GSK
Oligonucleotide Synthesis Principal Scientist
GSK, Cambridge, Massachusetts, United States, 02138
Oligo Synthesis Lab Position
The successful candidate will help to establish pre-clinical capabilities within GSK's new oligo synthesis lab. Areas of focus are SPOS of modalities such as ASOs, siRNA, SSO, and RNA editors screening, high-throughput automation, conjugates, and method development. Your expertise will enable us to solve complex chemical challenges, pushing the boundaries of what's possible in oligonucleotide therapeutics. This role will provide you the opportunity to lead key activities to progress your career, these responsibilities include some of the following: Establish pre-clinical oligonucleotide high-throughput and mid-scale synthesis capabilities of ASOs, siRNA, SSO, and RNA editors with routine and novel next generation amidite chemistries. Develop and maintain high-throughput automation workflows. Perform hands-on work, establish oligo synthesis workflows and draft SOPs in support of next generation chemistry and method development. Serve as the oligo synthesis SME for the team, representing oligo synthesis in various cross matrix meetings. Develop and maintain standard operating procedures (SOPs) for synthesis, processing, and purification to ensure high-quality, reproducible results. Work with the oligo analytical and conjugate chemistry teams to ensure accountability and excellence in oligonucleotide and conjugate synthesis. Train and/or build a small team to support synthesis capabilities. Collaborate and communicate across various teams to build robust workflows, or leverage internal resources to deliver on portfolio endpoints. Why You?
We are looking for professionals with these required skills to achieve our goals: PhD with 2+ years, or MS with 4+ or BS with 8+ years' experience in chemistry or chemical biology or related field. 2+ years of industry experience in modern synthetic chemistry methods, particularly nucleosides, nucleotides, and oligonucleotide synthesis, purification, and analysis. Familiarity with Mermade 192X with Poseidon software and KTA Oligosynt synthesizers, Cytiva, KTA Avant and Pure purification systems with Unicorn software, and LC/HRMS, UPHLC, LC/MS analytics. Expertise in oligonucleotide synthesis (SPOS), and biological familiarity of RNA therapeutics (e.g. ASO, siRNA, SSO, RNA Editors). Preferred Qualifications
If you have the following characteristics, it would be a plus: Minimum MS with 4+ years or above (or PhD +2) in Oligonucleotide synthesis and/or oligo chemistry Prior experience with team leadership, scientific and professional mentorship, and project management. Team-focused with strong initiative and ability to troubleshoot challenges and implement new solutions. Excellent written and verbal communication skills, attention to detail, organizational skills, and the ability to collaborate effectively with a team are required. Experience with oligonucleotide conjugation chemistries is desirable but not required. Sense of urgency, flexibility, independence and accountability. Ability to communicate both verbally and in writing with all levels both inside and outside of the organization. Maintain a high level of integrity while balancing multiple priorities and responsibilities. Must be a committed team player prepared to work in and embrace a team-based culture. GSK is a global biopharma company with a special purpose
to unite science, technology and talent to get ahead of disease together
so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns
as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology). Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves
feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together. If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US). GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.
The successful candidate will help to establish pre-clinical capabilities within GSK's new oligo synthesis lab. Areas of focus are SPOS of modalities such as ASOs, siRNA, SSO, and RNA editors screening, high-throughput automation, conjugates, and method development. Your expertise will enable us to solve complex chemical challenges, pushing the boundaries of what's possible in oligonucleotide therapeutics. This role will provide you the opportunity to lead key activities to progress your career, these responsibilities include some of the following: Establish pre-clinical oligonucleotide high-throughput and mid-scale synthesis capabilities of ASOs, siRNA, SSO, and RNA editors with routine and novel next generation amidite chemistries. Develop and maintain high-throughput automation workflows. Perform hands-on work, establish oligo synthesis workflows and draft SOPs in support of next generation chemistry and method development. Serve as the oligo synthesis SME for the team, representing oligo synthesis in various cross matrix meetings. Develop and maintain standard operating procedures (SOPs) for synthesis, processing, and purification to ensure high-quality, reproducible results. Work with the oligo analytical and conjugate chemistry teams to ensure accountability and excellence in oligonucleotide and conjugate synthesis. Train and/or build a small team to support synthesis capabilities. Collaborate and communicate across various teams to build robust workflows, or leverage internal resources to deliver on portfolio endpoints. Why You?
We are looking for professionals with these required skills to achieve our goals: PhD with 2+ years, or MS with 4+ or BS with 8+ years' experience in chemistry or chemical biology or related field. 2+ years of industry experience in modern synthetic chemistry methods, particularly nucleosides, nucleotides, and oligonucleotide synthesis, purification, and analysis. Familiarity with Mermade 192X with Poseidon software and KTA Oligosynt synthesizers, Cytiva, KTA Avant and Pure purification systems with Unicorn software, and LC/HRMS, UPHLC, LC/MS analytics. Expertise in oligonucleotide synthesis (SPOS), and biological familiarity of RNA therapeutics (e.g. ASO, siRNA, SSO, RNA Editors). Preferred Qualifications
If you have the following characteristics, it would be a plus: Minimum MS with 4+ years or above (or PhD +2) in Oligonucleotide synthesis and/or oligo chemistry Prior experience with team leadership, scientific and professional mentorship, and project management. Team-focused with strong initiative and ability to troubleshoot challenges and implement new solutions. Excellent written and verbal communication skills, attention to detail, organizational skills, and the ability to collaborate effectively with a team are required. Experience with oligonucleotide conjugation chemistries is desirable but not required. Sense of urgency, flexibility, independence and accountability. Ability to communicate both verbally and in writing with all levels both inside and outside of the organization. Maintain a high level of integrity while balancing multiple priorities and responsibilities. Must be a committed team player prepared to work in and embrace a team-based culture. GSK is a global biopharma company with a special purpose
to unite science, technology and talent to get ahead of disease together
so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns
as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology). Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves
feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together. If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US). GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.