AstraZeneca
Project Toxicologist, Director – Oncology Targeted Delivery (OTD) Safety Science
AstraZeneca, Waltham, Massachusetts, United States, 02254
Project Toxicologist, Director – Oncology Targeted Delivery (OTD) Safety Science, Clinical Pharmacology and Safety Sciences
Join to apply for the
Project Toxicologist, Director – Oncology Targeted Delivery (OTD) Safety Science, Clinical Pharmacology and Safety Sciences
role at
AstraZeneca .
At AstraZeneca, our bold ambition is to eliminate cancer as a cause of death. We are building a rich pipeline of innovative therapeutics and our Onco‑Targeted Delivery (OTD) Safety team accelerates expert non‑clinical safety science to support these efforts.
This position will be based at one of our R&D sites in the Boston Area, MA or Gaithersburg, MD (Washington DC area). The role is a 60 % onsite hybrid position and reporting to the OTD Safety leadership.
Key Responsibilities
Design regulatory and investigative toxicology studies and devise strategies to predict, assess, and mitigate target‑ and modality‑related safety risks across Radio Conjugates, Antibody‑Drug Conjugates, and Small Molecules.
Apply toxicology expertise to predict clinical safety risks and inform decision‑making in drug‑discovery and development programs.
Develop and implement innovative solutions that combine regulatory toxicology with cutting‑edge science and technologies to advance novel drug candidates to the clinic.
Communicate clear positions on integrated risk assessments in various formats, including informing governance bodies and contributing to regulatory submissions.
Maintain expertise in regulatory requirements and preclinical safety approaches applicable to relevant modalities and stay informed of industry trends.
Provide specialist non‑clinical safety expertise for the evaluation of in‑licensing opportunities.
Build oncology safety science through collaborative networks across AstraZeneca R&D, external collaborations, and publications.
Qualifications
PhD or DABT in Toxicology, Pharmacology, Oncology, or a related field with a strong scientific track record.
Minimum 10 years of relevant professional experience as a Project Toxicologist, Investigative Toxicologist, or a similar safety‑focused role in the pharmaceutical/biotech/CRO ecosystem.
Demonstrated understanding of drug discovery and development and a proven record of delivering toxicology programs that enable progression of candidates into the clinic.
Expertise in oncology and preferably a solid understanding of the safety aspects of Radio Conjugates or ADCs.
Experience delivering non‑clinical toxicology studies in support of IND applications.
Proficiency in using in vitro, in silico, and in vivo approaches to predict clinical risks for oncology therapeutics, with familiarity in organ‑on‑chip, imaging, and omics for mechanistic insight.
Team‑oriented, problem‑solving mindset able to coordinate across multiple projects and work independently to deliver toxicology risk assessments in drug development.
Excellent communication, presentation, interpersonal and influencing skills across levels and subject areas with a strong desire to drive personal development.
Inclusive and collegial working style with awareness of inclusion and diversity; experience working with global teams.
Benefits
Competitive base salary ranging from $178,540.80 to $267,811.20 USD annually.
Short‑term incentive bonus opportunity.
Eligibility to participate in equity‑based long‑term incentive program and retirement contribution plans.
Qualifying retirement plan (401(k) plan), paid vacation and holidays, paid leaves, and comprehensive health benefits (medical, prescription drug, dental, and vision) in accordance with applicable plans.
At‑will employment with flexibility in salary and discretionary benefits.
Date Posted:
19-Dec-2025
Closing Date:
22-Jan-2026
Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. We welcome and consider applications from all qualified candidates, regardless of protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.
#J-18808-Ljbffr
Join to apply for the
Project Toxicologist, Director – Oncology Targeted Delivery (OTD) Safety Science, Clinical Pharmacology and Safety Sciences
role at
AstraZeneca .
At AstraZeneca, our bold ambition is to eliminate cancer as a cause of death. We are building a rich pipeline of innovative therapeutics and our Onco‑Targeted Delivery (OTD) Safety team accelerates expert non‑clinical safety science to support these efforts.
This position will be based at one of our R&D sites in the Boston Area, MA or Gaithersburg, MD (Washington DC area). The role is a 60 % onsite hybrid position and reporting to the OTD Safety leadership.
Key Responsibilities
Design regulatory and investigative toxicology studies and devise strategies to predict, assess, and mitigate target‑ and modality‑related safety risks across Radio Conjugates, Antibody‑Drug Conjugates, and Small Molecules.
Apply toxicology expertise to predict clinical safety risks and inform decision‑making in drug‑discovery and development programs.
Develop and implement innovative solutions that combine regulatory toxicology with cutting‑edge science and technologies to advance novel drug candidates to the clinic.
Communicate clear positions on integrated risk assessments in various formats, including informing governance bodies and contributing to regulatory submissions.
Maintain expertise in regulatory requirements and preclinical safety approaches applicable to relevant modalities and stay informed of industry trends.
Provide specialist non‑clinical safety expertise for the evaluation of in‑licensing opportunities.
Build oncology safety science through collaborative networks across AstraZeneca R&D, external collaborations, and publications.
Qualifications
PhD or DABT in Toxicology, Pharmacology, Oncology, or a related field with a strong scientific track record.
Minimum 10 years of relevant professional experience as a Project Toxicologist, Investigative Toxicologist, or a similar safety‑focused role in the pharmaceutical/biotech/CRO ecosystem.
Demonstrated understanding of drug discovery and development and a proven record of delivering toxicology programs that enable progression of candidates into the clinic.
Expertise in oncology and preferably a solid understanding of the safety aspects of Radio Conjugates or ADCs.
Experience delivering non‑clinical toxicology studies in support of IND applications.
Proficiency in using in vitro, in silico, and in vivo approaches to predict clinical risks for oncology therapeutics, with familiarity in organ‑on‑chip, imaging, and omics for mechanistic insight.
Team‑oriented, problem‑solving mindset able to coordinate across multiple projects and work independently to deliver toxicology risk assessments in drug development.
Excellent communication, presentation, interpersonal and influencing skills across levels and subject areas with a strong desire to drive personal development.
Inclusive and collegial working style with awareness of inclusion and diversity; experience working with global teams.
Benefits
Competitive base salary ranging from $178,540.80 to $267,811.20 USD annually.
Short‑term incentive bonus opportunity.
Eligibility to participate in equity‑based long‑term incentive program and retirement contribution plans.
Qualifying retirement plan (401(k) plan), paid vacation and holidays, paid leaves, and comprehensive health benefits (medical, prescription drug, dental, and vision) in accordance with applicable plans.
At‑will employment with flexibility in salary and discretionary benefits.
Date Posted:
19-Dec-2025
Closing Date:
22-Jan-2026
Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. We welcome and consider applications from all qualified candidates, regardless of protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.
#J-18808-Ljbffr