date. Please ensure you apply to a job posting no later than the day before the job posting end date.
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Key Responsibilities
Strategy & Leadership:
Develop and lead the clinical imaging strategy for application of novel PET tracers in early clinical oncology trials, guiding projects from late‑stage preclinical work through clinical proof‑of‑concept studies.
Translational Study Design:
Design, oversee, and interpret PET imaging studies in animal models and early‑phase clinical trials (Phase I), ensuring robust study design and high‑quality PET data collection.
Regulatory Support:
Familiarity with regulatory and quality frameworks applicable to radiopharmaceuticals (GMP for radiopharmaceuticals, IND/CTA requirements, radiation safety/compliance). Prepare and contribute PET‑specific scientific content for regulatory filings, including IND submissions.
Partner and Site Management:
Coordinate with CROs, CDMOs, and clinical sites to support cGMP manufacturing logistics and clinical supply/distribution for radiopharmaceuticals. Manage relationships and deliverables with external academic collaborators and CROs/CDMOs.
Cross‑functional Collaboration:
Serve as the PET imaging subject‑matter expert on project teams, working closely with biomarker scientists, clinical and medical leads, regulatory affairs, clinical operations, and CMC teams.
Reporting & Dissemination:
Interpret imaging data, author study reports, present findings internally and externally, and contribute to manuscripts and conference presentations.
NOTE: This role is available in South San Francisco, CA; Boston, MA; West Point, PA or Rahway, NJ based on candidate preference.
Qualifications Education
Ph.D. or equivalent doctorate degree in Biomedical/Imaging Science, Radiochemistry, Physics, Pharmacology or a related field and seven (7) years of relevant experience.
Required Experience and Skills
Demonstrated experience advancing novel PET tracers into clinical studies, including collaboration with academic sites and contract partners for cGMP manufacturing.
Experience as imaging lead on Phase I oncology trials and direct involvement in first‑in‑human novel PET tracer studies, including lead contributor to protocol design.
Strong understanding of radiopharmaceutical development, radiochemistry, and quality control; proven ability designing quantitative PET studies across species.
First‑hand experience with regulatory pathways and requirements for novel PET tracers in early‑phase clinical trials.
Track record of interacting with regulatory agencies or primary contributor to successful agency submissions for novel PET imaging agents.
Excellent written and verbal communication skills, with a track record of effective collaboration across multidisciplinary teams.
Required Skills
Cancer Research
Clinical Trials
Oncology
Oncology Trials
Positron Emission Tomography (PET)
Project Leadership
Radiation Safety
Radiopharmaceuticals
Radiopharmacy
Regulatory Compliance
Regulatory Work
Technical Leadership
Translational Research
Preferred Skills Current Employees apply.
Current Contingent Workers apply.
We are committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. If you need an accommodation during the application or hiring process, please provide a notice.
Equal Employment Opportunity Statement We are an Equal Employment Opportunity Employer. We provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities.
U.S. Hybrid Work Model Effective September 5, 2023, employees in office‑based positions in the U.S. will be working a hybrid schedule consisting of three total days on site per week, Monday – Thursday, with Friday designated as a remote‑working day, unless business critical tasks require an on‑site presence. This model does not apply to field‑based, manufacturing‑based, or research‑based positions that require on‑site attendance, nor to positions covered by a collective‑bargaining agreement or other roles with job requirements that cannot be reasonably met by remote work. Positions designated as “remote” are exempt from this guidance.
The salary range for this role is $169,700.00 – $267,200.00. This range reflects the current market and will be adjusted based on education, qualifications, certifications, experience, skills, geographic location and other factors.
Benefits include medical, dental, vision, health insurance, retirement benefits (401(k)), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits.
You can apply for this role through https://jobs.merck.com/us/en. The application deadline for this position is stated on this posting.
San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance.
Los Angeles Residents Only: We will consider all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance.
Merck & Co., Inc. does not accept unsolicited assistance from search firms for employment opportunities. All CVs and resumes submitted by search firms without a valid written search agreement will be deemed the sole property of our company. No fee will be paid if no pre‑existing agreement is in place.
Employee Status: Regular
Relocation: Domestic/International
VISA Sponsorship: Yes
Travel Requirements: 10%
Flexible Work Arrangements: Hybrid
Shift: 1st – Day
Valid Driving License: No
Hazardous Material(s): N/A
Job Posting End Date: 01/31/2026
*A job posting is effective until 11:59:59 PM on the day before the listed job posting end date. Please ensure you apply to a job posting no later than the day before the job posting end date.
#J-18808-Ljbffr