Calyx
Scientist II, In Vivo Pharmacology, Oncology
Calyx, Needham, Massachusetts, United States, 02492
Scientist II
We are seeking a motivated and skilled Scientist II to support validation and execution of our imaging studies using preclinical in vivo oncology models. This role is central to our preclinical research team and involves building CDx and clinically relevant PDx platforms and hands-on work applying these models with nuclear medicine (PET/SPECT) and computed tomography (CT), MRI, Bioluminescence Imaging. The successful candidate will also provide technical support across a range of in vivo studies including efficacy, biodistribution, pharmacokinetics, tolerability, and dosimetry and ex vivo analysis of target tissues of relevance in oncology, Xenograft models. Key Responsibilities
Study Support & Execution Execute a wide range of study types including: Efficacy, biodistribution, pharmacokinetics, tolerability, and dosimetry. Experience with preclinical studies involving CDx or PDx models Experience with diverse tumor models including xenograft, subcutaneous, orthotopic, and syngeneic models Proficiency monitoring tumor volume, body weight, clinical signs and model-dependent humane endpoints Pharmacologic understanding of dosing levels and formulations Perform dosing and surgical procedures such as: Tumor induction in xenograft models (cell lines and tumor fragments implantation), Tumor tracking and measurement, IV, IP, SC, IM, PO administrations, Perfusion, tissue resection, microdissection, Biological sampling (blood, CSF, organs), Survival surgery and necropsy, Data analysis and interpretation, Abreast using ELN and in vivo databases and software tools for data recording and analysis. Assist in image acquisition (Bioluminescence, PET/SPECT, CT, MRI) and related procedures. Handle radioactive and BSL2 materials, including sample processing, gamma counting, and proper waste disposal. Ensure strict adherence to laboratory SOPs and regulatory guidelines (IACUC, radiation safety, lab safety). Scientific Communication & Process Improvement
Present study data to internal teams and sponsors. Prepare reports, slide decks, and summaries for senior leadership. Support regulatory and QA/QC inspections; ensure team readiness and documentation accuracy. Implement best practices and process enhancements (e.g., SOPs, automation tools). Stay abreast of emerging technologies and literature in cancer models, imaging, and in vivo techniques and effectively communicate priorities with the team. Functional Competencies (Technical knowledge/Skills) Hands-on experience with building in vivo oncology models, which could include subcutaneous xenograft, patient-derived xenograft (PDX), syngeneic, or humanized mouse models. Proficient in standard in vivo techniques (IV dosing, surgical procedures, sampling). Demonstrated experience in handling small animals, especially for oncology studies. Hands-on experience in a preclinical imaging environment. Microdissection of specific tissues (e.g., lymph nodes, brain sections). Ability to manage multiple projects and prioritize effectively. Behaviour Competencies Accountability Adaptability Customer focus Team player Willingness to learn Analytical thinking Experience, Education, and Certifications Bachelors degree in Biology, Animal Science, or related field with 10+ years of relevant in vivo research experience or advanced degree with 5+ years of relevant in vivo research experience. Prior experience with nuclear medicine will be considered a plus. Excellent multitasking, organizational, and time-management skills. Strong written and verbal communication abilities. Competence with computer systems and laboratory data platforms. Ability to lift up to 50 pounds. Availability to work occasional weekends as required.
We are seeking a motivated and skilled Scientist II to support validation and execution of our imaging studies using preclinical in vivo oncology models. This role is central to our preclinical research team and involves building CDx and clinically relevant PDx platforms and hands-on work applying these models with nuclear medicine (PET/SPECT) and computed tomography (CT), MRI, Bioluminescence Imaging. The successful candidate will also provide technical support across a range of in vivo studies including efficacy, biodistribution, pharmacokinetics, tolerability, and dosimetry and ex vivo analysis of target tissues of relevance in oncology, Xenograft models. Key Responsibilities
Study Support & Execution Execute a wide range of study types including: Efficacy, biodistribution, pharmacokinetics, tolerability, and dosimetry. Experience with preclinical studies involving CDx or PDx models Experience with diverse tumor models including xenograft, subcutaneous, orthotopic, and syngeneic models Proficiency monitoring tumor volume, body weight, clinical signs and model-dependent humane endpoints Pharmacologic understanding of dosing levels and formulations Perform dosing and surgical procedures such as: Tumor induction in xenograft models (cell lines and tumor fragments implantation), Tumor tracking and measurement, IV, IP, SC, IM, PO administrations, Perfusion, tissue resection, microdissection, Biological sampling (blood, CSF, organs), Survival surgery and necropsy, Data analysis and interpretation, Abreast using ELN and in vivo databases and software tools for data recording and analysis. Assist in image acquisition (Bioluminescence, PET/SPECT, CT, MRI) and related procedures. Handle radioactive and BSL2 materials, including sample processing, gamma counting, and proper waste disposal. Ensure strict adherence to laboratory SOPs and regulatory guidelines (IACUC, radiation safety, lab safety). Scientific Communication & Process Improvement
Present study data to internal teams and sponsors. Prepare reports, slide decks, and summaries for senior leadership. Support regulatory and QA/QC inspections; ensure team readiness and documentation accuracy. Implement best practices and process enhancements (e.g., SOPs, automation tools). Stay abreast of emerging technologies and literature in cancer models, imaging, and in vivo techniques and effectively communicate priorities with the team. Functional Competencies (Technical knowledge/Skills) Hands-on experience with building in vivo oncology models, which could include subcutaneous xenograft, patient-derived xenograft (PDX), syngeneic, or humanized mouse models. Proficient in standard in vivo techniques (IV dosing, surgical procedures, sampling). Demonstrated experience in handling small animals, especially for oncology studies. Hands-on experience in a preclinical imaging environment. Microdissection of specific tissues (e.g., lymph nodes, brain sections). Ability to manage multiple projects and prioritize effectively. Behaviour Competencies Accountability Adaptability Customer focus Team player Willingness to learn Analytical thinking Experience, Education, and Certifications Bachelors degree in Biology, Animal Science, or related field with 10+ years of relevant in vivo research experience or advanced degree with 5+ years of relevant in vivo research experience. Prior experience with nuclear medicine will be considered a plus. Excellent multitasking, organizational, and time-management skills. Strong written and verbal communication abilities. Competence with computer systems and laboratory data platforms. Ability to lift up to 50 pounds. Availability to work occasional weekends as required.