Bristol Myers Squibb
Senior Scientist, Discovery BioSciences Oncology
Bristol Myers Squibb, Cambridge, Massachusetts, us, 02140
R1598206 : Senior Scientist, Discovery BioSciences Oncology
Company:
Bristol-Myers Squibb
Req Number:
R1598206
Location:
Cambridge Crossing-MA
Position Overview We are seeking a highly motivated, experienced and talented Senior Scientist to join our Discovery Biosciences team. This individual will play a key role in advancing our oncology drug discovery programs, with a focus on cancer immunology and next-generation biotherapeutic target identification, validation, mechanism of action and optimization studies.
Position Responsibilities
Conduct full time laboratory-based research supporting target identification, oncology drug discovery and development
Strong biology skills with experience using a wide range of cellular and molecular biology techniques, 2D and 3D cell culture and manipulation of complex cellular model systems (organoid, immune and stromal cell co-culture, and cancer cells), flow cytometry, qPCR, cell proliferation assays, generating reporter assays, molecular cloning, western blotting, immunoprecipitation, ELISA, and MSD
Experience with in vivo oncology and/or immunology models. Animal handling is not a requirement, but the candidate should understand the strengths and weaknesses of commonly used cancer immunology models, and have experience with downstream tissue processing (dissociation, flow cytometry, IHC)
Strong experience developing and applying state-of-the-art gene perturbation methods (siRNA/shRNA knockdown, nucleofection, and CRISPR-mediated genome editing)
Design, optimize, and troubleshoot complex cell-based and in vivo assays to evaluate therapeutic candidates and understand cancer signaling pathways
Collaborate with cross-functional teams, including medicinal chemistry, bioinformatics, and in vivo pharmacology, to advance project goals
Analyze and interpret experimental data, maintain accurate and detailed lab records, and present findings in team meetings
Contribute to the preparation of technical reports, publications, and presentations
Basic Qualifications
Bachelor's Degree
7+ years of academic and / or industry experience
Or
Master's Degree
5+ years of academic and / or industry experience
Or
Ph.D. or equivalent advanced degree in the Life Sciences
2+ years of academic and / or industry experience
Preferred Qualifications
PhD and 2+ years of academic and / or industry experience preferred
Extensive experience in oncology research, with background in cancer immunology and/or biotherapeutics (e.g. ADCs, multi-specifics, and TCEs) is strongly preferred
Proven track record with designing and developing a variety of molecular biology and cellular assays
Hands on experience with functional genomics, CRISPR screens, high content imaging, flow cytometry, RNA-seq and proteomics is highly desirable
Proficiency in data analysis software (e.g., GraphPad Prism, FlowJo) and familiarity with bioinformatics tools
Familiarity with querying large-scale oncology datasets (DepMap, cBioPortal, TCGA) to generate and test hypotheses
Effective troubleshooting skills when optimizing assays and when developing innovative methodologies
Compensation Overview Cambridge Crossing: $137,570 - $166,706
The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. Final, individual compensation will be decided based on demonstrated experience.
Benefit Offerings
Health Coverage:
Medical, pharmacy, dental, and vision care.
Wellbeing Support:
Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
Financial Well-being and Protection:
401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.
#LI-Onsite
If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway.
Equal Opportunity Bristol Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, pregnancy, citizenship, marital status, gender expression, genetic information, political affiliation, or any other characteristic protected by law.
Updated 2026-01-13 03:36:56.914 UTC
Provided by BMS Recruitment Team
#J-18808-Ljbffr
Company:
Bristol-Myers Squibb
Req Number:
R1598206
Location:
Cambridge Crossing-MA
Position Overview We are seeking a highly motivated, experienced and talented Senior Scientist to join our Discovery Biosciences team. This individual will play a key role in advancing our oncology drug discovery programs, with a focus on cancer immunology and next-generation biotherapeutic target identification, validation, mechanism of action and optimization studies.
Position Responsibilities
Conduct full time laboratory-based research supporting target identification, oncology drug discovery and development
Strong biology skills with experience using a wide range of cellular and molecular biology techniques, 2D and 3D cell culture and manipulation of complex cellular model systems (organoid, immune and stromal cell co-culture, and cancer cells), flow cytometry, qPCR, cell proliferation assays, generating reporter assays, molecular cloning, western blotting, immunoprecipitation, ELISA, and MSD
Experience with in vivo oncology and/or immunology models. Animal handling is not a requirement, but the candidate should understand the strengths and weaknesses of commonly used cancer immunology models, and have experience with downstream tissue processing (dissociation, flow cytometry, IHC)
Strong experience developing and applying state-of-the-art gene perturbation methods (siRNA/shRNA knockdown, nucleofection, and CRISPR-mediated genome editing)
Design, optimize, and troubleshoot complex cell-based and in vivo assays to evaluate therapeutic candidates and understand cancer signaling pathways
Collaborate with cross-functional teams, including medicinal chemistry, bioinformatics, and in vivo pharmacology, to advance project goals
Analyze and interpret experimental data, maintain accurate and detailed lab records, and present findings in team meetings
Contribute to the preparation of technical reports, publications, and presentations
Basic Qualifications
Bachelor's Degree
7+ years of academic and / or industry experience
Or
Master's Degree
5+ years of academic and / or industry experience
Or
Ph.D. or equivalent advanced degree in the Life Sciences
2+ years of academic and / or industry experience
Preferred Qualifications
PhD and 2+ years of academic and / or industry experience preferred
Extensive experience in oncology research, with background in cancer immunology and/or biotherapeutics (e.g. ADCs, multi-specifics, and TCEs) is strongly preferred
Proven track record with designing and developing a variety of molecular biology and cellular assays
Hands on experience with functional genomics, CRISPR screens, high content imaging, flow cytometry, RNA-seq and proteomics is highly desirable
Proficiency in data analysis software (e.g., GraphPad Prism, FlowJo) and familiarity with bioinformatics tools
Familiarity with querying large-scale oncology datasets (DepMap, cBioPortal, TCGA) to generate and test hypotheses
Effective troubleshooting skills when optimizing assays and when developing innovative methodologies
Compensation Overview Cambridge Crossing: $137,570 - $166,706
The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. Final, individual compensation will be decided based on demonstrated experience.
Benefit Offerings
Health Coverage:
Medical, pharmacy, dental, and vision care.
Wellbeing Support:
Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
Financial Well-being and Protection:
401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.
#LI-Onsite
If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway.
Equal Opportunity Bristol Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, pregnancy, citizenship, marital status, gender expression, genetic information, political affiliation, or any other characteristic protected by law.
Updated 2026-01-13 03:36:56.914 UTC
Provided by BMS Recruitment Team
#J-18808-Ljbffr