Roswell Park
Senior Research Specialist - Bioinformatics Programmer
Roswell Park, Buffalo, New York, United States, 14201
Senior Research Specialist - Bioinformatics Programmer
Job Type:
Regular Company:
Health Research, Inc. (HRI) Roswell Park Division Department:
Molecular & Cellular Biology Time Type:
Full time Weekly Hours:
40 FTE:
1 Shift:
First Shift (United States of America) Summary:
The Koren lab at the Department of Molecular and Cellular Biology at Roswell Park Comprehensive Cancer Center uses genomic and computational approaches to study DNA replication timing and mutagenesis. The lab focuses on human populations and on comprehensive pan-cancer analyses, integrating additional large-scale genomics and epigenomics datasets. We develop methods for inferring DNA replication dynamics from whole genome sequence data, analyze the inter-relations between replication timing and epigenomic regulation, and understand the factors that affect mutation rates and patterns across normal and cancer genomes. More information is available at www.thekorenlab.org. The Bioinformatics Programmer will be involved in analyzing existing data related to population-level variation in DNA replication timing among humans, developing new pipelines for the inference of DNA replication timing along with DNA copy number from cancer genomes, applying those pipelines to thousands of cancer samples, and performing downstream cancer genomics analyses including mutation patterns. Qualifications: Required Education and Experience: 1. PhD and the equivalent of two (2) years of full-time professional research experience in a laboratory, clinical or scientific research environment; or 2. Master's degree and the equivalent of four (4) years of full-time professional research experience in a laboratory, clinical or scientific research environment; or 3. Bachelor's degree and the equivalent of six (6) years of full-time professional research experience in a laboratory, clinical or scientific research environment NOTE: Required degrees must have been granted by an accredited school, college or university or one recognized by Roswell Park Comprehensive Cancer Center as following acceptable educational practices. Preferred Qualifications: PhD or equivalent education plus experience in bioinformatics, genomics, genetics, computer science or related field Experience in human and/or cancer genomics and bioinformatics Experience with higher-level programming with relevant languages or platforms such as Matlab, R, python or similar Experience analyzing large-scale databases spanning thousands of samples in a computer cluster and/or cloud computing setting Ability to keep records, follow procedures, communicate effectively, and collaborate with others Equal Employment Opportunity Statement:
Roswell Park Cancer Institute Corporation (RPCIC) and Health Research Inc. (HRI) Roswell Park Division believe that all persons are entitled to equal employment opportunities, and we do not discriminate against our employees, applicants or job seekers because of their race, color, religion, sex, sexual orientation, gender identity or expression, national origin, creed, age, disability, pregnancy-related condition, military or veteran status, marital or familial status, domestic violence victim status, citizenship status, genetic information, individual's relationship or association with a member of a protected category or any other protected group status as defined by law. Our Core Values:
RPCIC and HRI are committed to providing an environment where patients, families, employees and community are treated with courtesy and respect. We support an inclusive environment that nurtures the talents, skills and abilities of each individual to embody and reflect our core values: Innovation, Integrity, Teamwork, Commitment, Compassion and Respect.
Job Type:
Regular Company:
Health Research, Inc. (HRI) Roswell Park Division Department:
Molecular & Cellular Biology Time Type:
Full time Weekly Hours:
40 FTE:
1 Shift:
First Shift (United States of America) Summary:
The Koren lab at the Department of Molecular and Cellular Biology at Roswell Park Comprehensive Cancer Center uses genomic and computational approaches to study DNA replication timing and mutagenesis. The lab focuses on human populations and on comprehensive pan-cancer analyses, integrating additional large-scale genomics and epigenomics datasets. We develop methods for inferring DNA replication dynamics from whole genome sequence data, analyze the inter-relations between replication timing and epigenomic regulation, and understand the factors that affect mutation rates and patterns across normal and cancer genomes. More information is available at www.thekorenlab.org. The Bioinformatics Programmer will be involved in analyzing existing data related to population-level variation in DNA replication timing among humans, developing new pipelines for the inference of DNA replication timing along with DNA copy number from cancer genomes, applying those pipelines to thousands of cancer samples, and performing downstream cancer genomics analyses including mutation patterns. Qualifications: Required Education and Experience: 1. PhD and the equivalent of two (2) years of full-time professional research experience in a laboratory, clinical or scientific research environment; or 2. Master's degree and the equivalent of four (4) years of full-time professional research experience in a laboratory, clinical or scientific research environment; or 3. Bachelor's degree and the equivalent of six (6) years of full-time professional research experience in a laboratory, clinical or scientific research environment NOTE: Required degrees must have been granted by an accredited school, college or university or one recognized by Roswell Park Comprehensive Cancer Center as following acceptable educational practices. Preferred Qualifications: PhD or equivalent education plus experience in bioinformatics, genomics, genetics, computer science or related field Experience in human and/or cancer genomics and bioinformatics Experience with higher-level programming with relevant languages or platforms such as Matlab, R, python or similar Experience analyzing large-scale databases spanning thousands of samples in a computer cluster and/or cloud computing setting Ability to keep records, follow procedures, communicate effectively, and collaborate with others Equal Employment Opportunity Statement:
Roswell Park Cancer Institute Corporation (RPCIC) and Health Research Inc. (HRI) Roswell Park Division believe that all persons are entitled to equal employment opportunities, and we do not discriminate against our employees, applicants or job seekers because of their race, color, religion, sex, sexual orientation, gender identity or expression, national origin, creed, age, disability, pregnancy-related condition, military or veteran status, marital or familial status, domestic violence victim status, citizenship status, genetic information, individual's relationship or association with a member of a protected category or any other protected group status as defined by law. Our Core Values:
RPCIC and HRI are committed to providing an environment where patients, families, employees and community are treated with courtesy and respect. We support an inclusive environment that nurtures the talents, skills and abilities of each individual to embody and reflect our core values: Innovation, Integrity, Teamwork, Commitment, Compassion and Respect.