Takeda Pharmaceuticals
Scientist Computational Biology (Biologics)
Takeda Pharmaceuticals, Boston, Massachusetts, United States, 02108
Biologics Discovery Scientist
The purpose of this position is to deliver on the priorities of Global Biologics research and Biologics Engineering and Antibody Discovery organization by contributing to the discovery, optimization, and engineering of the antibody and CAR-T cells by deep mining repertoire of therapeutic antibodies using NGS to accelerate programs to IND. Accountabilities: Develop and implement robust pipelines for analyzing large-scale bulk and single B-cell sequencing datasets for biologics discovery workflows. Improve antibody screening and in silico analysis workflows by implementing standard automated protocols for the antibody curation, annotation, and interpretation of large antibody-specific datasets. Lead the biologics discovery campaigns using well-designed, and optimized bioinformatics workflows to accelerate therapeutic discovery by analyzing sequencing datasets from various sources. Propose a rationale library design strategy based on the antibody selection output to further affinity mature and optimize biologics. Advance antibody sequences from in vitro (yeast and phage), in vivo (single/bulk B cells/VHH) or de novo (AI-based) platforms with the goal to deeply interrogate repertoires, expand functional sequence diversity, and affinity to accelerate the lead discovery. Collaborate with cross-functional teams to integrate sequencing data with other data generated from antibody discovery engine. Ability to use AWS and HCP infrastructure for additional compute needs. Use Docker and GitHub for reproducibility of workflow and version control, respectively. Develop UI to seamlessly integrate flow of sequencing data from various discovery platforms and relevant information. Meet established timelines, maintain accurate records of work, and present data at team, departmental, and company-wide meetings. Education & Competencies (Technical and Behavioral):
Education: BS, MS, or PhD in a relevant scientific field. Experience: If BS, then 11+ years. If MS, then 9+ years. If PhD, then 2-3 years of previous work experience. A strong background in computational biology and scientific programming languages (R/Python). In-depth experience analyzing NGS data, including B-cell receptor and antibody repertoire sequencing data and selection data from antibody surface display. Deep overall understanding of in vivo and in vitro antibody discovery platforms. Minimum 2 years of industry experience in hands-on NGS data analysis (RNAseq /scRNAseq) utilizing custom workflows and pipelines. Demonstrated ability to write, test, automate, and benchmark computational pipeline tools with a focus towards biologics discovery. Experience with AI/ML and deep learning-based methodology is a plus. Takeda Compensation and Benefits Summary We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices. For Location: Boston, MA U.S. Base Salary Range: $111,800.00 - $175,670.00 The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job. The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location. U.S. based employees may be eligible for short-term and/or long-term incentives. U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation. EEO Statement Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law. Locations
Boston, MA Worker Type
Employee Worker Sub-Type
Regular Time Type
Full time Job Exempt Yes
The purpose of this position is to deliver on the priorities of Global Biologics research and Biologics Engineering and Antibody Discovery organization by contributing to the discovery, optimization, and engineering of the antibody and CAR-T cells by deep mining repertoire of therapeutic antibodies using NGS to accelerate programs to IND. Accountabilities: Develop and implement robust pipelines for analyzing large-scale bulk and single B-cell sequencing datasets for biologics discovery workflows. Improve antibody screening and in silico analysis workflows by implementing standard automated protocols for the antibody curation, annotation, and interpretation of large antibody-specific datasets. Lead the biologics discovery campaigns using well-designed, and optimized bioinformatics workflows to accelerate therapeutic discovery by analyzing sequencing datasets from various sources. Propose a rationale library design strategy based on the antibody selection output to further affinity mature and optimize biologics. Advance antibody sequences from in vitro (yeast and phage), in vivo (single/bulk B cells/VHH) or de novo (AI-based) platforms with the goal to deeply interrogate repertoires, expand functional sequence diversity, and affinity to accelerate the lead discovery. Collaborate with cross-functional teams to integrate sequencing data with other data generated from antibody discovery engine. Ability to use AWS and HCP infrastructure for additional compute needs. Use Docker and GitHub for reproducibility of workflow and version control, respectively. Develop UI to seamlessly integrate flow of sequencing data from various discovery platforms and relevant information. Meet established timelines, maintain accurate records of work, and present data at team, departmental, and company-wide meetings. Education & Competencies (Technical and Behavioral):
Education: BS, MS, or PhD in a relevant scientific field. Experience: If BS, then 11+ years. If MS, then 9+ years. If PhD, then 2-3 years of previous work experience. A strong background in computational biology and scientific programming languages (R/Python). In-depth experience analyzing NGS data, including B-cell receptor and antibody repertoire sequencing data and selection data from antibody surface display. Deep overall understanding of in vivo and in vitro antibody discovery platforms. Minimum 2 years of industry experience in hands-on NGS data analysis (RNAseq /scRNAseq) utilizing custom workflows and pipelines. Demonstrated ability to write, test, automate, and benchmark computational pipeline tools with a focus towards biologics discovery. Experience with AI/ML and deep learning-based methodology is a plus. Takeda Compensation and Benefits Summary We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices. For Location: Boston, MA U.S. Base Salary Range: $111,800.00 - $175,670.00 The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job. The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location. U.S. based employees may be eligible for short-term and/or long-term incentives. U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation. EEO Statement Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law. Locations
Boston, MA Worker Type
Employee Worker Sub-Type
Regular Time Type
Full time Job Exempt Yes