Arrowhead Pharmaceuticals
Associate Scientist I, Discovery Chemistry (Bioconjugation)
Arrowhead Pharmaceuticals, San Diego, California, United States, 92189
Associate Scientist I, Discovery Chemistry (Bioconjugation)
Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.
Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.
Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.
The Position
Arrowhead is seeking a highly motivated Associate Scientist to join our growing Discovery Chemistry team at our San Diego site. This individual will primarily focus on oligonucleotide bioconjugation, peptide synthesis, purification, and analytical chemistry. As a discovery chemist, you will play a key role in the development and optimization of siRNA-based therapeutics by applying your expertise in bioconjugation strategies and peptide chemistry.
Responsibilities
Maintain a well-documented laboratory notebook
Track progress against project timelines, generate regular status updates, and communicate progress and issues to management
Perform tasks across projects
Manage time effectively to meet deadlines
Adhere to safe laboratory practices
Prioritize and perform synthesis, purification, and analysis of conjugates based on project deliverable timelines
Requirements:
B.S. or M.S. Chemistry or Biochemistry degree with excellent understanding of organic and analytical chemistry
0-3 years of experience working in a chemistry laboratory
Experience with a wide range of analytical techniques, especially HPLC
Ability to quickly learn new procedures and techniques
Preferred:
Experience working with large-molecule synthetic targets, particularly oligonucleotides, in an academic or industry setting
Experience with solid-phase peptide synthesis (automated and/or manual)
Prior experience in a pharmaceutical or biotechnology environment
Arrowhead provides competitive salaries and an excellent benefit packagep>
All applicants must have authorization to work in the US for a company.
California Applicant Privacy Policy
Seniority level
Entry level
Employment type
Full-time
Job function
Research
#J-18808-Ljbffr
Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.
Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.
The Position
Arrowhead is seeking a highly motivated Associate Scientist to join our growing Discovery Chemistry team at our San Diego site. This individual will primarily focus on oligonucleotide bioconjugation, peptide synthesis, purification, and analytical chemistry. As a discovery chemist, you will play a key role in the development and optimization of siRNA-based therapeutics by applying your expertise in bioconjugation strategies and peptide chemistry.
Responsibilities
Maintain a well-documented laboratory notebook
Track progress against project timelines, generate regular status updates, and communicate progress and issues to management
Perform tasks across projects
Manage time effectively to meet deadlines
Adhere to safe laboratory practices
Prioritize and perform synthesis, purification, and analysis of conjugates based on project deliverable timelines
Requirements:
B.S. or M.S. Chemistry or Biochemistry degree with excellent understanding of organic and analytical chemistry
0-3 years of experience working in a chemistry laboratory
Experience with a wide range of analytical techniques, especially HPLC
Ability to quickly learn new procedures and techniques
Preferred:
Experience working with large-molecule synthetic targets, particularly oligonucleotides, in an academic or industry setting
Experience with solid-phase peptide synthesis (automated and/or manual)
Prior experience in a pharmaceutical or biotechnology environment
Arrowhead provides competitive salaries and an excellent benefit packagep>
All applicants must have authorization to work in the US for a company.
California Applicant Privacy Policy
Seniority level
Entry level
Employment type
Full-time
Job function
Research
#J-18808-Ljbffr