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Stoke Therapeutics

Director, Engineering & Facilities

Stoke Therapeutics, Bedford, Massachusetts, us, 01730

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About Stoke:

Stoke Therapeutics (Nasdaq: STOK) is a biotechnology company dedicated to restoring protein expression by harnessing the body's potential with RNA medicine. Stoke is developing antisense oligonucleotides (ASOs) to selectively restore naturally occurring protein levels. Stoke's first medicine in development, zorevunersen, has demonstrated the potential for disease modification in patients with Dravet syndrome and is currently being evaluated in a Phase 3 study. Stoke entered into a strategic collaboration with Biogen in 2025 to develop and commercialize zorevunersen for Dravet syndrome. Under the collaboration, Stoke retains exclusive rights for zorevunersen in the United States, Canada, and Mexico; Biogen receives exclusive rest of world commercialization rights

Stoke's initial focus for its TANGO platform is on diseases of the central nervous system and the eye that are caused by a loss of ~50% of normal protein levels (haploinsufficiency).

Stoke has identified STK-002 as a clinical candidate for the potential treatment of autosomal dominant optic atrophy (ADOA), the most common inherited optic nerve disorder. The company is also pursuing a potential new medicine for Syngap1, a severe and rare neurodevelopmental disorder, in collaboration with Acadia Pharmaceuticals.

Proof of concept has been demonstrated in other organs, tissues, and systems, supporting broad potential for the Company's proprietary approach.

Position Purpose:

We are seeking a Director, Engineering & Facilities to manage the ongoing operations and labs within our current headquarters in Bedford. Importantly, this person will also oversee and manage alongside the Chief Financial Officer the ongoing search for a potential new headquarters for Stoke. Therefore, this role is critical not only to develop an efficient, safe, and scalable environment across both office and lab settings, but also an opportunity to play an important role in Stoke's potential move into our new home. It's a hands-on, strategic opportunity for someone who thrives in a fast-paced environment. This position will report into the Chief Financial Officer.

Key Responsibilities: Help manage the process for Stoke's potential new headquarters search. Project manage construction of new offices, if applicable. Oversee technical aspects of new lab construction, including ensuring sufficient lab space and understanding building requirements. Oversee day-to-day operations of the facilities and the functioning of all building systems. Support the design, construction, startup and operation of all locations. Supervise external real estate, architectural, engineering and contractor relationships. Proactively engage with internal cross-functional teams to achieve site goals and ensure the facility is operating smoothly and in compliance with all health and safety standards. Develop and formalize approval of documents related to site operations including SOPs, safety training, policies and procedures. Ensure building operations comply with all local building codes, zoning laws and regulations. Establish and maintain relationships and contracts with external vendors for services such as ULS inventory management, Airgas, FedEx, and hazardous waste disposal. Review fixed asset inventory and update as required. Maintain and improve site compliance related to environment, health, and safety. Develop and implement processes necessary to operate the facility, including non-GMP cleaning/housekeeping, badging/security, and pest control. Make recommendations to promote efficiencies and apply a proactive approach to potential operational/environmental hazards/risks. Manage projects in support of space planning and expansion across all locations to meet hiring requirements. Develop and maintain budgets and long-range facilities plans based on company growth and future needs. Additional responsibilities as assigned. Required Skills & Experience:

Bachelor's degree in engineering or related discipline preferred or equivalent combination of education and work-related experience. Minimum of 10 years overall experience in or related to biotechnology or pharmaceutical industry required. Must have experience in maintenance and construction projects and service vendor management. Significant project management skills in all areas of facilities operations. Ability to read and interpret architectural prints, job specifications etc. Knowledge of OSHA guidelines, and other federal, state and local regulations is required. Strong focus on working collegially with team members from across the organization. Pharmaceutical GMP and GLP knowledge preferred. Experience with asset, maintenance, and facilities management systems. Working knowledge of EH&S. Meet the physical requirements of this role including stooping, standing, walking, climbing stairs/ladders, and the ability to lift/carry up to 50 lbs.

Location(s):

Stoke is located in Bedford, MA. This position is onsite with an office setting based in Bedford, MA.

Travel:

This position will require approximately 5% travel.

Culture & Values:

At Stoke, we believe that innovation, the ability to successfully advance our ground-breaking science and having fun as a team are enhanced by being together in person, at least periodically. We allow for flexibility in work arrangements that balance individual's needs and preferences with the needs of our business and our desire to foster a culture of collaboration and innovation.

Our values guide our work to deliver meaningful medicines for people who need them. We are committed to being true to ourselves, to our colleagues, and to the people with severe diseases who are counting on us. We embrace diversity within a unique culture that is defined by our values. Our employee-led Diversity, Inclusion, and Belonging Committee (DIB) underscores the importance of DIB to who we are and what we do. Benefits & Compensation:

At Stoke Therapeutics we are proud to offer comprehensive and competitive employee benefits, including medical, dental and vision insurance; life, long and short-term disability insurance; Paid Parental Leave; a 401K program with company match, unlimited vacation time, and an Employee Stock Purchase Program (ESPP). Compensation is market competitive for the industry and directly commensurate with experience. All positions are bonus and stock eligible.

Interested candidates: Please visit Stoke's website to learn more and apply directly to the position listed on our Career Center.

For more information, visit stoketherapeutics.com or follow the company on X at @StokeTx.

All applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, physical or mental disability or protected veteran status.

Stoke participates in E-Verify.