Mount Sinai Health System
Title:
Postdoctoral Fellow TR05 (partially ISMMS funded) Salary:
$74,692 total ($36,000 external funding) Department:
Medicine/Nephrology Location:
1468 Madison Avenue, Annenberg 23-16, New York, NY 10029 Principal Investigator:
John Cijiang He Lab Web:
https://labs.icahn.mssm.edu/helab/meet-the-team/ Department Web:
https://icahn.mssm.edu/about/departments/medicine/nephrology Project Overview
Diabetic kidney disease is the number one cause of kidney failure in the USA and worldwide. Its pathogenesis remains unclear and treatment options are limited. Using a systems biology approach, the project seeks to identify new drug targets, focusing on LRG1’s role in renal endothelial and tubular cell injury. In vitro assays and in vivo animal models will confirm the critical role of LRG1 in kidney cell injury. Technical Duties
Perform in vitro cell cultures of glomerular endothelial cells, tubular endothelial cells, and tubular epithelial cells and test whether overexpression or knockdown of LRG1 affects cell function and downstream signaling pathways. Use transgenic mouse models with overexpression or knockdown of LRG1 in endothelial cells and tubular cells to assess kidney injury development. Apply techniques including cell culture, western blot, qPCR, mouse genotyping, mouse breeding, kidney histology analysis, immunostaining, determination of urine albumin and renal function. Qualifications
Postdoctoral level with medical training (MD equivalent) or basic science training and familiarity with kidney disease pathogenesis. Basic training in medical research with benchwork and animal studies experience. Employer Description
The Mount Sinai Health System is committed to fostering an environment where everyone can contribute to excellence. We share a common dedication to delivering outstanding patient care and are dedicated to building a supportive and welcoming environment. Equal Opportunity Employer
The Mount Sinai Health System is an equal‑opportunity employer, complying with all applicable federal civil rights laws. We do not discriminate on the basis of race, color, national origin, age, religion, disability, sex, sexual orientation, gender, veteran status, or any other characteristic protected by law. Compensation
The salary range for this role is $72,500 – $80,000 annually, depending on experience, education, and operational need. The range does not include bonuses, incentives, or other forms of compensation.
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Postdoctoral Fellow TR05 (partially ISMMS funded) Salary:
$74,692 total ($36,000 external funding) Department:
Medicine/Nephrology Location:
1468 Madison Avenue, Annenberg 23-16, New York, NY 10029 Principal Investigator:
John Cijiang He Lab Web:
https://labs.icahn.mssm.edu/helab/meet-the-team/ Department Web:
https://icahn.mssm.edu/about/departments/medicine/nephrology Project Overview
Diabetic kidney disease is the number one cause of kidney failure in the USA and worldwide. Its pathogenesis remains unclear and treatment options are limited. Using a systems biology approach, the project seeks to identify new drug targets, focusing on LRG1’s role in renal endothelial and tubular cell injury. In vitro assays and in vivo animal models will confirm the critical role of LRG1 in kidney cell injury. Technical Duties
Perform in vitro cell cultures of glomerular endothelial cells, tubular endothelial cells, and tubular epithelial cells and test whether overexpression or knockdown of LRG1 affects cell function and downstream signaling pathways. Use transgenic mouse models with overexpression or knockdown of LRG1 in endothelial cells and tubular cells to assess kidney injury development. Apply techniques including cell culture, western blot, qPCR, mouse genotyping, mouse breeding, kidney histology analysis, immunostaining, determination of urine albumin and renal function. Qualifications
Postdoctoral level with medical training (MD equivalent) or basic science training and familiarity with kidney disease pathogenesis. Basic training in medical research with benchwork and animal studies experience. Employer Description
The Mount Sinai Health System is committed to fostering an environment where everyone can contribute to excellence. We share a common dedication to delivering outstanding patient care and are dedicated to building a supportive and welcoming environment. Equal Opportunity Employer
The Mount Sinai Health System is an equal‑opportunity employer, complying with all applicable federal civil rights laws. We do not discriminate on the basis of race, color, national origin, age, religion, disability, sex, sexual orientation, gender, veteran status, or any other characteristic protected by law. Compensation
The salary range for this role is $72,500 – $80,000 annually, depending on experience, education, and operational need. The range does not include bonuses, incentives, or other forms of compensation.
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