US Tech Solutions, Inc.
Scientist, Biologics LCMS Bioanalysis - Biologist II/III
US Tech Solutions, Inc., Worcester, Massachusetts, United States
Duration: 6 months contract
Work schedule:
Monday – Friday 9-5. No OT offered or required.
Description:
The
Quantitative, Translational ADME
Sciences
department is seeking a highly motivated and energetic
Bioanalytical Scientist
to join the
biologics bioanalysis, characterization and proteomics (BBCP) group . The primary responsibility of this position is to
support LC-MS (liquid chromatography-mass spectrometry)-based bioanalysis
and
method development
for biologic entities, such as
monoclonal antibodies, multi-specific antibodies, antibody-drug conjugates (ADCs),
and other novel modalities. The successful candidate will have experience in optimizing and implementing hybrid LC-MS-based bioanalytical methods to support non-regulated preclinical PK and TK studies. Responsibilities include routine sample preparation, method development, instrument maintenance, data analysis, report writing, and presenting data at internal and external meetings.
Responsibilities:
Perform
affinity purification and digestion of biological therapeutics
(including but not limited to monoclonal and bispecific antibodies, antibody drug conjugates, antibody-siRNA conjugates, and fusion proteins) from biological matrices manually or using automation systems. Operate and maintain LC/MS instruments
to generate high-quality experimental data. Optimize and develop LC/MS methods
to meet assay specificity and sensitivity requirements. Analyze data and maintain detailed, accurate and comprehensive study documentation in electronic laboratory notebooks. Communicate data interpretation internally and externally.
Top skill requirements:
Prior industry experience in
drug discovery/development
highly desired. Hands-on experience with
QQQ (SCIEX) Mass Spectrometer
required, additional experience with
qTOF (Agilent, Bruker, SCIEX) and/or Orbitrap (Thermo) mass spectrometers
a plus. Hands-on experience with
biologics bioanalysis
highly desired, additional experience with
oligonucleotide analysis
a plus. Hands-on experience with
immuno-affinity purification
and
automation
systems (e.g.,
TECAN, AssayMap Bravo or Hamilton ) highly desired. Highly motivated, self-driven and results-oriented with communication and presentation skills; capable of working both as a team player and individual contributor. In-depth understanding of
PK, TK and PK/PD studies
is preferred. Open to a Biologist III.
Education and experience:
Degree in
Chemistry, Pharmacology
or related fields. BS with 5+ years or MS with 2+ years in
pharmaceutical industry
setting with a focus on mass spectrometry.
About US Tech Solutions: US Tech Solutions is a global staff augmentation firm providing a wide range of talent on-demand and total workforce solutions. To know more about US Tech Solutions, please visit
www.ustechsolutions.com
.
US Tech Solutions is an Equal Opportunity Employer.
All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.
Work schedule:
Monday – Friday 9-5. No OT offered or required.
Description:
The
Quantitative, Translational ADME
Sciences
department is seeking a highly motivated and energetic
Bioanalytical Scientist
to join the
biologics bioanalysis, characterization and proteomics (BBCP) group . The primary responsibility of this position is to
support LC-MS (liquid chromatography-mass spectrometry)-based bioanalysis
and
method development
for biologic entities, such as
monoclonal antibodies, multi-specific antibodies, antibody-drug conjugates (ADCs),
and other novel modalities. The successful candidate will have experience in optimizing and implementing hybrid LC-MS-based bioanalytical methods to support non-regulated preclinical PK and TK studies. Responsibilities include routine sample preparation, method development, instrument maintenance, data analysis, report writing, and presenting data at internal and external meetings.
Responsibilities:
Perform
affinity purification and digestion of biological therapeutics
(including but not limited to monoclonal and bispecific antibodies, antibody drug conjugates, antibody-siRNA conjugates, and fusion proteins) from biological matrices manually or using automation systems. Operate and maintain LC/MS instruments
to generate high-quality experimental data. Optimize and develop LC/MS methods
to meet assay specificity and sensitivity requirements. Analyze data and maintain detailed, accurate and comprehensive study documentation in electronic laboratory notebooks. Communicate data interpretation internally and externally.
Top skill requirements:
Prior industry experience in
drug discovery/development
highly desired. Hands-on experience with
QQQ (SCIEX) Mass Spectrometer
required, additional experience with
qTOF (Agilent, Bruker, SCIEX) and/or Orbitrap (Thermo) mass spectrometers
a plus. Hands-on experience with
biologics bioanalysis
highly desired, additional experience with
oligonucleotide analysis
a plus. Hands-on experience with
immuno-affinity purification
and
automation
systems (e.g.,
TECAN, AssayMap Bravo or Hamilton ) highly desired. Highly motivated, self-driven and results-oriented with communication and presentation skills; capable of working both as a team player and individual contributor. In-depth understanding of
PK, TK and PK/PD studies
is preferred. Open to a Biologist III.
Education and experience:
Degree in
Chemistry, Pharmacology
or related fields. BS with 5+ years or MS with 2+ years in
pharmaceutical industry
setting with a focus on mass spectrometry.
About US Tech Solutions: US Tech Solutions is a global staff augmentation firm providing a wide range of talent on-demand and total workforce solutions. To know more about US Tech Solutions, please visit
www.ustechsolutions.com
.
US Tech Solutions is an Equal Opportunity Employer.
All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.