Senior Director, Antibody Discovery and Engineering
Calico Life Sciences, South San Francisco
Senior Director, Antibody Discovery and Engineering
Join to apply for the Senior Director, Antibody Discovery and Engineering role at Calico Life Sciences
Senior Director, Antibody Discovery and Engineering
Join to apply for the Senior Director, Antibody Discovery and Engineering role at Calico Life Sciences
Get AI-powered advice on this job and more exclusive features.
Who We Are
Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.
Who We Are
Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.
Position Description
We are seeking a highly experienced individual for a position as Senior Director of Antibody Discovery and Engineering. This position will head a small team of scientists and oversee CROs responsible for designing, generating, and characterizing antibody-based therapeutics, including multispecifics and other advanced modalities. The position will report to the Head of Discovery Technologies and work closely with scientists and leaders in Computational Sciences, Protein Sciences, Assay Development groups, and interact with project teams. The position requires the candidate to have extensive experience in antibody discovery, engineering, characterization, rational design/combinatorial approaches, and computational engineering. The candidate is expected to drive innovative antibody technologies that advance therapeutic pipelines and be a thought leader in developing novel approaches for the de novo design and optimization of antibody therapeutics. The candidate may lead programs from lead to pre-IND, integrating early research and progressing through candidate nomination.
Position Requirements
- Ph.D. in molecular biology, biochemistry, or related discipline, plus >15 years’ experience in antibody and protein engineering within the academic or biopharma/biotech sectors
- 10 years managerial experience
- Extensive experience in antibody discovery using both in vivo and in vitro approaches
- Proficiency with various protein display systems, such as yeast, bacteria, phage, and mRNA display
- Skilled in library creation, selection, and enrichment analysis
- Deep knowledge of antibody structure function relationships and experience using evolutionary approaches to optimize antibody function and rational design, including utilization of protein design tools
- Detailed knowledge of current AI/ML approaches for protein structure and interaction predictions in the context of antibody discovery
- Knowledge of the biologics process from discovery to pre-IND
- Experience in managing and leading CROs
- Strong strategic vision and experience in developing and executing strategic plans aligned with organizational goals
- Accountable, meticulous with attention to detail, and able to multitask
- Strong teamwork and proactive communication skills
- Self-motivated and able to work independently in a cross-functional team environment
- Must be willing to work onsite 5 days a week
Seniority level
Seniority level
Director
Employment type
Employment type
Full-time
Job function
Job function
Engineering and Information Technology
Referrals increase your chances of interviewing at Calico Life Sciences by 2x
Sign in to set job alerts for “Senior Director of Engineering” roles.
Alameda, CA $169,300.00-$338,700.00 2 weeks ago
San Francisco, CA $100,000.00-$250,000.00 3 weeks ago
Director of Engineering, Revenue Cycle Management
Head of Engineering (Director/VP) - VC Backed Startups
San Francisco, CA $180,000.00-$300,000.00 3 months ago
San Francisco, CA $264,000.00-$342,000.00 1 day ago
Foster City, CA $210,375.00-$272,250.00 1 week ago
Director, Software Engineering (Analytics & Data) - 10401
San Francisco, CA $180,000.00-$287,500.00 2 weeks ago
Senior Engineering Director, Plant Development
Vice President of Engineering (VPE) - VC Backed Startups
San Francisco, CA $200,000.00-$350,000.00 3 months ago
San Francisco, CA $250,000.00-$295,000.00 4 days ago
San Mateo, CA $350,000.00-$500,000.00 5 days ago
Oakland, CA $195,000.00-$235,000.00 1 week ago
Menlo Park, CA $253,000.00-$314,000.00 2 weeks ago
San Francisco, CA $214,000.00-$230,000.00 4 weeks ago
Palo Alto, CA $248,700.00-$342,000.00 2 weeks ago
Director/Sr Director, Software Engineering
San Francisco, CA $211,500.00-$384,100.00 3 weeks ago
San Francisco, CA $210,000.00-$260,000.00 1 month ago
San Mateo, CA $391,590.00-$448,990.00 2 weeks ago
Sr. Director of Engineering - Developer Experience
Director - GenAI Transformational Leader
Director of Engineering, Shopping and E-commerce
Sr. Director, Engineering - Ads Measurement
Director of Engineering - VC Backed Startups
San Francisco, CA $190,000.00-$280,000.00 3 months ago
We’re unlocking community knowledge in a new way. Experts add insights directly into each article, started with the help of AI.
#J-18808-Ljbffr