National Guard Employment Network
Associate Scientist, Product Sciences - Seattle, WA
National Guard Employment Network, Seattle, Washington, United States, 98101
Associate Scientist, Product Sciences - Seattle, WA
Attention Military Affiliated Job Seekers - Our organization works with partner companies to source qualified talent for their open roles. The following position is available to Veterans, Transitioning Military, National Guard and Reserve Members, Military Spouses, Wounded Warriors, and their Caregivers. If you have the required skill set, education requirements, and experience, please follow the next steps. This role is "On-Site" at the location detailed in the job post. Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible. Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services, and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Position Summary
The primary focus of the Associate Scientist role will be lab-based activities (i.e., building analytical and/or process capabilities) to build T cell product and process understanding in support of CAR T products with a particular focus on investigational needs in support of middle/late-stage clinical CMC development, process automation, manufacturing success, and robust product/process control strategies. Successful candidates will have a very strong foundation in cell-based assays (flow cytometry, proliferation, cytotoxicity, cytokine release, etc.) and some background in human T cell biology and/or other immune cell types. Experience with implementation and optimization of a broad range of in vitro cell-based and molecular assays is critical (especially multi-color flow cytometry and cell culture). This role is highly collaborative and requires attention to detail, a healthy sense of urgency, a strong desire to learn, and a passion for exploratory and investigational science. Furthermore, a demonstrated ability to support cross-functional teams and independently design and execute studies to meet project goals is desirable (albeit not a requirement and will depend on the applicant's individual qualifications). Key Responsibilities
The primary focus of this role is to support middle/late-stage and/or commercial drug product and manufacturing process understanding by performing characterization studies and investigational analyses including experimental design and execution, statistical/correlative analyses of existing data sets, writing technical reports, presenting data, etc. Additionally, depending on the applicant's individual qualifications, duties and responsibilities include the following: Execute characterization of T cell and/or other immune cells using flow cytometry, genome-wide expression analysis, metabolic profiling, and/or additional cutting-edge analytical techniques, as necessary to support manufacturing and Scientific CMC strategies. Analyze, interpret, and report experimental results to support conclusions and next steps. Optimize and execute assays, manage instruments and reagents, monitor assay performance, and troubleshoot. Serve as analytical method SME. Develop and maintain relationships with external collaborators and service providers. Author, review, and approve technical documents, including methods, protocols, reports, and SOPs. Serve as T cell biology subject matter expert in multidisciplinary team setting, that includes non-clinical, clinical, regulatory, and CMC functions; and participate in cross-functional teams to support the advancement and manufacture of gene engineered T cell therapeutic platforms. Qualifications & Experience Required
Extensive experience with standard and next generation analytical platforms for the characterization of T cell phenotype, differentiation, and function [Multi-color Flow Cytometry (BD Symphony, BD A5); Spectral Flow Cytometry (Cytek Aurora); Proliferation (CellTrace, Incucyte); Cytotoxicity (Calcein, LDH, Incucyte); Cytokine Release (Luminex, MSD, Intracellular Staining)] and process/enrichment platforms (e.g., CliniMACs, TYTO, RoboSep, EasySep). Experience with data visualization and analysis software (JMP, EXCEL, etc.) and/or coding-based analysis (R, Python, etc.). Proven ability to collaborate in a fast-paced environment, meet deadlines, and prioritize work on multiple projects. Attention to detail and excellent interpersonal, written, and verbal communication skills. Preferred Qualifications
Demonstrated independence in experimental design, data analysis, interpretation, and presentation. Demonstrated experience with CAR-T products and scale-down models for CAR-T cell processing and production. Expertise in human T cell biology and in vitro characterization of T cell differentiation and function. Salary Range
The starting compensation for this job is a range from $82,000 - $102,000, plus incentive cash and stock opportunities (based on eligibility). The starting pay rate takes into account characteristics of the job, such as required skills and the geographic location where work is performed. Final, individual compensation is decided commensurate with demonstrated experience.
Attention Military Affiliated Job Seekers - Our organization works with partner companies to source qualified talent for their open roles. The following position is available to Veterans, Transitioning Military, National Guard and Reserve Members, Military Spouses, Wounded Warriors, and their Caregivers. If you have the required skill set, education requirements, and experience, please follow the next steps. This role is "On-Site" at the location detailed in the job post. Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible. Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services, and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Position Summary
The primary focus of the Associate Scientist role will be lab-based activities (i.e., building analytical and/or process capabilities) to build T cell product and process understanding in support of CAR T products with a particular focus on investigational needs in support of middle/late-stage clinical CMC development, process automation, manufacturing success, and robust product/process control strategies. Successful candidates will have a very strong foundation in cell-based assays (flow cytometry, proliferation, cytotoxicity, cytokine release, etc.) and some background in human T cell biology and/or other immune cell types. Experience with implementation and optimization of a broad range of in vitro cell-based and molecular assays is critical (especially multi-color flow cytometry and cell culture). This role is highly collaborative and requires attention to detail, a healthy sense of urgency, a strong desire to learn, and a passion for exploratory and investigational science. Furthermore, a demonstrated ability to support cross-functional teams and independently design and execute studies to meet project goals is desirable (albeit not a requirement and will depend on the applicant's individual qualifications). Key Responsibilities
The primary focus of this role is to support middle/late-stage and/or commercial drug product and manufacturing process understanding by performing characterization studies and investigational analyses including experimental design and execution, statistical/correlative analyses of existing data sets, writing technical reports, presenting data, etc. Additionally, depending on the applicant's individual qualifications, duties and responsibilities include the following: Execute characterization of T cell and/or other immune cells using flow cytometry, genome-wide expression analysis, metabolic profiling, and/or additional cutting-edge analytical techniques, as necessary to support manufacturing and Scientific CMC strategies. Analyze, interpret, and report experimental results to support conclusions and next steps. Optimize and execute assays, manage instruments and reagents, monitor assay performance, and troubleshoot. Serve as analytical method SME. Develop and maintain relationships with external collaborators and service providers. Author, review, and approve technical documents, including methods, protocols, reports, and SOPs. Serve as T cell biology subject matter expert in multidisciplinary team setting, that includes non-clinical, clinical, regulatory, and CMC functions; and participate in cross-functional teams to support the advancement and manufacture of gene engineered T cell therapeutic platforms. Qualifications & Experience Required
Extensive experience with standard and next generation analytical platforms for the characterization of T cell phenotype, differentiation, and function [Multi-color Flow Cytometry (BD Symphony, BD A5); Spectral Flow Cytometry (Cytek Aurora); Proliferation (CellTrace, Incucyte); Cytotoxicity (Calcein, LDH, Incucyte); Cytokine Release (Luminex, MSD, Intracellular Staining)] and process/enrichment platforms (e.g., CliniMACs, TYTO, RoboSep, EasySep). Experience with data visualization and analysis software (JMP, EXCEL, etc.) and/or coding-based analysis (R, Python, etc.). Proven ability to collaborate in a fast-paced environment, meet deadlines, and prioritize work on multiple projects. Attention to detail and excellent interpersonal, written, and verbal communication skills. Preferred Qualifications
Demonstrated independence in experimental design, data analysis, interpretation, and presentation. Demonstrated experience with CAR-T products and scale-down models for CAR-T cell processing and production. Expertise in human T cell biology and in vitro characterization of T cell differentiation and function. Salary Range
The starting compensation for this job is a range from $82,000 - $102,000, plus incentive cash and stock opportunities (based on eligibility). The starting pay rate takes into account characteristics of the job, such as required skills and the geographic location where work is performed. Final, individual compensation is decided commensurate with demonstrated experience.