XtalPi Inc.
Chief Scientific Officer of Small Molecule Business
XtalPi Inc., Boston, Massachusetts, us, 02298
Overview
Chief Scientific Officer of Small Molecule Business Experience:
15+ years in drug discovery R&D Role Summary: We’re looking for someone with extensive experience in drug R&D—ideally from a large pharma environment—who can provide scientific vision, operational discipline, and BD-savvy leadership. Key Responsibilities End-to-End Leadership: Define and execute the comprehensive scientific strategy for small molecule research, covering Discovery, Target Identification, Lead Optimization, and Translational platforms. Portfolio Management: Oversee the progression of internal and partnered assets. Make critical data-driven decisions on candidate progression, prioritization, and portfolio diversification to maximize clinical success probability. Innovation: Stay at the forefront of global trends in small molecule research and AI-enabled drug discovery, ensuring XtalPi remains a competitive leader in the industry. Team Empowerment: Lead, mentor, and inspire a diverse team of scientists across Molecular Chemistry, Biology, Discovery, and Engineering. Cross-Functional Collaboration: Partner closely with internal AI and algorithm teams. You do not need to be a coder, but you must be a champion for digital transformation. Workflow Optimization: Co-develop practical, problem-driven technologies. Provide the "chemist’s perspective" to ensure AI tools effectively enhance experimental workflows and accelerate decision-making cycles. External Engagement: Serve as the senior scientific voice of XtalPi in external engagements. Represent the company at major scientific conferences, investor meetings, and industry forums. Strategic Partnerships: Act as a key scientific counterpart to our Pharma and Biotech partners, driving collaboration success and identifying new business opportunities through scientific excellence. Qualifications Ph.D. in Medicinal Chemistry, Pharmacology, Organic Chemistry, or a related small molecule discipline. 15+ years of progressive experience in drug discovery and development, with a significant tenure in leadership roles within large pharmaceutical companies or global biotech organizations. Track Record: Proven history of successfully leading large scientific teams and delivering candidates from discovery into clinical development. Executive Presence: Exceptional communication and presentation skills. Ability to articulate complex scientific concepts to diverse audiences, including investors, partners, and non-scientific stakeholders. Tech-Forward Mindset: Comfortable working at the intersection of science and technology. While prior computational experience is not required, a strong willingness to collaborate with AI teams and adopt new methodologies is essential. Strategic Thinking: Demonstrated ability to balance scientific curiosity with business acumen and portfolio strategy. Seniority level : Executive Employment type : Full-time Job function : Science
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Chief Scientific Officer of Small Molecule Business Experience:
15+ years in drug discovery R&D Role Summary: We’re looking for someone with extensive experience in drug R&D—ideally from a large pharma environment—who can provide scientific vision, operational discipline, and BD-savvy leadership. Key Responsibilities End-to-End Leadership: Define and execute the comprehensive scientific strategy for small molecule research, covering Discovery, Target Identification, Lead Optimization, and Translational platforms. Portfolio Management: Oversee the progression of internal and partnered assets. Make critical data-driven decisions on candidate progression, prioritization, and portfolio diversification to maximize clinical success probability. Innovation: Stay at the forefront of global trends in small molecule research and AI-enabled drug discovery, ensuring XtalPi remains a competitive leader in the industry. Team Empowerment: Lead, mentor, and inspire a diverse team of scientists across Molecular Chemistry, Biology, Discovery, and Engineering. Cross-Functional Collaboration: Partner closely with internal AI and algorithm teams. You do not need to be a coder, but you must be a champion for digital transformation. Workflow Optimization: Co-develop practical, problem-driven technologies. Provide the "chemist’s perspective" to ensure AI tools effectively enhance experimental workflows and accelerate decision-making cycles. External Engagement: Serve as the senior scientific voice of XtalPi in external engagements. Represent the company at major scientific conferences, investor meetings, and industry forums. Strategic Partnerships: Act as a key scientific counterpart to our Pharma and Biotech partners, driving collaboration success and identifying new business opportunities through scientific excellence. Qualifications Ph.D. in Medicinal Chemistry, Pharmacology, Organic Chemistry, or a related small molecule discipline. 15+ years of progressive experience in drug discovery and development, with a significant tenure in leadership roles within large pharmaceutical companies or global biotech organizations. Track Record: Proven history of successfully leading large scientific teams and delivering candidates from discovery into clinical development. Executive Presence: Exceptional communication and presentation skills. Ability to articulate complex scientific concepts to diverse audiences, including investors, partners, and non-scientific stakeholders. Tech-Forward Mindset: Comfortable working at the intersection of science and technology. While prior computational experience is not required, a strong willingness to collaborate with AI teams and adopt new methodologies is essential. Strategic Thinking: Demonstrated ability to balance scientific curiosity with business acumen and portfolio strategy. Seniority level : Executive Employment type : Full-time Job function : Science
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