GSK LLP
Executive Medical Director Translational Medicine Group Leader - Respiratory
GSK LLP, Watertown, Massachusetts, us, 02472
Overview
Executive Medical Director Translational Medicine Group Leader - Respiratory at GSK. Location options include USA (Pennsylvania, Upper Providence/Collegeville), UK (Hertfordshire/Stevenage, London New Oxford Street), with on-site presence 2 to 3 days a week. Are you an industry pulmonologist seeking to bridge respiratory preclinical research and clinical development? This role leads efforts to transition innovative therapeutics from the laboratory to Proof of Mechanism/Clinical Activity in the clinic and reports to the SVP Head Early Pipeline Unit. Key Responsibilities
Provide disease-level leadership to develop causal maps of pathobiology and translational tools/endpoints/biomarkers to enable timely experimentation and derisk programmes. Strategic leadership for design, execution, and management of clinical development plans and clinical trials for Early Pipeline Unit programmes. Provide translational and clinical leadership in defining and executing innovative early development strategies; ensure clinical study designs align with the IEP and CDP, considering scientific rationale, regulatory requirements, product development plan, and commercial goals. Stay abreast of advancements in TA research, trial methodologies, and regulatory changes to maintain GSKs competitive edge. Contribute to regulatory interactions, including briefing documents, presentations, and responses. Contribute to Business Development activities, including due diligence projects. Champion translational and biomarker strategies across therapeutic areas. DAAT Leadership
Lead the Disease Area Acceleration Team (DAAT), aligning scientific and clinical strategies with business objectives through matrix leadership of cross-functional teams. Drive evaluation of therapeutic potential and clinical tractability of targets within the disease area. Identify transformational opportunities where projects offer significant patient benefits. Program Delivery
Ensure quality, on-time, and on-budget delivery of studies and programmes within a therapeutic area of the Early Pipeline Unit. Design and implement experimental medicine studies. Oversee risk assessment across programs and implement mitigation strategies. Line Management, Collaboration and Matrix Working
Manage, mentor and coach early Clinical Development Leads to foster empowerment, innovation and excellence. Collaborate with cross-functional teams across Advance Pipeline Unit, Commercial, Research Tech and Development organisations. Build and maintain networks with internal and external stakeholders, including academic institutions, CROs, and regulators. Represent GSK effectively in external collaborations and negotiations. Problem Solving and Decision Making
Anticipate challenges and proactively develop risk-mitigation strategies. Make decisions balancing risk/benefit with clear impact assessment. Written and Oral Communication: Lead the writing and review of study-related documents and regulatory submissions; communicate confidently at all levels. Ways of Working
Champion innovative business processes and strategies to improve clinical development outcomes. Qualifications
Basic Requirements:
Physician scientist with board qualification/registration in Pulmonary Medicine. Strong industry experience in respiratory clinical drug development. Thorough understanding of respiratory therapy area, biology, and potential targets. Experience planning clinical development for a respiratory asset/indication. Significant respiratory clinical trials and projects experience, including deriving causal confidence from novel sources or qualifying novel endpoints. Experience in translational medicine, clinical research methodology, and biostatistics to enable innovative and efficient trial designs with data-driven decision rules. Strong leadership experience including direct line management, coaching, mentoring, and team development. Preferred Qualifications/Experience
In addition to Pulmonologist credentials, hold a higher research degree (e.g., PhD) or demonstrable research expertise (e.g., faculty appointments). Experience collaborating with multiple stakeholders on complex projects and building strong relationships with internal and external partners. Extensive network with thought leaders, institutions, and consortia in respiratory medicine. GSK is an Equal Opportunity Employer. If you require accommodation to apply, contact the GSK Service Centre. #J-18808-Ljbffr
Executive Medical Director Translational Medicine Group Leader - Respiratory at GSK. Location options include USA (Pennsylvania, Upper Providence/Collegeville), UK (Hertfordshire/Stevenage, London New Oxford Street), with on-site presence 2 to 3 days a week. Are you an industry pulmonologist seeking to bridge respiratory preclinical research and clinical development? This role leads efforts to transition innovative therapeutics from the laboratory to Proof of Mechanism/Clinical Activity in the clinic and reports to the SVP Head Early Pipeline Unit. Key Responsibilities
Provide disease-level leadership to develop causal maps of pathobiology and translational tools/endpoints/biomarkers to enable timely experimentation and derisk programmes. Strategic leadership for design, execution, and management of clinical development plans and clinical trials for Early Pipeline Unit programmes. Provide translational and clinical leadership in defining and executing innovative early development strategies; ensure clinical study designs align with the IEP and CDP, considering scientific rationale, regulatory requirements, product development plan, and commercial goals. Stay abreast of advancements in TA research, trial methodologies, and regulatory changes to maintain GSKs competitive edge. Contribute to regulatory interactions, including briefing documents, presentations, and responses. Contribute to Business Development activities, including due diligence projects. Champion translational and biomarker strategies across therapeutic areas. DAAT Leadership
Lead the Disease Area Acceleration Team (DAAT), aligning scientific and clinical strategies with business objectives through matrix leadership of cross-functional teams. Drive evaluation of therapeutic potential and clinical tractability of targets within the disease area. Identify transformational opportunities where projects offer significant patient benefits. Program Delivery
Ensure quality, on-time, and on-budget delivery of studies and programmes within a therapeutic area of the Early Pipeline Unit. Design and implement experimental medicine studies. Oversee risk assessment across programs and implement mitigation strategies. Line Management, Collaboration and Matrix Working
Manage, mentor and coach early Clinical Development Leads to foster empowerment, innovation and excellence. Collaborate with cross-functional teams across Advance Pipeline Unit, Commercial, Research Tech and Development organisations. Build and maintain networks with internal and external stakeholders, including academic institutions, CROs, and regulators. Represent GSK effectively in external collaborations and negotiations. Problem Solving and Decision Making
Anticipate challenges and proactively develop risk-mitigation strategies. Make decisions balancing risk/benefit with clear impact assessment. Written and Oral Communication: Lead the writing and review of study-related documents and regulatory submissions; communicate confidently at all levels. Ways of Working
Champion innovative business processes and strategies to improve clinical development outcomes. Qualifications
Basic Requirements:
Physician scientist with board qualification/registration in Pulmonary Medicine. Strong industry experience in respiratory clinical drug development. Thorough understanding of respiratory therapy area, biology, and potential targets. Experience planning clinical development for a respiratory asset/indication. Significant respiratory clinical trials and projects experience, including deriving causal confidence from novel sources or qualifying novel endpoints. Experience in translational medicine, clinical research methodology, and biostatistics to enable innovative and efficient trial designs with data-driven decision rules. Strong leadership experience including direct line management, coaching, mentoring, and team development. Preferred Qualifications/Experience
In addition to Pulmonologist credentials, hold a higher research degree (e.g., PhD) or demonstrable research expertise (e.g., faculty appointments). Experience collaborating with multiple stakeholders on complex projects and building strong relationships with internal and external partners. Extensive network with thought leaders, institutions, and consortia in respiratory medicine. GSK is an Equal Opportunity Employer. If you require accommodation to apply, contact the GSK Service Centre. #J-18808-Ljbffr