AstraZeneca
Senior Scientist, BioScience, In-vitro Discovery
AstraZeneca, Gaithersburg, Maryland, United States, 20877
Senior Scientist, BioScience, In-vitro Discovery
Are you driven by the desire to discover and deliver life-changing medicines? Do you have expertise in Biologics Engineering and want to make a significant impact in a company that transforms scientific ideas into reality? AstraZeneca is looking for a passionate individual to join our team and contribute to the development of groundbreaking medicines! Accountabilities
As a Senior Scientist, you will play a pivotal role in advancing our biologics pipeline. You will independently design and execute discovery campaigns using phage and yeast-display technologies. Your responsibilities will include recovering yeast plasmids, preparing samples for NGS data generation, analyzing NGS data with software like Geneious Biologics, and selecting hit lists for antibody production. You will contribute to technology platform builds, streamline discovery workflows, and present data as a lead scientist in multidisciplinary project teams. Collaboration across multiple groups in a matrixed environment is essential. Essential Skills/Experience
A PhD, or equivalent experience, in Molecular Biology, Biochemistry, Immunology, with 0-6 years of post-doctoral experience in a relevant research area, a Master's degree in a related field with 2+ years of relevant laboratory experience, or a Bachelor's degree in Molecular Biology, Biochemistry, Immunology or related disciplines with 5+ years of laboratory experience. Industry experience is a plus but not required. Extensive and current hands-on experience with phage and yeast-display technology for antibody discovery. Proven hands-on experience with NGS data generation (sample prepping) and sequence analysis. Data science and/or coding (python) skills highly desirable. Experience in high-throughput cloning, DNA sequence analysis, protein expression and purification, ELISA, flow cytometry, and tissue culture. Ability to work independently and in a team setting. Self-motivated, diligent, and flexible in accommodating shifting priorities. Strong communication and interpersonal skills, both oral and written, with supervisor, team, and various cross-functional project team members. Maintain accurate and well-organized laboratory records, including worksheets, lab notebooks, inventories, and databases. Desirable Skills/Experience
Experience working with various antibody formats including VHH, scFv and Fab. Familiarity with handling large datasets; data science skills are a plus. Transfection/electroporation, culturing and expansion of mammalian cells. Experience with ELISA, MSD, cytotox and biolayer interferometry binding assays highly desirable. Experience with electronic notebook keeping and data entry using Gene Data Biologics. AstraZeneca offers an empowering environment where you can act swiftly on smart risks. Our dynamic approach keeps us ahead in the fast-paced Oncology field. We encourage fearless decision-making and constructive challenges while always following scientific evidence. With one of the broadest Oncology pipelines in the industry, you'll have the opportunity to work with novel drugs and make bold moves that transform cancer treatment.
Are you driven by the desire to discover and deliver life-changing medicines? Do you have expertise in Biologics Engineering and want to make a significant impact in a company that transforms scientific ideas into reality? AstraZeneca is looking for a passionate individual to join our team and contribute to the development of groundbreaking medicines! Accountabilities
As a Senior Scientist, you will play a pivotal role in advancing our biologics pipeline. You will independently design and execute discovery campaigns using phage and yeast-display technologies. Your responsibilities will include recovering yeast plasmids, preparing samples for NGS data generation, analyzing NGS data with software like Geneious Biologics, and selecting hit lists for antibody production. You will contribute to technology platform builds, streamline discovery workflows, and present data as a lead scientist in multidisciplinary project teams. Collaboration across multiple groups in a matrixed environment is essential. Essential Skills/Experience
A PhD, or equivalent experience, in Molecular Biology, Biochemistry, Immunology, with 0-6 years of post-doctoral experience in a relevant research area, a Master's degree in a related field with 2+ years of relevant laboratory experience, or a Bachelor's degree in Molecular Biology, Biochemistry, Immunology or related disciplines with 5+ years of laboratory experience. Industry experience is a plus but not required. Extensive and current hands-on experience with phage and yeast-display technology for antibody discovery. Proven hands-on experience with NGS data generation (sample prepping) and sequence analysis. Data science and/or coding (python) skills highly desirable. Experience in high-throughput cloning, DNA sequence analysis, protein expression and purification, ELISA, flow cytometry, and tissue culture. Ability to work independently and in a team setting. Self-motivated, diligent, and flexible in accommodating shifting priorities. Strong communication and interpersonal skills, both oral and written, with supervisor, team, and various cross-functional project team members. Maintain accurate and well-organized laboratory records, including worksheets, lab notebooks, inventories, and databases. Desirable Skills/Experience
Experience working with various antibody formats including VHH, scFv and Fab. Familiarity with handling large datasets; data science skills are a plus. Transfection/electroporation, culturing and expansion of mammalian cells. Experience with ELISA, MSD, cytotox and biolayer interferometry binding assays highly desirable. Experience with electronic notebook keeping and data entry using Gene Data Biologics. AstraZeneca offers an empowering environment where you can act swiftly on smart risks. Our dynamic approach keeps us ahead in the fast-paced Oncology field. We encourage fearless decision-making and constructive challenges while always following scientific evidence. With one of the broadest Oncology pipelines in the industry, you'll have the opportunity to work with novel drugs and make bold moves that transform cancer treatment.