VetJobs
Precision Medicine Director Obesity & Card - South San Francisco, CA
VetJobs, South San Francisco, California, us, 94083
Job Description
ATTENTION MILITARY AFFILIATED JOB SEEKERS
- Our organization works with partner companies to source qualified talent for their open roles. The following position is available to Veterans, Transitioning Military, National Guard and Reserve Members, Military Spouses, Wounded Warriors, and their Caregivers. If you have the required skill set, education requirements, and experience, please click the submit button and follow the next steps. Unless specifically stated otherwise, this role is "On-Site" at the location detailed in the job post.
Precision Medicine Director - Obesity & Cardiometabolic Disorders
What you will do Let's do this. Let's change the world. In this vital Director-level role, you will partner closely with Obesity and Cardiometabolic Disorders Therapeutic Area Scientists, as well as PKDM and Early Clinical Development teams. Your leadership will be essential in designing and executing translational and precision medicine strategies for early-stage assets, guiding them from Discovery through IND-enabling studies and into first-in-human (FIH) clinical trials. As a key translational thought leader, you will integrate cutting-edge scientific insights with strategic decision-making, steering the development of innovative therapies poised to redefine obesity and cardiometabolic care. You will collaborate with research project teams to identify clinically actionable biomarkers enabling: (1) Early demonstration of proof-of-concept (2) Dose determination during first-in-human studies (3) Validation and elucidation of mechanisms of action using translational datasets; and (4) Development and testing of patient-selection hypotheses in FIH trials. In collaboration with clinical teams, you will also establish reverse translational approaches, leveraging emerging clinical insights to investigate mechanisms of resistance and advance biomarker discovery.
Key Responsibilities Include: Biomarker & Data Strategy: Design and lead phase-appropriate biomarker strategies (pharmacodynamics, target engagement, mechanism-of-action indicators) to support preclinical decision-making and enable FIH trials. Leverage and interpret high-dimensional datasets (e.g., genomics, proteomics, single-cell data) to refine patient-selection hypotheses and deepen understanding of target biology. Strategic Leadership in Early Development: Serve as a senior translational leader responsible for building scientifically rigorous, mechanistically informed biomarker strategies that advance preclinical assets toward clinical testing. Collaborate closely with research teams to embed biomarker, MoA, and patient-selection hypotheses early in development, providing critical data to inform key clinical decisions. Integration Across Discovery and Early Clinical Development: Act as the translational medicine bridge between research and clinical development, aligning therapeutic hypotheses, discovery data, and biomarker concepts to achieve clinical readiness and early proof-of-concept. Mechanistic and Reverse Translational Focus: Champion reverse translational strategies to investigate disease heterogeneity, mechanisms of resistance, and biomarker discovery. Establish frameworks to generate actionable hypotheses around disease biology, drug MoA, and patient subpopulations. Cross-Functional Collaboration: Partner with Discovery Research, Clinical Pharmacology, Toxicology, Early Development, and Regulatory Affairs teams to ensure seamless progression from IND-enabling activities through initiation of FIH studies. External Innovation & Partnerships: Identify and cultivate strategic collaborations with academic institutions, consortia, and biotechnology companies, incorporating innovative tools, platforms, and datasets into Amgen's translational ecosystem. Maintain an influential presence as a thought leader within the external scientific community focused on obesity and cardiometabolic disorders. TA-Level Strategic Contributions: Provide scientific input into broader therapeutic area strategies, including target portfolio prioritization, endotype definition, and exploration of combination therapies grounded in human biology. Mentorship and Team Leadership: Mentor, develop, and provide strategic oversight to a team of biomarker scientists performing laboratory-based research and serving as active members on project teams.
Additional Qualifications/Responsibilities
We are all different, yet we all use our unique contributions to serve patients. The [vital attribute] professional we seek is a [type of person] with these qualifications.
Basic Qualifications:
Doctorate degree and 4 years of relevant industry or academic experience,
OR
Master's degree and 7 years of relevant experience,
OR
Bachelor's degree and 9 years of relevant experience.
Preferred Qualifications:
PhD or MD/PhD with 6+ years of progressive experience in translational research within the biopharmaceutical industry, with a strong focus on metabolic or cardiometabolic diseases. Proven experience specifically in obesity research is strongly preferred. Demonstrated leadership as Project Team Lead for cardiometabolic or obesity programs, from early research stages through IND submission. Extensive experience as a biomarker lead on clinical-stage assets, with deep mechanistic expertise in obesity biology, insulin resistance, dyslipidemia, and cardiovascular pathophysiology. Recognized contributor within the scientific community through publications, presentations, or leadership roles in relevant academic or industry forums. Strong expertise in biomarker discovery and validation, multi-omics-driven stratification strategies, and patient segmentation informed by human biology. Demonstrated ability to integrate and interpret complex scientific data to support strategic development decisions, coupled with an enduring curiosity for translational science and fundamental principles of human pathophysiology. Proven ability to influence effectively in cross-functional, matrixed organizations through strong communication and leadership without direct authority. Demonstrated leadership experience managing and mentoring a team of junior Precision Medicine Scientists.
ATTENTION MILITARY AFFILIATED JOB SEEKERS
- Our organization works with partner companies to source qualified talent for their open roles. The following position is available to Veterans, Transitioning Military, National Guard and Reserve Members, Military Spouses, Wounded Warriors, and their Caregivers. If you have the required skill set, education requirements, and experience, please click the submit button and follow the next steps. Unless specifically stated otherwise, this role is "On-Site" at the location detailed in the job post.
Precision Medicine Director - Obesity & Cardiometabolic Disorders
What you will do Let's do this. Let's change the world. In this vital Director-level role, you will partner closely with Obesity and Cardiometabolic Disorders Therapeutic Area Scientists, as well as PKDM and Early Clinical Development teams. Your leadership will be essential in designing and executing translational and precision medicine strategies for early-stage assets, guiding them from Discovery through IND-enabling studies and into first-in-human (FIH) clinical trials. As a key translational thought leader, you will integrate cutting-edge scientific insights with strategic decision-making, steering the development of innovative therapies poised to redefine obesity and cardiometabolic care. You will collaborate with research project teams to identify clinically actionable biomarkers enabling: (1) Early demonstration of proof-of-concept (2) Dose determination during first-in-human studies (3) Validation and elucidation of mechanisms of action using translational datasets; and (4) Development and testing of patient-selection hypotheses in FIH trials. In collaboration with clinical teams, you will also establish reverse translational approaches, leveraging emerging clinical insights to investigate mechanisms of resistance and advance biomarker discovery.
Key Responsibilities Include: Biomarker & Data Strategy: Design and lead phase-appropriate biomarker strategies (pharmacodynamics, target engagement, mechanism-of-action indicators) to support preclinical decision-making and enable FIH trials. Leverage and interpret high-dimensional datasets (e.g., genomics, proteomics, single-cell data) to refine patient-selection hypotheses and deepen understanding of target biology. Strategic Leadership in Early Development: Serve as a senior translational leader responsible for building scientifically rigorous, mechanistically informed biomarker strategies that advance preclinical assets toward clinical testing. Collaborate closely with research teams to embed biomarker, MoA, and patient-selection hypotheses early in development, providing critical data to inform key clinical decisions. Integration Across Discovery and Early Clinical Development: Act as the translational medicine bridge between research and clinical development, aligning therapeutic hypotheses, discovery data, and biomarker concepts to achieve clinical readiness and early proof-of-concept. Mechanistic and Reverse Translational Focus: Champion reverse translational strategies to investigate disease heterogeneity, mechanisms of resistance, and biomarker discovery. Establish frameworks to generate actionable hypotheses around disease biology, drug MoA, and patient subpopulations. Cross-Functional Collaboration: Partner with Discovery Research, Clinical Pharmacology, Toxicology, Early Development, and Regulatory Affairs teams to ensure seamless progression from IND-enabling activities through initiation of FIH studies. External Innovation & Partnerships: Identify and cultivate strategic collaborations with academic institutions, consortia, and biotechnology companies, incorporating innovative tools, platforms, and datasets into Amgen's translational ecosystem. Maintain an influential presence as a thought leader within the external scientific community focused on obesity and cardiometabolic disorders. TA-Level Strategic Contributions: Provide scientific input into broader therapeutic area strategies, including target portfolio prioritization, endotype definition, and exploration of combination therapies grounded in human biology. Mentorship and Team Leadership: Mentor, develop, and provide strategic oversight to a team of biomarker scientists performing laboratory-based research and serving as active members on project teams.
Additional Qualifications/Responsibilities
We are all different, yet we all use our unique contributions to serve patients. The [vital attribute] professional we seek is a [type of person] with these qualifications.
Basic Qualifications:
Doctorate degree and 4 years of relevant industry or academic experience,
OR
Master's degree and 7 years of relevant experience,
OR
Bachelor's degree and 9 years of relevant experience.
Preferred Qualifications:
PhD or MD/PhD with 6+ years of progressive experience in translational research within the biopharmaceutical industry, with a strong focus on metabolic or cardiometabolic diseases. Proven experience specifically in obesity research is strongly preferred. Demonstrated leadership as Project Team Lead for cardiometabolic or obesity programs, from early research stages through IND submission. Extensive experience as a biomarker lead on clinical-stage assets, with deep mechanistic expertise in obesity biology, insulin resistance, dyslipidemia, and cardiovascular pathophysiology. Recognized contributor within the scientific community through publications, presentations, or leadership roles in relevant academic or industry forums. Strong expertise in biomarker discovery and validation, multi-omics-driven stratification strategies, and patient segmentation informed by human biology. Demonstrated ability to integrate and interpret complex scientific data to support strategic development decisions, coupled with an enduring curiosity for translational science and fundamental principles of human pathophysiology. Proven ability to influence effectively in cross-functional, matrixed organizations through strong communication and leadership without direct authority. Demonstrated leadership experience managing and mentoring a team of junior Precision Medicine Scientists.