Natera
Scientist R&D, Reagent DevelopmentSan Francisco, CA
Natera - San Francisco, California, United States, 94188
Work at Natera
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Overview
Scientist R&D, Reagent Development
We are seeking a meticulous and dedicated Scientist for reagent development and quality control assay development. The Scientist will join a cross-functional team of assay development scientists, bioinformaticians, and engineers who are tasked with developing the scalable and robust platforms that underlie many of Natera's clinical assays. In this role, the Scientist will contribute to new product development by characterizing reagent performance and risks, establishing quality control assays and manufacturing processes, and transferring the assays and processes to Operations. Candidates must have experience with reagent development and laboratory automation for next-generation sequencing-based clinical assays in an R&D setting. Primary Responsibilities: Plan, manage, and execute projects to meet requirements and timelines. Develop and optimize reagents (enzymes, buffers, oligonucleotides, etc.) for use in NGS-based clinical assays. Independently design and execute experiments for characterizing reagent performance, formulation, stability, and manufacturing tolerance. Design, develop, and validate quality control assays and associated analysis pipelines for incoming and manufactured reagents, either independently or in collaboration with other assay development scientists, automation engineers, and bioinformaticians. Perform data analysis, interpret results, and decide on next steps. Document results, author SOPs, and coordinate tech transfer to the Operations team. Perform other duties as assigned. Qualifications: Bachelor's degree in molecular biology, biochemistry, or closely related field with 6+ years experience in assay development for the life science industry. Master's degree in molecular biology, biochemistry, or closely related field with 4+ years experience in assay development for the life science industry. Doctorate in molecular biology, biochemistry, or closely related field with 1+ years experience in assay development for the life science industry. Knowledge, Skills, and Abilities: History of success in reagent development or quality control assay development in an R&D environment. Extensive hands-on experience with various molecular biology techniques including but not limited to: next generation sequencing, PCR/qPCR, and nucleic acid extraction and quantification. Strong understanding of molecular biology and the chemistry underlying nucleic acid extraction, PCR, library preparation, and next-generation sequencing. Ability to independently perform moderate to high complexity experiments either manually or with liquid handler support. Must be able to independently design and execute experiments, interpret results, and decide on next steps. Must have experience working with next-generation sequencing data and performing data analysis in Excel, JMP, or similar software. Must have good communication and time management skills. Coding proficiency (Python or R) is a plus. Liquid handler method development experience is a plus.
We are seeking a meticulous and dedicated Scientist for reagent development and quality control assay development. The Scientist will join a cross-functional team of assay development scientists, bioinformaticians, and engineers who are tasked with developing the scalable and robust platforms that underlie many of Natera's clinical assays. In this role, the Scientist will contribute to new product development by characterizing reagent performance and risks, establishing quality control assays and manufacturing processes, and transferring the assays and processes to Operations. Candidates must have experience with reagent development and laboratory automation for next-generation sequencing-based clinical assays in an R&D setting. Primary Responsibilities: Plan, manage, and execute projects to meet requirements and timelines. Develop and optimize reagents (enzymes, buffers, oligonucleotides, etc.) for use in NGS-based clinical assays. Independently design and execute experiments for characterizing reagent performance, formulation, stability, and manufacturing tolerance. Design, develop, and validate quality control assays and associated analysis pipelines for incoming and manufactured reagents, either independently or in collaboration with other assay development scientists, automation engineers, and bioinformaticians. Perform data analysis, interpret results, and decide on next steps. Document results, author SOPs, and coordinate tech transfer to the Operations team. Perform other duties as assigned. Qualifications: Bachelor's degree in molecular biology, biochemistry, or closely related field with 6+ years experience in assay development for the life science industry. Master's degree in molecular biology, biochemistry, or closely related field with 4+ years experience in assay development for the life science industry. Doctorate in molecular biology, biochemistry, or closely related field with 1+ years experience in assay development for the life science industry. Knowledge, Skills, and Abilities: History of success in reagent development or quality control assay development in an R&D environment. Extensive hands-on experience with various molecular biology techniques including but not limited to: next generation sequencing, PCR/qPCR, and nucleic acid extraction and quantification. Strong understanding of molecular biology and the chemistry underlying nucleic acid extraction, PCR, library preparation, and next-generation sequencing. Ability to independently perform moderate to high complexity experiments either manually or with liquid handler support. Must be able to independently design and execute experiments, interpret results, and decide on next steps. Must have experience working with next-generation sequencing data and performing data analysis in Excel, JMP, or similar software. Must have good communication and time management skills. Coding proficiency (Python or R) is a plus. Liquid handler method development experience is a plus.