University Hospitals
Job Description - Research Scientist Genetics (2600005S)
A Brief Overview
The research scientist will be primarily responsible for conducting cellular, molecular, in vivo animal studies, data processing, scientific interpretation, manuscript preparation, and grant applications that can be achieved by teamwork with colleagues and project manager/principal investigator. Working under the appropriate guidance of a project manager, the research scientist will coordinate projects involving the development of novel therapeutics for malignant cancers (e.g., targeting senescence or stem cell‑mediated drug resistance in pediatric glioblastoma and sarcomas). The research scientist will also be engaged in the project of cancer vaccine study in controlling immune‑resistance of cancers, especially by using syngeneic or humanized mouse models of pediatric brain tumors, sarcomas, and malignant adolescence and young adult (AYA) cancers.
What You Will Do
Coordinate research projects involving development of novel therapeutic agents and immune‑mediated anti‑cancer studies by using mouse models of pediatric cancers and malignant AYA cancers. Maintain schedules for staff, ensuring compliance with protocol guidelines and requirements of regulatory agencies; identify problems and/or inconsistencies and recommend corrective action as appropriate. Prepare animal protocol updates and scientific manuscripts. (60%)
Provide input and recommendations to principal investigator regarding significant developments in research projects and write a grant proposal under the guidance of project manager. (7%)
Perform the most complex quantitative analytical procedures on data obtained from the research assistant’s studies which include gene arrays and similar data sets. (4%)
Conduct studies in cancer biology and key cellular signaling. Techniques include mouse and human tumor cell culture in vitro and in vivo PDX models, primary cell culture, flow cytometry, gene or CRISPR/Cas9 gRNA transfection, signaling mechanisms, flow cytometry, Westerns, co‑IPs, qPCR assays, ELISAs, ELISPOT, primer design, ChIPs, in vivo studies in mice (tumor, bone marrow, lymph node and spleen isolation), cancer vaccine immunization, analyses of patients tumor and TIL cells. (15%)
Devise new protocols and techniques for research projects involving a high degree of skill and training. Evaluate adequacy of techniques and study new procedures and data analyses. Voluntarily cooperate with others as needed. (5%)
Present work at weekly lab meetings and critique presentations by others and students. (5%)
May supervise Research Assistants and Technicians. Teach or instruct others in research techniques. (3%)
Perform other laboratory duties as assigned. ( Additional Responsibilities
Performs other duties as assigned.
Complies with all policies and standards.
For specific duties and responsibilities, refer to documentation provided by the department during orientation.
Must abide by all requirements to safely and securely maintain Protected Health Information (PHI) for our patients. Annual training, the UH Code of Conduct and UH policies and procedures are in place to address appropriate use of PHI in the workplace.
Education
Doctorate Degree in science (Required)
Work Experience
5+ years related experience (Required)
Previous experience working with animals (Preferred)
Previous experience in glioblastoma senescence (Preferred)
Knowledge, Skills, & Abilities
Has knowledge of commonly‑used concepts, practices, and procedures within a particular field. (Required proficiency)
Relies on instructions and pre‑established guidelines to perform the functions of the job. (Required proficiency)
Ability to operate laboratory equipment. (Required proficiency)
Ability to meet consistent attendance. (Required proficiency)
Ability to interact with colleagues, supervisors, and customers face to face. (Required proficiency)
Strong molecular biology skills (PCR, Western blots, Retroviral/Lentiviral constructs). (Required proficiency)
Strong organization skills and good habit of maintaining a clean lab working environment; demonstrate attention to detail and accuracy, time management skills, and proven ability to successfully follow‑through on assigned projects. (Required proficiency)
Professional and effective verbal and written communication skills and good interpersonal skills with the ability to work and communicate with various individuals within and external to the University. (Required proficiency)
Ability to work effectively independently and collaboratively within a team (must be highly motivated, responsible, dependable and a self‑starter). (Required proficiency)
Ability to work with sensitive information and maintain confidentiality. (Required proficiency)
Proficiency in Microsoft Office and GraphPad Prism. Experience using Adobe Photoshop, Illustrator, and FlowJo. (Preferred proficiency)
Ability to maintain meticulous, complete, and easily retrievable laboratory data. (Required proficiency)
Ability to willingly learn new techniques and procedures as needed, follow established protocols or laboratory procedures and request clarification if necessary. (Required proficiency)
Must demonstrate compliance with university animal research and care (ARC) policies and procedures and compliance to regulations of the Animal Welfare Act, Public Health Service Policy, AAALAC guidelines and other applicable regulatory guidelines. (Required proficiency)
Must demonstrate compassion for animals within university facilities and dedication to the Animal Resource Center’s mission. Must handle animals with care and respect at all times. (Required proficiency)
Able and willing to learn new techniques, procedures, processes, and computer gear to protect the health of the animals. (Required proficiency)
Physical Demands
Standing Frequently
Walking Frequently
Sitting Rarely
Lifting Frequently up to 50 lbs
Carrying Frequently up to 50 lbs
Pushing Frequently up to 50 lbs
Pulling Frequently up to 50 lbs
Climbing Occasionally up to 50 lbs
Balancing Occasionally
Stooping Frequently
Kneeling Frequently
Crouching Frequently
Crawling Occasionally
Reaching Frequently
Handling Frequently
Grasping Frequently
Feeling Constantly
Talking Constantly
Hearing Constantly
Repetitive Motions Constantly
Eye/Hand/Foot Coordination Constantly
Travel Requirements
10%
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What You Will Do
Coordinate research projects involving development of novel therapeutic agents and immune‑mediated anti‑cancer studies by using mouse models of pediatric cancers and malignant AYA cancers. Maintain schedules for staff, ensuring compliance with protocol guidelines and requirements of regulatory agencies; identify problems and/or inconsistencies and recommend corrective action as appropriate. Prepare animal protocol updates and scientific manuscripts. (60%)
Provide input and recommendations to principal investigator regarding significant developments in research projects and write a grant proposal under the guidance of project manager. (7%)
Perform the most complex quantitative analytical procedures on data obtained from the research assistant’s studies which include gene arrays and similar data sets. (4%)
Conduct studies in cancer biology and key cellular signaling. Techniques include mouse and human tumor cell culture in vitro and in vivo PDX models, primary cell culture, flow cytometry, gene or CRISPR/Cas9 gRNA transfection, signaling mechanisms, flow cytometry, Westerns, co‑IPs, qPCR assays, ELISAs, ELISPOT, primer design, ChIPs, in vivo studies in mice (tumor, bone marrow, lymph node and spleen isolation), cancer vaccine immunization, analyses of patients tumor and TIL cells. (15%)
Devise new protocols and techniques for research projects involving a high degree of skill and training. Evaluate adequacy of techniques and study new procedures and data analyses. Voluntarily cooperate with others as needed. (5%)
Present work at weekly lab meetings and critique presentations by others and students. (5%)
May supervise Research Assistants and Technicians. Teach or instruct others in research techniques. (3%)
Perform other laboratory duties as assigned. ( Additional Responsibilities
Performs other duties as assigned.
Complies with all policies and standards.
For specific duties and responsibilities, refer to documentation provided by the department during orientation.
Must abide by all requirements to safely and securely maintain Protected Health Information (PHI) for our patients. Annual training, the UH Code of Conduct and UH policies and procedures are in place to address appropriate use of PHI in the workplace.
Education
Doctorate Degree in science (Required)
Work Experience
5+ years related experience (Required)
Previous experience working with animals (Preferred)
Previous experience in glioblastoma senescence (Preferred)
Knowledge, Skills, & Abilities
Has knowledge of commonly‑used concepts, practices, and procedures within a particular field. (Required proficiency)
Relies on instructions and pre‑established guidelines to perform the functions of the job. (Required proficiency)
Ability to operate laboratory equipment. (Required proficiency)
Ability to meet consistent attendance. (Required proficiency)
Ability to interact with colleagues, supervisors, and customers face to face. (Required proficiency)
Strong molecular biology skills (PCR, Western blots, Retroviral/Lentiviral constructs). (Required proficiency)
Strong organization skills and good habit of maintaining a clean lab working environment; demonstrate attention to detail and accuracy, time management skills, and proven ability to successfully follow‑through on assigned projects. (Required proficiency)
Professional and effective verbal and written communication skills and good interpersonal skills with the ability to work and communicate with various individuals within and external to the University. (Required proficiency)
Ability to work effectively independently and collaboratively within a team (must be highly motivated, responsible, dependable and a self‑starter). (Required proficiency)
Ability to work with sensitive information and maintain confidentiality. (Required proficiency)
Proficiency in Microsoft Office and GraphPad Prism. Experience using Adobe Photoshop, Illustrator, and FlowJo. (Preferred proficiency)
Ability to maintain meticulous, complete, and easily retrievable laboratory data. (Required proficiency)
Ability to willingly learn new techniques and procedures as needed, follow established protocols or laboratory procedures and request clarification if necessary. (Required proficiency)
Must demonstrate compliance with university animal research and care (ARC) policies and procedures and compliance to regulations of the Animal Welfare Act, Public Health Service Policy, AAALAC guidelines and other applicable regulatory guidelines. (Required proficiency)
Must demonstrate compassion for animals within university facilities and dedication to the Animal Resource Center’s mission. Must handle animals with care and respect at all times. (Required proficiency)
Able and willing to learn new techniques, procedures, processes, and computer gear to protect the health of the animals. (Required proficiency)
Physical Demands
Standing Frequently
Walking Frequently
Sitting Rarely
Lifting Frequently up to 50 lbs
Carrying Frequently up to 50 lbs
Pushing Frequently up to 50 lbs
Pulling Frequently up to 50 lbs
Climbing Occasionally up to 50 lbs
Balancing Occasionally
Stooping Frequently
Kneeling Frequently
Crouching Frequently
Crawling Occasionally
Reaching Frequently
Handling Frequently
Grasping Frequently
Feeling Constantly
Talking Constantly
Hearing Constantly
Repetitive Motions Constantly
Eye/Hand/Foot Coordination Constantly
Travel Requirements
10%
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