Expert II Data Science, Cargo Design

This position will be located at the San Diego site and will not have the ability to be located remotely. Please note that this role would not provide relocation and only local candidates will be considered. Internal Title: Expert II Data Science We are recruiting a highly motivated and innovative Bioinformatics/Data Scientist, to join our multidisciplinary team advancing next-generation gene therapy programs. This role offers a unique opportunity to drive the design, optimization, and evaluation of gene therapy payloads, working at the intersection of computational biology, high-throughput experimentation, and therapeutic discovery. The successful candidate will contribute to projects that integrate cutting-edge bioinformatics, machine learning, and functional genomics to accelerate the development of transformative gene therapies. About the Role Key Responsibilities: Designing, implementing, and maintainingcustom computational pipelinesfor analysis of bulk and single-cell sequencing data, includingbut not limited to RNA-Seq, smRNA-seq, scRNA-seq, and scATAC-seq. Applyingmachine learning, statistical modeling, and data integrationapproaches to guide large-scale functional screens with the goal of identifying and optimizing functional elements for gene therapy payloads. Developingscalable, reproducible, and well-documented pipelinesfor quality control, processing, and integrative analysisof diverse high-throughput sequencing datasets. Integratingpublicly available and internal datasetsto uncover actionable biological insights that inform payload design. Staying current with emerging technologies and advances inbioinformatics, gene therapy, and synthetic biology, and proactively propose innovative approaches to improve experimental design and analysis. Presenting results, methodologies, and key insights to multidisciplinary teams and stakeholders throughclear visualizations, written reports, and scientific presentations. Educational Background: Ph.D Bioinformatics, Computational Biology, Computer Science (recent Ph.D. welcome to apply) MS degree in bioinformatics, computational biology, computer science, structural biology or a related field with 4 years of relevant industry research experience Proficiency in developing and deployingNGS data analysis pipelines, with expertise in Python, R, and workflow management tools. Hands-on experience withsingle-cell data analysisand familiarity with key tools and algorithms in the field. Strong track record of applyingmachine learningto genomics problems, supported bypeer-reviewed publications. Excellent interpersonal and written communication skills; capable of effectively engaging with collaborators across scientific and technical disciplines. Independent and critical thinker with strongproblem-solving skills, a collaborative mindset, and the ability to thrive in a dynamic team environment. Desired Requirements Solid understanding ofgene therapy principles, including AAV vector engineering, promoter/enhancer function, and payload design considerations. Novartis Compensation and Benefit Summary: The pay range for this position at commencement of employment is expected to be between: $103,600 and $192,400/year; however, while salary ranges are effective from 1/1/25 through 12/31/25, fluctuations in the job market may necessitate adjustments to pay ranges during this period. Further, final pay determinations will depend on various factors, including, but not limited to geographical location, experience level, knowledge, skills, and abilities. The total compensation package for this position may also include other elements, including a sign-on bonus, restricted stock units, and discretionary awards in addition to a full range of medical, financial, and/or other benefits (including 401(k) eligibility and various paid time off benefits, such as vacation, sick time, and parental leave), dependent on the position offered. Details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an at-will position and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients' lives. Ready to create a brighter future together? Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, sex, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. Accessibility & Reasonable Accommodations The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or to perform the essential functions of a position, please send an e-mail to us.reasonableaccommodations@ or call +1(877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Division Biomedical Research Business Unit Pharma Research Location USA State California Site LaJolla/SD Company / Legal Entity U175 (FCRS = US175) Novartis Institutes for BioMedical Research, Inc. #J-18808-Ljbffr