Scientist I, Proteomics

Description Company Overview: Vividion is a next generation biotechnology company based in San Diego that is leveraging its proprietary chemical proteomics platform to conduct proteome-wide footprinting of drug-protein interactions with unprecedented breadth and precision. Our technology allows us to screen, identify and optimize novel drugs that selectively bind virtually any protein, including proteins previously considered “undruggable”. Our pipeline and emerging programs reflect a matured and productive platform capable of delivering first in class drugs utilizing novel mechanisms of action (allosteric inhibitors, protein-protein interaction inhibitors, functional activators, degraders etc.) against undruggable targets in the oncology and immunology space. We prize scientific excellence, creativity, team players and we are committed to continued innovation. We have worked hard to create a collaborative and dynamic work culture where your ideas and discoveries are valued and will have an impact. We are growing and there are opportunities for mentorship and career progression. Vividion has been recognized as a Top Workplace by The San Diego Union-Tribune in 2022, 2023, and 2024. Job Summary: Vividion Therapeutics is seeking a scientist who is passionate about harnessing the power of proteomics to probe biology and identify new drug targets. In this position, the successful candidate will contribute to the identification of novel chemical matter and undruggable targets using our state-of-the-art chemical proteomics platform. The candidate will perform a mix of mass-spectrometry-based proteomics and molecular biology experiments to support projects at the discovery, enablement and pre-clinical stage. Additionally, this position will contribute to the expansion of our existing platform by implementing high throughput workflows for new chemical probes. Requirements Experience and education requirements: Ph.D. (or equivalent experience) in mass-spectrometry based proteomics or chemical biology Experience operating and maintaining orbitrap mass spectrometers and associated nano-LC systems Demonstrated experience in acquiring, analyzing and interpreting proteomics datasets (such as PRM, TMT, and DIA data); experience with targeted proteomics is a plus Experience preparing samples for MS analysis utilizing workflows that include peptide enrichment, protein enrichment or PTM enrichment Experience transforming assays from low throughput to robust high throughput assays Experience in chemical biology, molecular biology, or biochemistry Experience in cell culture (cell line maintenance, transient transfections, stable cell line generation, CRISPER editing) and molecular biology Required Key Attributes: Excellent organization and communication skills; ability to prioritize tasks and manage time effectively; attention to detail and good documentation habits Be a team player and strong individual contributor, flexible, and able to handle multiple tasks and deliver high quality results under tight timelines Pay & Benefits: The anticipated base salary for this position ranges from $105,000 to $120,000 depending on relevant skills, competencies, experience, and education. In addition, this position is eligible for target bonus, long-term-incentives, 401k retirement savings plan with company match, and a comprehensive benefits package which includes medical, dental, vision, life, and disability insurance. EEO & Employment Eligibility: Vividion Therapeutics, Inc. is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status. Privacy Policy: The protection of your personal information is a commitment we take seriously. For information regarding our Privacy Policy (CA candidates) please visit https://vividion.com/publication/privacy-noticeforcalifornia-candidates/.

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