Eli Lilly and Company
Advisor/Sr. Advisor, Downstream Purification Development
Eli Lilly and Company, Indianapolis, Indiana, us, 46262
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees work to discover and bring life‑changing medicines, improve disease understanding and management, and give back through philanthropy and volunteerism. We put people first. We’re looking for people who are determined to make life better for people around the world.
Overview Bioproduct Research and Development (BRD) is the large‑molecule process development organization within Lilly. BRD is responsible for material and data generation to support clinical trials and commercialization of biologic therapeutics such as mAbs and bioconjugates. Our team works to accelerate the development and manufacturing of new bioconjugate medicines for our patients. We perform innovative research to deliver bioconjugation processes, knowledge, and best practices to support clinical trials and commercialization for antibody‑drug conjugates (ADCs), antibody‑peptide conjugates (APCs), and antibody‑RNA conjugates (ARCs/AOCs). We collaborate with Synthetic Molecule Design and Development (SMDD), discovery, and biologics development colleagues to advance this exciting class of new drugs and seek fundamental learning and platform approaches to their development.
Position Summary The scientist is responsible for leading teams of scientists and engineers in the development and optimization of purification processes for the production of recombinant therapeutic proteins. Additionally, the scientist leads or supports organizational strategic initiatives, evaluates and installs new capabilities and technologies, and leverages internal and external influence to solve problems and benchmark potential solutions.
Responsibilities
Lead the design, execution and interpretation of purification development experiments to define and optimize downstream processes for recombinant protein active pharmaceutical ingredients.
Apply first principles and designed experiments (DOE) to predict, understand, and control the impact of physical and chemical processing conditions on recombinant protein product quality.
Develop validated scaled‑down models of key bioprocess unit operations, including filtration/TFF, chromatography, and freeze/thaw.
Participate in and/or lead cross‑functional process development teams and collaborate with Bioprocess, Bioproduct Development, Discovery, Technical Services for Manufacturing, and Manufacturing groups.
Support transfer of purification processes to Technical Services for Manufacturing laboratories and pilot plant/manufacturing sites.
Authorship of technical reports and regulatory documents.
Work effectively with external parties on development projects, research collaborations, and outsourcing efforts.
Lead or support implementation of organizational strategic initiatives to support the Lilly pipeline.
Keep abreast of relevant scientific literature, new technologies, and regulatory initiatives; lead implementation as appropriate.
Leverage internal and external influence to solve problems and benchmark potential solutions.
Provide coaching, training, and performance management to personnel, primarily direct reports.
Ensure work and team activities align with all relevant Development Quality, regulatory, HSE, GLP, and GMP requirements.
Basic Requirements
Ph.D. in Biochemistry, Chemistry, or a related field.
General knowledge of scaling protein purification processes and use of statistics for data analysis.
Additional Preferences
Exceptional problem‑solving and decision‑making skills.
Demonstrated scientific and people leadership skills.
Effective oral and written communication skills.
Ability to work productively in an interdisciplinary team environment.
Physical Demands/Travel The physical demands of this job are consistent with a laboratory environment.
Work Environment This position’s work environment is a laboratory setting. The work environment characteristics described are representative of those an employee encounters while performing the essential functions of this job.
EEO Statement and Employee Resources Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.
Africa, Middle East, Central Asia Network
Black Employees at Lilly
Chinese Culture Network
Japanese International Leadership Network (JILN)
Lilly India Network
Organization of Latinx at Lilly (OLA)
PRIDE (LGBTQ+ Allies)
Veterans Leadership Network (VLN)
Women’s Initiative for Leading at Lilly (WILL)
enAble (for people with disabilities)
Compensation and Benefits Actual compensation will depend on education, experience, skills, and geographic location. The anticipated wage for this position is $126,000 - $204,600 per year.
Full‑time equivalent employees also are eligible for a company bonus and a comprehensive benefits program that includes a 401(k) plan, pension, vacation benefits, health, dental, vision, prescription drug coverage, flexible benefits, life insurance, disability benefits, paid time off, leave of absence, and well‑being resources such as employee assistance programs, fitness benefits, and employee clubs.
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Overview Bioproduct Research and Development (BRD) is the large‑molecule process development organization within Lilly. BRD is responsible for material and data generation to support clinical trials and commercialization of biologic therapeutics such as mAbs and bioconjugates. Our team works to accelerate the development and manufacturing of new bioconjugate medicines for our patients. We perform innovative research to deliver bioconjugation processes, knowledge, and best practices to support clinical trials and commercialization for antibody‑drug conjugates (ADCs), antibody‑peptide conjugates (APCs), and antibody‑RNA conjugates (ARCs/AOCs). We collaborate with Synthetic Molecule Design and Development (SMDD), discovery, and biologics development colleagues to advance this exciting class of new drugs and seek fundamental learning and platform approaches to their development.
Position Summary The scientist is responsible for leading teams of scientists and engineers in the development and optimization of purification processes for the production of recombinant therapeutic proteins. Additionally, the scientist leads or supports organizational strategic initiatives, evaluates and installs new capabilities and technologies, and leverages internal and external influence to solve problems and benchmark potential solutions.
Responsibilities
Lead the design, execution and interpretation of purification development experiments to define and optimize downstream processes for recombinant protein active pharmaceutical ingredients.
Apply first principles and designed experiments (DOE) to predict, understand, and control the impact of physical and chemical processing conditions on recombinant protein product quality.
Develop validated scaled‑down models of key bioprocess unit operations, including filtration/TFF, chromatography, and freeze/thaw.
Participate in and/or lead cross‑functional process development teams and collaborate with Bioprocess, Bioproduct Development, Discovery, Technical Services for Manufacturing, and Manufacturing groups.
Support transfer of purification processes to Technical Services for Manufacturing laboratories and pilot plant/manufacturing sites.
Authorship of technical reports and regulatory documents.
Work effectively with external parties on development projects, research collaborations, and outsourcing efforts.
Lead or support implementation of organizational strategic initiatives to support the Lilly pipeline.
Keep abreast of relevant scientific literature, new technologies, and regulatory initiatives; lead implementation as appropriate.
Leverage internal and external influence to solve problems and benchmark potential solutions.
Provide coaching, training, and performance management to personnel, primarily direct reports.
Ensure work and team activities align with all relevant Development Quality, regulatory, HSE, GLP, and GMP requirements.
Basic Requirements
Ph.D. in Biochemistry, Chemistry, or a related field.
General knowledge of scaling protein purification processes and use of statistics for data analysis.
Additional Preferences
Exceptional problem‑solving and decision‑making skills.
Demonstrated scientific and people leadership skills.
Effective oral and written communication skills.
Ability to work productively in an interdisciplinary team environment.
Physical Demands/Travel The physical demands of this job are consistent with a laboratory environment.
Work Environment This position’s work environment is a laboratory setting. The work environment characteristics described are representative of those an employee encounters while performing the essential functions of this job.
EEO Statement and Employee Resources Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.
Africa, Middle East, Central Asia Network
Black Employees at Lilly
Chinese Culture Network
Japanese International Leadership Network (JILN)
Lilly India Network
Organization of Latinx at Lilly (OLA)
PRIDE (LGBTQ+ Allies)
Veterans Leadership Network (VLN)
Women’s Initiative for Leading at Lilly (WILL)
enAble (for people with disabilities)
Compensation and Benefits Actual compensation will depend on education, experience, skills, and geographic location. The anticipated wage for this position is $126,000 - $204,600 per year.
Full‑time equivalent employees also are eligible for a company bonus and a comprehensive benefits program that includes a 401(k) plan, pension, vacation benefits, health, dental, vision, prescription drug coverage, flexible benefits, life insurance, disability benefits, paid time off, leave of absence, and well‑being resources such as employee assistance programs, fitness benefits, and employee clubs.
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