NewLimit
Scientist/Senior Scientist, Metabolism
NewLimit - South San Francisco, California, us, 94083
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Overview
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Overview
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Scientist/Senior Scientist, Metabolism
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Scientist/Senior Scientist, Metabolism
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NewLimit Company info
NewLimit is a biotechnology company working to radically extend human healthspan. We’re developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale.
Description
NewLimit is seeking an scientist with experience in liver biology and metabolism to join our Metabolism team. Our Metabolism team is developing reprogramming medicines to restore youthful function in aged hepatocytes in the context of metabolic disease. In this role, you will develop and perform assays for hepatocyte function, contribute to team decision making, and serve as a subject matter expert within NewLimit to enable our therapeutic development efforts.
As a Scientist On Our Team, You Will
Collaborate with our Single Cell Technology, Epigenetic Editing, and Predictive Modeling teams to design, build, and test epigenetic reprogramming interventions for aged and diseased hepatocytes Develop assays to measure hepatocyte function both ex vivo and in vivo Evaluate epigenetic reprogramming payloads using ex vivo and in vivo functional assays to select therapeutic candidates Develop methods for in vivo delivery of nucleic acid payloads to hepatocytes in collaboration with our Epigenetic Editing team Analyze and interpret experimental data to drive pre-clinical decision making
Requirements
Ph.D. in cell biology, molecular biology, biochemistry or a related field or equivalent industry experience (5+ years) Experience with primary liver cell isolation and functional characterization Experience working with mouse models of liver dysfunction Experience with transgenic manipulation of liver cells either ex vivo or in vivo (e.g. using viral vectors, nucleic acid delivery)
Nice to have
History of contributing to a drug development program at the pre-clinical or clinical development stage Experience leading the design and execution of pre-clinical studies in mouse models Experience with single cell genomics methods Experience with pooled screening approaches using bulk or single cell read-outs (e.g. CRISPR fitness screens, Perturb/CROP-seq)
Benefits
NewLimit offers generous benefits to ensure our team can focus on our mission:
Health, dental, and vision insurance 401(k) with company match Paid parental leave Industry-leading paid time off (PTO) — 20 days/year for all employees + holidays Meals and snacks on-site
Seniority level
Seniority level Mid-Senior level Employment type
Employment type Full-time Job function
Job function Research, Analyst, and Information Technology Referrals increase your chances of interviewing at NewLimit by 2x Sign in to set job alerts for “Senior Scientist” roles.
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We’re unlocking community knowledge in a new way. Experts add insights directly into each article, started with the help of AI.
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Scientist/Senior Scientist, Metabolism
role at
NewLimit Join to apply for the
Scientist/Senior Scientist, Metabolism
role at
NewLimit Company info
NewLimit is a biotechnology company working to radically extend human healthspan. We’re developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale.
Description
NewLimit is seeking an scientist with experience in liver biology and metabolism to join our Metabolism team. Our Metabolism team is developing reprogramming medicines to restore youthful function in aged hepatocytes in the context of metabolic disease. In this role, you will develop and perform assays for hepatocyte function, contribute to team decision making, and serve as a subject matter expert within NewLimit to enable our therapeutic development efforts.
As a Scientist On Our Team, You Will
Collaborate with our Single Cell Technology, Epigenetic Editing, and Predictive Modeling teams to design, build, and test epigenetic reprogramming interventions for aged and diseased hepatocytes Develop assays to measure hepatocyte function both ex vivo and in vivo Evaluate epigenetic reprogramming payloads using ex vivo and in vivo functional assays to select therapeutic candidates Develop methods for in vivo delivery of nucleic acid payloads to hepatocytes in collaboration with our Epigenetic Editing team Analyze and interpret experimental data to drive pre-clinical decision making
Requirements
Ph.D. in cell biology, molecular biology, biochemistry or a related field or equivalent industry experience (5+ years) Experience with primary liver cell isolation and functional characterization Experience working with mouse models of liver dysfunction Experience with transgenic manipulation of liver cells either ex vivo or in vivo (e.g. using viral vectors, nucleic acid delivery)
Nice to have
History of contributing to a drug development program at the pre-clinical or clinical development stage Experience leading the design and execution of pre-clinical studies in mouse models Experience with single cell genomics methods Experience with pooled screening approaches using bulk or single cell read-outs (e.g. CRISPR fitness screens, Perturb/CROP-seq)
Benefits
NewLimit offers generous benefits to ensure our team can focus on our mission:
Health, dental, and vision insurance 401(k) with company match Paid parental leave Industry-leading paid time off (PTO) — 20 days/year for all employees + holidays Meals and snacks on-site
Seniority level
Seniority level Mid-Senior level Employment type
Employment type Full-time Job function
Job function Research, Analyst, and Information Technology Referrals increase your chances of interviewing at NewLimit by 2x Sign in to set job alerts for “Senior Scientist” roles.
Menlo Park, CA $100,000.00-$150,000.00 3 weeks ago Principal/Senior Scientist, Analytical Science
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South San Francisco, CA $94,000.00-$178,500.00 4 days ago South San Francisco, CA $170,000.00-$200,000.00 3 weeks ago Research Scientist - Computational Chemistry
Oakland, CA $150,000.00-$200,000.00 2 weeks ago Scientist 1/2/Senior Scientist, Analytical Development
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Brisbane, CA $140,250.00-$216,500.00 3 days ago Sr. Scientist, Small-Molecule Drug Substance Development and Manufacturing
Hayward, CA $150,000.00-$170,000.00 2 weeks ago Senior Scientist - Chemical Development and Drug Substance Manufacturing
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San Mateo, CA $183,690.00-$225,030.00 4 days ago Senior Scientist, Quality Control Biologics (Analytical Lifecycle Management)
Foster City, CA $157,590.00-$203,940.00 1 week ago Technical Development Principal Scientist
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South San Francisco, CA $166,000.00-$207,000.00 5 days ago Senior Scientist -- Pre-Pivotal Biologics, Analytical Operations
Foster City, CA $169,320.00-$219,120.00 6 days ago Brisbane, CA $140,250.00-$216,500.00 1 day ago Principal Scientist, Small Molecule Analytical Sciences
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We’re unlocking community knowledge in a new way. Experts add insights directly into each article, started with the help of AI.
#J-18808-Ljbffr