MapLight Therapeutics
Senior Director, Early Clinical Development
MapLight Therapeutics, Burlington, Massachusetts, us, 01805
Senior Director, Early Clinical Development
Burlington, MA
Who We Are:
MapLight Therapeutics is a clinical stage biotech company that focuses on drug discovery for central nervous system disorders. We combine cutting‑edge technologies including optogenetics, in vivo physiology, and spatial transcriptomics to identify novel drug targets and develop effective therapies to address psychiatric symptoms.
Key Responsibilities:
Lead, in partnership with Clinical Pharmacology, early clinical development plans and Phase 1 studies of CNS assets
Provide clear and insightful clinical and scientific expertise to advance the transition of compounds from discovery to full development
Align development plans and studies with corporate and departmental objectives
Design, execute, monitor, and interpret studies from concept to final report
Incorporate mechanistic insights and translational relevance into study designs, including the use of biomarkers and innovative designs
Ensure studies meet ethical, regulatory, and scientific standards and are delivered with the highest quality and within approved timelines and budget
Support regulatory submissions by preparing high‑quality contributions to INDs, NDAs, MAAs, and other regulatory documents
Represent the company at scientific meetings, advisory boards, and regulatory interactions
Publish and present clinical and translational findings to enhance the company’s scientific reputation
Support initiatives to foster a culture of scientific rigor, innovation, collegiality, and accountability across the development organization
Behaviors:
We consider these behaviors we seek in all MapLight employees
You participate and work effectively with multiple cross‑functional teams
You have strong interpersonal skills and understand relationships are key to being successful
You are a leader. Teams love working with you, and you are someone who takes pride in mentoring and supporting the careers of others
You are a team player who is willing to roll‑up your sleeves and get the job done
Qualifications:
Advanced degree, postdoctoral training, or clinical residency in neurology, psychiatry, pharmacology or related biomedical sciences is required
MD or equivalent for the assessment of safety, tolerability, and adverse event profiles is preferred
Minimum 5 years’ experience in early phase pharmaceutical drug development
Proven track record of successfully advancing CNS assets from preclinical discovery through Phase I/II clinical development
Expertise in the application of neuroimaging modalities, translational biomarkers, and neurophysiological endpoints to support proof‑of‑concept studies
Deep understanding of pharmacokinetics, toxicology, and proof‑of‑mechanism trial design, with demonstrated ability to integrate these disciplines into clinical strategy
Regulatory experience, including the preparation and submission of INDs and NDAs
Ability to thrive in a fast‑paced, matrixed organization and drive programs forward within approved budgets and timelines
Highly motivated, self‑directed, and dependable, with a strong sense of ownership and urgency
Exceptional communication and interpersonal skills
Fluent in written and verbal business English
Committed to MapLight’s Core Beliefs and Values
Location:
This position is a hybrid 3 days per week in office either at our Redwood City, CA or Burlington, MA office.
Travel:
Ability to travel (approximately 25%)
MapLight is an equal opportunity employer, and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.
Compensation for this role may vary within the above range based on many factors including geographic location, candidate experience, and skills. Additional compensation/benefits include annual bonus opportunity, medical, dental, vision, life and AD&D, short term and long term disability, 401(K) plan with match, stock options, flexible non‑accrual paid time off, and parental leave.
Salary Range
$345,000 - $400,000 USD
Compensation for this role may vary within the above range based on many factors including geographic location, candidate experience, and skills. Additional compensation/benefits include annual bonus opportunity, medical, dental, vision, life and AD&D, short term and long term disability, 401(K) plan with match, stock options, flexible non‑accrual paid time off, and parental leave.
Salary Range
$345,000 - $400,000 USD
EEOC Statement: MapLight Therapeutics is an equal opportunity employer, and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.
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Who We Are:
MapLight Therapeutics is a clinical stage biotech company that focuses on drug discovery for central nervous system disorders. We combine cutting‑edge technologies including optogenetics, in vivo physiology, and spatial transcriptomics to identify novel drug targets and develop effective therapies to address psychiatric symptoms.
Key Responsibilities:
Lead, in partnership with Clinical Pharmacology, early clinical development plans and Phase 1 studies of CNS assets
Provide clear and insightful clinical and scientific expertise to advance the transition of compounds from discovery to full development
Align development plans and studies with corporate and departmental objectives
Design, execute, monitor, and interpret studies from concept to final report
Incorporate mechanistic insights and translational relevance into study designs, including the use of biomarkers and innovative designs
Ensure studies meet ethical, regulatory, and scientific standards and are delivered with the highest quality and within approved timelines and budget
Support regulatory submissions by preparing high‑quality contributions to INDs, NDAs, MAAs, and other regulatory documents
Represent the company at scientific meetings, advisory boards, and regulatory interactions
Publish and present clinical and translational findings to enhance the company’s scientific reputation
Support initiatives to foster a culture of scientific rigor, innovation, collegiality, and accountability across the development organization
Behaviors:
We consider these behaviors we seek in all MapLight employees
You participate and work effectively with multiple cross‑functional teams
You have strong interpersonal skills and understand relationships are key to being successful
You are a leader. Teams love working with you, and you are someone who takes pride in mentoring and supporting the careers of others
You are a team player who is willing to roll‑up your sleeves and get the job done
Qualifications:
Advanced degree, postdoctoral training, or clinical residency in neurology, psychiatry, pharmacology or related biomedical sciences is required
MD or equivalent for the assessment of safety, tolerability, and adverse event profiles is preferred
Minimum 5 years’ experience in early phase pharmaceutical drug development
Proven track record of successfully advancing CNS assets from preclinical discovery through Phase I/II clinical development
Expertise in the application of neuroimaging modalities, translational biomarkers, and neurophysiological endpoints to support proof‑of‑concept studies
Deep understanding of pharmacokinetics, toxicology, and proof‑of‑mechanism trial design, with demonstrated ability to integrate these disciplines into clinical strategy
Regulatory experience, including the preparation and submission of INDs and NDAs
Ability to thrive in a fast‑paced, matrixed organization and drive programs forward within approved budgets and timelines
Highly motivated, self‑directed, and dependable, with a strong sense of ownership and urgency
Exceptional communication and interpersonal skills
Fluent in written and verbal business English
Committed to MapLight’s Core Beliefs and Values
Location:
This position is a hybrid 3 days per week in office either at our Redwood City, CA or Burlington, MA office.
Travel:
Ability to travel (approximately 25%)
MapLight is an equal opportunity employer, and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.
Compensation for this role may vary within the above range based on many factors including geographic location, candidate experience, and skills. Additional compensation/benefits include annual bonus opportunity, medical, dental, vision, life and AD&D, short term and long term disability, 401(K) plan with match, stock options, flexible non‑accrual paid time off, and parental leave.
Salary Range
$345,000 - $400,000 USD
Compensation for this role may vary within the above range based on many factors including geographic location, candidate experience, and skills. Additional compensation/benefits include annual bonus opportunity, medical, dental, vision, life and AD&D, short term and long term disability, 401(K) plan with match, stock options, flexible non‑accrual paid time off, and parental leave.
Salary Range
$345,000 - $400,000 USD
EEOC Statement: MapLight Therapeutics is an equal opportunity employer, and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.
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