Merck
Associate Principal Scientist, Continuous & Expression Technologies (Downstream
Merck, Rahway, New Jersey, us, 07065
Associate Principal Scientist, Continuous & Expression Technologies (Downstream) – Onsite
Merck – Rahway, NJ
Join to apply for the Associate Principal Scientist, Continuous & Expression Technologies (Downstream) – Onsite role at Merck.
Job Description The Continuous & Expression Technologies (CET) Group within the Process Research & Development, Enabling Technologies department is seeking motivated and creative individuals. This is an opportunity to positively impact our company’s manufacturing platforms while actively supporting drug development in the biologics and vaccine arenas. CET is seeking an Associate Principal Scientist specializing in bioprocessing purification technologies for multiple therapeutic classes – at our site in Rahway, NJ.
Responsibilities
As an impactful contributor, shape and realize innovation across biologics’ pipeline, strategy, and science
Advance best science incorporation into pipeline by collaborating with cross‑functional teams, from Research & Manufacturing, in a fast‑paced, multidisciplinary environment
Lead development of robust and scalable technologies for downstream processes for biologics
Identify areas for downstream process innovation/intensification and expand our technologies toolbox to address challenges at different stages of development (clinical, process characterization and commercialization)
Contribute to strategic initiatives; partner with senior leaders to set overall project strategy, and guide teams towards its execution
Conceptualize, plan, and execute projects with effective organizational, prioritization and problem‑solving skills
Stay abreast of scientific and regulatory landscape; actively present (premier conferences), publish (peer‑reviewed journals) and patent
Serve as Subject Matter Expert for intensified and/or continuous bioprocessing
Mentor and actively share expertise; guide career development; build strong, collaborative teams
Minimum Education Requirements
Ph.D. with 3+ years, MS with 5+ years, or BS with 8+ years of industry experience and background in Chemical/Biochemical engineering, or a related field
Required Experience, Skills, and Competencies
Strong fundamental knowledge and subject matter expertise in downstream process development
Experience in continuous biomanufacturing and experimentation with integrated purification steps
Expertise in independently conducting and directing the design, execution, analysis, and documentation of all stages of downstream process development
Track record of accomplishments in downstream bioprocessing with a history of peer‑reviewed publications and presentations
Adaptability and agility to prioritize and deliver complex objectives, often on tight timelines, in a rapidly changing environment
Experience and aptitude to lead, work, and collaborate in internal and external cross‑functional, matrixed teams
Action‑oriented mindset for creativity; ability to take initiative, innovate, iterate, and problem‑solve
Demonstrated commitment to coach and mentor staff to maximize talent development and utilization
Excellent interpersonal and communication skills
Preferred Experience & Skills
Excellent interpersonal and communication skills
Experience with purification steps integrated with process‑analytical technologies
High‑throughput experimentation, automation, and process control
Experience with single‑pass ultrafiltration and in‑line diafiltration
Experience with high throughput experimentation using automation platforms such as TECAN
Experience using and/or programming process control systems such as DeltaV or PCS 7
Experience with multi‑column chromatography systems (BioSMB, PCC, or similar)
Experience with statistical data analysis tools and design of experiments (JMP, Design Expert)
Experience with multivariate data analysis, machine learning, artificial intelligence
Experience with process modeling packages such as BioSolve Process, gPROMS, SuperPro Designer, or similar
Required Skills
Accountability
Artificial Intelligence (AI)
Automation
Biomanufacturing
Career Development
Cell Line Development
Column Chromatography
Continuous Deployment
Detail‑Oriented
Downstream Process Development
Drug Delivery Technology
Drug Development
Expression Vectors
Innovation
Interpersonal Relationships
Leading Project Teams
Machine Learning (ML)
Molecular Biology
Pharmaceutical Formulations
Pharmaceutical Process Development
Physical Characterization
Process Automations
Project Prioritization
Software Integration
+4 more
Preferred Skills Current Employees apply HERE | Current Contingent Workers apply HERE
US And Puerto Rico Residents Only Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.
Requirements As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status or other applicable legally protected characteristics.
As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit: EEOC Know Your Rights | EEOC GINA Supplement | We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.
U.S. Hybrid Work Model Effective September 5, 2023, employees in office‑based positions in the U.S. will be working a Hybrid work consisting of three total days on‑site per week, Monday – Thursday, although the specific days may vary by site or organization, with Friday designated as a remote‑working day, unless business critical tasks require an on‑site presence. This Hybrid work model does not apply to, and daily in‑person attendance is required for, field‑based positions; facility‑based, manufacturing‑based, or research‑based positions where the work to be performed is located at a Company site; positions covered by a collective‑bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as “remote”.
Salary Range $139,600.00 – $219,700.00 (lowest to highest salary we in good faith believe we would pay for this role at the time of this posting). An employee’s position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs.
Benefits We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits.
Application You can apply for this role through https://jobs.merck.com/us/en (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting.
San Francisco Residents Only We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance.
Los Angeles Residents Only We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance.
Employee Status Regular
Relocation Domestic
VISA Sponsorship Yes
Travel Requirements 10%
Flexible Work Arrangements Not Applicable
Shift Not Indicated
Valid Driving License No
Hazardous Material(s) n/a
Job Posting End Date Job posting is effective until 11:59:59 PM on the day before the listed job posting end date. Please ensure you apply to a job posting no later than the day before the job posting end date. Job Posting End Date: 01/16/2026.
Requisition ID R378849
Seniority level
Associate
Employment type
Full‑time
Job function
Research, Analyst, and Information Technology
Industries
Pharmaceutical Manufacturing, Biotechnology Research, and Research Services
#J-18808-Ljbffr
Join to apply for the Associate Principal Scientist, Continuous & Expression Technologies (Downstream) – Onsite role at Merck.
Job Description The Continuous & Expression Technologies (CET) Group within the Process Research & Development, Enabling Technologies department is seeking motivated and creative individuals. This is an opportunity to positively impact our company’s manufacturing platforms while actively supporting drug development in the biologics and vaccine arenas. CET is seeking an Associate Principal Scientist specializing in bioprocessing purification technologies for multiple therapeutic classes – at our site in Rahway, NJ.
Responsibilities
As an impactful contributor, shape and realize innovation across biologics’ pipeline, strategy, and science
Advance best science incorporation into pipeline by collaborating with cross‑functional teams, from Research & Manufacturing, in a fast‑paced, multidisciplinary environment
Lead development of robust and scalable technologies for downstream processes for biologics
Identify areas for downstream process innovation/intensification and expand our technologies toolbox to address challenges at different stages of development (clinical, process characterization and commercialization)
Contribute to strategic initiatives; partner with senior leaders to set overall project strategy, and guide teams towards its execution
Conceptualize, plan, and execute projects with effective organizational, prioritization and problem‑solving skills
Stay abreast of scientific and regulatory landscape; actively present (premier conferences), publish (peer‑reviewed journals) and patent
Serve as Subject Matter Expert for intensified and/or continuous bioprocessing
Mentor and actively share expertise; guide career development; build strong, collaborative teams
Minimum Education Requirements
Ph.D. with 3+ years, MS with 5+ years, or BS with 8+ years of industry experience and background in Chemical/Biochemical engineering, or a related field
Required Experience, Skills, and Competencies
Strong fundamental knowledge and subject matter expertise in downstream process development
Experience in continuous biomanufacturing and experimentation with integrated purification steps
Expertise in independently conducting and directing the design, execution, analysis, and documentation of all stages of downstream process development
Track record of accomplishments in downstream bioprocessing with a history of peer‑reviewed publications and presentations
Adaptability and agility to prioritize and deliver complex objectives, often on tight timelines, in a rapidly changing environment
Experience and aptitude to lead, work, and collaborate in internal and external cross‑functional, matrixed teams
Action‑oriented mindset for creativity; ability to take initiative, innovate, iterate, and problem‑solve
Demonstrated commitment to coach and mentor staff to maximize talent development and utilization
Excellent interpersonal and communication skills
Preferred Experience & Skills
Excellent interpersonal and communication skills
Experience with purification steps integrated with process‑analytical technologies
High‑throughput experimentation, automation, and process control
Experience with single‑pass ultrafiltration and in‑line diafiltration
Experience with high throughput experimentation using automation platforms such as TECAN
Experience using and/or programming process control systems such as DeltaV or PCS 7
Experience with multi‑column chromatography systems (BioSMB, PCC, or similar)
Experience with statistical data analysis tools and design of experiments (JMP, Design Expert)
Experience with multivariate data analysis, machine learning, artificial intelligence
Experience with process modeling packages such as BioSolve Process, gPROMS, SuperPro Designer, or similar
Required Skills
Accountability
Artificial Intelligence (AI)
Automation
Biomanufacturing
Career Development
Cell Line Development
Column Chromatography
Continuous Deployment
Detail‑Oriented
Downstream Process Development
Drug Delivery Technology
Drug Development
Expression Vectors
Innovation
Interpersonal Relationships
Leading Project Teams
Machine Learning (ML)
Molecular Biology
Pharmaceutical Formulations
Pharmaceutical Process Development
Physical Characterization
Process Automations
Project Prioritization
Software Integration
+4 more
Preferred Skills Current Employees apply HERE | Current Contingent Workers apply HERE
US And Puerto Rico Residents Only Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.
Requirements As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status or other applicable legally protected characteristics.
As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit: EEOC Know Your Rights | EEOC GINA Supplement | We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.
U.S. Hybrid Work Model Effective September 5, 2023, employees in office‑based positions in the U.S. will be working a Hybrid work consisting of three total days on‑site per week, Monday – Thursday, although the specific days may vary by site or organization, with Friday designated as a remote‑working day, unless business critical tasks require an on‑site presence. This Hybrid work model does not apply to, and daily in‑person attendance is required for, field‑based positions; facility‑based, manufacturing‑based, or research‑based positions where the work to be performed is located at a Company site; positions covered by a collective‑bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as “remote”.
Salary Range $139,600.00 – $219,700.00 (lowest to highest salary we in good faith believe we would pay for this role at the time of this posting). An employee’s position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs.
Benefits We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits.
Application You can apply for this role through https://jobs.merck.com/us/en (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting.
San Francisco Residents Only We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance.
Los Angeles Residents Only We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance.
Employee Status Regular
Relocation Domestic
VISA Sponsorship Yes
Travel Requirements 10%
Flexible Work Arrangements Not Applicable
Shift Not Indicated
Valid Driving License No
Hazardous Material(s) n/a
Job Posting End Date Job posting is effective until 11:59:59 PM on the day before the listed job posting end date. Please ensure you apply to a job posting no later than the day before the job posting end date. Job Posting End Date: 01/16/2026.
Requisition ID R378849
Seniority level
Associate
Employment type
Full‑time
Job function
Research, Analyst, and Information Technology
Industries
Pharmaceutical Manufacturing, Biotechnology Research, and Research Services
#J-18808-Ljbffr