Shennon Biotechnologies
Scientist / Senior Scientist - TCR engineering and TCE development
Shennon Biotechnologies, San Francisco, California, United States, 94199
Overview
We are a well-funded biotech startup that has developed a suite of proprietary technologies combining ultrahigh throughput single cell functional screening with computational AI models to advance immunotherapies for cancer and autoimmune diseases. We are looking for a protein engineering scientist with experience in TCR affinity maturation and T cell engager (TCE) development to join our interdisciplinary team. The candidate should adapt quickly and communicate well in a fast-paced startup environment and collaborate with other team members. Responsibilities
Design libraries and perform TCR affinity maturation using yeast or phage display. Lead TCR engineering efforts for enhanced affinity, specificity, and stability. Partner with AI/ML scientists to design sequences and libraries, contributing to iterative design-build-test cycles to advance therapeutic candidates. Collaborate with the team to develop TCEs and conduct in vitro functional assays to assess efficacy and safety. Work with CRO on TCR/TCE production and binding characterization. Skills and Qualifications
PhD in Biochemistry, Molecular Biology, Bioengineering, Immunology, or a related field. Expertise in display technologies (yeast or phage), and high-throughput TCR/antibody screening. Experience in TCR, antibody or protein engineering, including affinity maturation, deep mutational scanning, cross-reactivity, and biophysical property optimization. Experience with TCR/antibody library construction, screening, and binding measurement. Fundamental understanding of TCR/antibody and structure-function relationships. Familiarity with protein structure analysis tools (PyMOL, Chimera, MOE). Ability to work in a fast-paced startup environment, take initiative, and drive projects forward independently. Excellent communication and collaboration skills. Preferred Qualifications
Experience with bispecific antibodies and format screening. Background in T Cell Engager development. Experience with mammalian expression systems and protein purification techniques. Compensation and Benefits
$120,000 - $160,000 (depending on depth of expertise) + 10% performance bonus + equity. 4% 401K match; Daily lunches; Commuter benefits; Unlimited snacks and drinks. Disability Insurance, Life Insurance; Workplace Insurance.
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We are a well-funded biotech startup that has developed a suite of proprietary technologies combining ultrahigh throughput single cell functional screening with computational AI models to advance immunotherapies for cancer and autoimmune diseases. We are looking for a protein engineering scientist with experience in TCR affinity maturation and T cell engager (TCE) development to join our interdisciplinary team. The candidate should adapt quickly and communicate well in a fast-paced startup environment and collaborate with other team members. Responsibilities
Design libraries and perform TCR affinity maturation using yeast or phage display. Lead TCR engineering efforts for enhanced affinity, specificity, and stability. Partner with AI/ML scientists to design sequences and libraries, contributing to iterative design-build-test cycles to advance therapeutic candidates. Collaborate with the team to develop TCEs and conduct in vitro functional assays to assess efficacy and safety. Work with CRO on TCR/TCE production and binding characterization. Skills and Qualifications
PhD in Biochemistry, Molecular Biology, Bioengineering, Immunology, or a related field. Expertise in display technologies (yeast or phage), and high-throughput TCR/antibody screening. Experience in TCR, antibody or protein engineering, including affinity maturation, deep mutational scanning, cross-reactivity, and biophysical property optimization. Experience with TCR/antibody library construction, screening, and binding measurement. Fundamental understanding of TCR/antibody and structure-function relationships. Familiarity with protein structure analysis tools (PyMOL, Chimera, MOE). Ability to work in a fast-paced startup environment, take initiative, and drive projects forward independently. Excellent communication and collaboration skills. Preferred Qualifications
Experience with bispecific antibodies and format screening. Background in T Cell Engager development. Experience with mammalian expression systems and protein purification techniques. Compensation and Benefits
$120,000 - $160,000 (depending on depth of expertise) + 10% performance bonus + equity. 4% 401K match; Daily lunches; Commuter benefits; Unlimited snacks and drinks. Disability Insurance, Life Insurance; Workplace Insurance.
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