Pfizer
Overview
Associate Director, Pharmacometrician
role at
Pfizer . Use Your Power for Purpose. You will have a profound impact on improving patients' lives by ensuring our evidence is scientifically robust and providing unbiased, medically essential expertise. Your role connects sound scientific evidence with practical medical insights to enhance health and treatment outcomes, bridging data gaps and empowering healthcare decisions regarding the safe and appropriate use of medicines. In addition to professional challenge, we offer a culture that supports and encourages ideas, and recognizes individual contribution. Role Summary
Develops model informed drug development (MIDD) plans across projects and disease areas to optimize prospective studies, inform drug development strategy and project decision-making, in collaboration with partners. Conducts and reports quantitative analyses integrating pharmacokinetics, pharmacodynamics, patient characteristics, and disease states to optimize doses, dosage regimens and study designs throughout clinical drug development. Identifies opportunities where modeling and simulation can advance understanding of pharmacological activity, efficacy and safety. Support and/or develop pharmacometrics tools, automation workflows, software, and related business processes. Role Responsibilities
Provide support in the development of quantitative methodology, pharmacometrics tools, software, hardware, and related business processes. With guidance, provide MIDD expertise on multidisciplinary development teams, working closely with clinical pharmacologists, clinicians, and statisticians to create MIDD plans that include assessments of a drug’s efficacy, safety, and commercial viability. Plan and execute relevant quantitative analyses which may include population pharmacokinetics, pharmacokinetics/pharmacodynamics, exposure response, disease progression modeling, model-based meta-analysis, and decision analysis for multiple analyses supporting a program. Prepare formal presentations and written reports to Pfizer standards. Contribute to regulatory documents (summary documents, briefing books, regulatory responses). Maintain understanding of literature, government guidelines, and internal guidance related to pharmacometrics and MIDD. Contribute to the development or improvement of tools, processes, and methodology, including involvement in internal cross-functional workgroups, external alliances or committees, consortia and academic relationships. Basic Qualifications
PhD or equivalent degree with strong quantitative skills (e.g., pharmacometrics, pharmacokinetics, mechanistic modeling/systems pharmacology, statistics) 3+ years of experience in a quantitative field Expertise in analysis and programming software (e.g., Nonmem, R) Experience in pharmacometric analyses Good communication skills (written, oral) Drug development and/or regulatory experience Publications in relevant discipline Good understanding of Pharmacokinetics, Pharmacodynamics and Statistical Principles Demonstrated leadership capabilities including influencing and collaborating with peers, developing and coaching others, and guiding work to achieve outcomes and business impact. Preferred Qualifications
Experience using Nonmem, R and/or PsN software is preferred. Candidates from alternative backgrounds (e.g., mathematics, engineering, systems biology, medicine) will be considered if they can demonstrate relevant experience and expertise. We encourage applicants from different disciplines including clinical pharmacology, engineering, biostatistics, medicine, biology, etc. Organizational Relationships
Reports to Pharmacometrics Group Leader within the Pharmacometrics and Systems Pharmacology, TCS line organization. Matrixed relationships with Clinical Pharmacology Leads, Clinicians, Statisticians, and colleagues from Programming groups as required. Physical/Mental Requirements
Sitting; ability to perform complex data analyses. Work Location
Hybrid Compensation and Benefits
The annual base salary ranges from $135,100 to $225,100. Eligible for Pfizer’s Global Performance Plan with a target bonus of 17.5% of base salary and participation in our long-term incentive program. Benefits include 401(k) with Pfizer matching, retirement contributions, paid vacation/holiday/personal days, caregiver/parental and medical leave, and health benefits (medical, prescription, dental, vision). Salary ranges vary by location. Relocation assistance may be available based on business needs and eligibility. Learn more at Pfizer Candidate Site – U.S. Benefits. Sunshine Act
Pfizer may report payments and transfers of value to health care providers as required by law. If you are a licensed physician interviewed for this role, certain information may be reported to the government. Contact Talent Acquisition with questions. EEO & Employment Eligibility
Pfizer is an equal opportunity employer. We prohibit discrimination based on race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. We comply with applicable laws and require permanent work authorization in the United States (E-Verify). For accessibility assistance, contact disabilityrecruitment@pfizer.com. Seniority level: Mid-Senior level Employment type: Full-time Job function: Business Development and Sales; Industries: Pharmaceutical Manufacturing
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Associate Director, Pharmacometrician
role at
Pfizer . Use Your Power for Purpose. You will have a profound impact on improving patients' lives by ensuring our evidence is scientifically robust and providing unbiased, medically essential expertise. Your role connects sound scientific evidence with practical medical insights to enhance health and treatment outcomes, bridging data gaps and empowering healthcare decisions regarding the safe and appropriate use of medicines. In addition to professional challenge, we offer a culture that supports and encourages ideas, and recognizes individual contribution. Role Summary
Develops model informed drug development (MIDD) plans across projects and disease areas to optimize prospective studies, inform drug development strategy and project decision-making, in collaboration with partners. Conducts and reports quantitative analyses integrating pharmacokinetics, pharmacodynamics, patient characteristics, and disease states to optimize doses, dosage regimens and study designs throughout clinical drug development. Identifies opportunities where modeling and simulation can advance understanding of pharmacological activity, efficacy and safety. Support and/or develop pharmacometrics tools, automation workflows, software, and related business processes. Role Responsibilities
Provide support in the development of quantitative methodology, pharmacometrics tools, software, hardware, and related business processes. With guidance, provide MIDD expertise on multidisciplinary development teams, working closely with clinical pharmacologists, clinicians, and statisticians to create MIDD plans that include assessments of a drug’s efficacy, safety, and commercial viability. Plan and execute relevant quantitative analyses which may include population pharmacokinetics, pharmacokinetics/pharmacodynamics, exposure response, disease progression modeling, model-based meta-analysis, and decision analysis for multiple analyses supporting a program. Prepare formal presentations and written reports to Pfizer standards. Contribute to regulatory documents (summary documents, briefing books, regulatory responses). Maintain understanding of literature, government guidelines, and internal guidance related to pharmacometrics and MIDD. Contribute to the development or improvement of tools, processes, and methodology, including involvement in internal cross-functional workgroups, external alliances or committees, consortia and academic relationships. Basic Qualifications
PhD or equivalent degree with strong quantitative skills (e.g., pharmacometrics, pharmacokinetics, mechanistic modeling/systems pharmacology, statistics) 3+ years of experience in a quantitative field Expertise in analysis and programming software (e.g., Nonmem, R) Experience in pharmacometric analyses Good communication skills (written, oral) Drug development and/or regulatory experience Publications in relevant discipline Good understanding of Pharmacokinetics, Pharmacodynamics and Statistical Principles Demonstrated leadership capabilities including influencing and collaborating with peers, developing and coaching others, and guiding work to achieve outcomes and business impact. Preferred Qualifications
Experience using Nonmem, R and/or PsN software is preferred. Candidates from alternative backgrounds (e.g., mathematics, engineering, systems biology, medicine) will be considered if they can demonstrate relevant experience and expertise. We encourage applicants from different disciplines including clinical pharmacology, engineering, biostatistics, medicine, biology, etc. Organizational Relationships
Reports to Pharmacometrics Group Leader within the Pharmacometrics and Systems Pharmacology, TCS line organization. Matrixed relationships with Clinical Pharmacology Leads, Clinicians, Statisticians, and colleagues from Programming groups as required. Physical/Mental Requirements
Sitting; ability to perform complex data analyses. Work Location
Hybrid Compensation and Benefits
The annual base salary ranges from $135,100 to $225,100. Eligible for Pfizer’s Global Performance Plan with a target bonus of 17.5% of base salary and participation in our long-term incentive program. Benefits include 401(k) with Pfizer matching, retirement contributions, paid vacation/holiday/personal days, caregiver/parental and medical leave, and health benefits (medical, prescription, dental, vision). Salary ranges vary by location. Relocation assistance may be available based on business needs and eligibility. Learn more at Pfizer Candidate Site – U.S. Benefits. Sunshine Act
Pfizer may report payments and transfers of value to health care providers as required by law. If you are a licensed physician interviewed for this role, certain information may be reported to the government. Contact Talent Acquisition with questions. EEO & Employment Eligibility
Pfizer is an equal opportunity employer. We prohibit discrimination based on race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. We comply with applicable laws and require permanent work authorization in the United States (E-Verify). For accessibility assistance, contact disabilityrecruitment@pfizer.com. Seniority level: Mid-Senior level Employment type: Full-time Job function: Business Development and Sales; Industries: Pharmaceutical Manufacturing
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