Immunome
Scientist II, DMPK
Immunome is a clinical-stage targeted oncology company committed to developing first-in-class and best-in-class targeted therapies designed to improve outcomes for cancer patients. We are advancing an innovative portfolio of therapeutics, drawing on leadership that previously played key roles in the design, development, and commercialization of cutting-edge targeted cancer therapies, including antibody-drug conjugate therapies (ADCs). Our most advanced pipeline programs are varegacestat (formerly AL102), a gamma secretase inhibitor which is currently in a Phase 3 trial for treatment of desmoid tumors; IM-1021, a ROR1-targeted ADC which is currently in a Phase 1 trial; and IM-3050, a FAP-targeted radioligand, which recently received IND clearance. Our pipeline also includes IM-1617, IM-1335, and IM-1340, all of which are preclinical ADCs pursuing undisclosed targets with expression in multiple solid tumors. The Scientist II, DMPK will contribute to the design and execution of nonclinical pharmacokinetics/ADME strategies to support oncology drug candidates from discovery through development. This role will partner closely with cross-functional teams to deliver high-quality data that informs decision-making and regulatory submissions. Reporting to the Executive Director, ADME, the Scientist II will work on multiple modalities, with a strong emphasis on ADC programs. Responsibilities Design and execute stage-appropriate DMPK/ADME studies to support candidate selection, clinical development, and regulatory submissions. Collaborate with cross-functional teams to ensure integration of DMPK considerations into program strategy and timelines. Analyze PK, TK, and PKPD data, perform modeling and simulation, and provide clear interpretation to inform program decisions. Participate in Translational Sciences and Development team activities, contributing scientific expertise in DMPK. Represent the ADME function at internal and external meetings, in collaboration with senior scientists, communicating timelines, data, and implications effectively. Maintain awareness of evolving best practices and regulatory expectations in DMPK sciences. Qualifications PhD in a relevant discipline with 02 years of industry experience in DMPK/ADME, or MS with 5+ years relevant industry experience. Experience with ADCs required; additional experience with small molecules, monoclonal antibodies, or other modalities preferred. Hands-on expertise in PK/TK analysis, PKPD modeling, and study design. Knowledge of both non-regulated and regulated bioanalysis. Skills & Competencies Strong problem-solving skills with the ability to manage multiple projects in a fast-paced environment. Excellent communication skills, with the ability to present complex scientific data clearly to diverse audiences. Collaborative approach with the ability to work across disciplines to achieve program goals. Washington State Pay Range $132,274 - $159,338 USD Immunome, Inc. is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.
Immunome is a clinical-stage targeted oncology company committed to developing first-in-class and best-in-class targeted therapies designed to improve outcomes for cancer patients. We are advancing an innovative portfolio of therapeutics, drawing on leadership that previously played key roles in the design, development, and commercialization of cutting-edge targeted cancer therapies, including antibody-drug conjugate therapies (ADCs). Our most advanced pipeline programs are varegacestat (formerly AL102), a gamma secretase inhibitor which is currently in a Phase 3 trial for treatment of desmoid tumors; IM-1021, a ROR1-targeted ADC which is currently in a Phase 1 trial; and IM-3050, a FAP-targeted radioligand, which recently received IND clearance. Our pipeline also includes IM-1617, IM-1335, and IM-1340, all of which are preclinical ADCs pursuing undisclosed targets with expression in multiple solid tumors. The Scientist II, DMPK will contribute to the design and execution of nonclinical pharmacokinetics/ADME strategies to support oncology drug candidates from discovery through development. This role will partner closely with cross-functional teams to deliver high-quality data that informs decision-making and regulatory submissions. Reporting to the Executive Director, ADME, the Scientist II will work on multiple modalities, with a strong emphasis on ADC programs. Responsibilities Design and execute stage-appropriate DMPK/ADME studies to support candidate selection, clinical development, and regulatory submissions. Collaborate with cross-functional teams to ensure integration of DMPK considerations into program strategy and timelines. Analyze PK, TK, and PKPD data, perform modeling and simulation, and provide clear interpretation to inform program decisions. Participate in Translational Sciences and Development team activities, contributing scientific expertise in DMPK. Represent the ADME function at internal and external meetings, in collaboration with senior scientists, communicating timelines, data, and implications effectively. Maintain awareness of evolving best practices and regulatory expectations in DMPK sciences. Qualifications PhD in a relevant discipline with 02 years of industry experience in DMPK/ADME, or MS with 5+ years relevant industry experience. Experience with ADCs required; additional experience with small molecules, monoclonal antibodies, or other modalities preferred. Hands-on expertise in PK/TK analysis, PKPD modeling, and study design. Knowledge of both non-regulated and regulated bioanalysis. Skills & Competencies Strong problem-solving skills with the ability to manage multiple projects in a fast-paced environment. Excellent communication skills, with the ability to present complex scientific data clearly to diverse audiences. Collaborative approach with the ability to work across disciplines to achieve program goals. Washington State Pay Range $132,274 - $159,338 USD Immunome, Inc. is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.