ZipRecruiter
Key Responsibilities
30% Operating LC-MS systems to perform in-process and final QC of various scales of highly modified oligonucleotides, including siRNA and ASO, to support both discovery portfolio and pre-portfolio projects
20% Optimize methods and improve analytical capabilities for Client Oligonucleotide synthesis
10% Analyze and optimize methods in a project-specific way (i.e. GalNAc vs Cholesterol vs C16) by denaturing and non-denaturing HPLC methods. In addition, phosphoramidites or lipids by HPLC and LCMS.
20% Establish and automate high throughput analytical capabilities and coordinate those efforts with higher synthesis throughput.
5% Analyze oligonucleotides by HPLC-SEC, RP-IP and Ion-Exchange Chromatography.
Continue optimizing siRNAs using best-in class analytical chemistry methodologies such as different column matrices for optimal siRNA characterization
Support integrity confirmation requests (such as concentration) by assay development and biology teams
3% Conduct QC for lipid nanoparticle (LNP) formulations of mRNA
5% Ensure the supply of laboratory consumables and reagents are in stock as needed
Maintain a high level of productivity in the laboratory setting.
2% Present data and reports on project status at individual, group, and departmental meetings.
Qualifications
Ph.D. with 1-3 years of experience, performing progressively advanced duties at the Scientist level, or the equivalent training/experience is required.
Prior experience in the characterization of oligonucleotides and/or nucleoside/nucleotide analytes is required.
The position requires onsite work 100% (no negotiations).
Must be able to commute to work every day
PhD is required
Must have experience with Analytical Chemistry
Must have experience with Oligonucleotides
Must have siRNA experience
Previous gene therapy experience
Experience with Chromatography (LC-MS)
Experience with instruments such as Thermo LTQ, LC/MS or Thermo Orbitrap LC/MS
Top three skills: Operate LC-MS systems; Analyze and optimize methods; establish and automate high throughput analytical capabilities
Role is 100% onsite
About US Tech Solutions US Tech Solutions is a global staff augmentation firm providing a wide range of talent on-demand and total workforce solutions. To know more about US Tech Solutions, please visit www.ustechsolutions.com
US Tech Solutions is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, veteran status, or other protected status.
Recruiter Details Name: I.Prudvi kumar
Email: prudvi.k@ustechsolutionsinc.com
Internal Id: 25-47150
#J-18808-Ljbffr
30% Operating LC-MS systems to perform in-process and final QC of various scales of highly modified oligonucleotides, including siRNA and ASO, to support both discovery portfolio and pre-portfolio projects
20% Optimize methods and improve analytical capabilities for Client Oligonucleotide synthesis
10% Analyze and optimize methods in a project-specific way (i.e. GalNAc vs Cholesterol vs C16) by denaturing and non-denaturing HPLC methods. In addition, phosphoramidites or lipids by HPLC and LCMS.
20% Establish and automate high throughput analytical capabilities and coordinate those efforts with higher synthesis throughput.
5% Analyze oligonucleotides by HPLC-SEC, RP-IP and Ion-Exchange Chromatography.
Continue optimizing siRNAs using best-in class analytical chemistry methodologies such as different column matrices for optimal siRNA characterization
Support integrity confirmation requests (such as concentration) by assay development and biology teams
3% Conduct QC for lipid nanoparticle (LNP) formulations of mRNA
5% Ensure the supply of laboratory consumables and reagents are in stock as needed
Maintain a high level of productivity in the laboratory setting.
2% Present data and reports on project status at individual, group, and departmental meetings.
Qualifications
Ph.D. with 1-3 years of experience, performing progressively advanced duties at the Scientist level, or the equivalent training/experience is required.
Prior experience in the characterization of oligonucleotides and/or nucleoside/nucleotide analytes is required.
The position requires onsite work 100% (no negotiations).
Must be able to commute to work every day
PhD is required
Must have experience with Analytical Chemistry
Must have experience with Oligonucleotides
Must have siRNA experience
Previous gene therapy experience
Experience with Chromatography (LC-MS)
Experience with instruments such as Thermo LTQ, LC/MS or Thermo Orbitrap LC/MS
Top three skills: Operate LC-MS systems; Analyze and optimize methods; establish and automate high throughput analytical capabilities
Role is 100% onsite
About US Tech Solutions US Tech Solutions is a global staff augmentation firm providing a wide range of talent on-demand and total workforce solutions. To know more about US Tech Solutions, please visit www.ustechsolutions.com
US Tech Solutions is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, veteran status, or other protected status.
Recruiter Details Name: I.Prudvi kumar
Email: prudvi.k@ustechsolutionsinc.com
Internal Id: 25-47150
#J-18808-Ljbffr