eTeam
Overview
Job Title:
Scientist I, Oligonucleotide Analytics Company: eTeam Duration: 12 Months Pay Range:
$52.64/hr - $55.00/hr
on W2 all-inclusive without benefits Hybrid: 3 days onsite, 2 days remote Note: This listing includes initial base pay information and recruiter-delivered details. The final compensation will be discussed with the recruiter. Responsibilities
Operate LC-MS systems to perform in-process and final QC of various scales of highly modified oligonucleotides, including siRNA and ASO, to support both discovery portfolio and pre-portfolio projects. Optimize methods and improve analytical capabilities for novel Oligonucleotide synthesis. Analyze and optimize methods in a project-specific way (e.g., GalNAc vs Cholesterol vs C16) by denaturing and non-denaturing HPLC methods. Work with phosphoramidites or lipids by HPLC and LCMS. Establish and automate high throughput analytical capabilities and coordinate those efforts with higher synthesis throughput. Analyze oligonucleotides by HPLC-SEC, RP-IP and Ion-Exchange Chromatography. Continue optimizing siRNAs using best-in-class analytical chemistry methodologies, including different column matrices for optimal siRNA characterization. Support integrity confirmation requests (such as concentration) by assay development and biology teams. Conduct QC for lipid nanoparticle (LNP) formulations of mRNA. Ensure the supply of laboratory consumables and reagents are in stock as needed. Maintain a high level of productivity in the laboratory setting. Present data and reports on project status at individual, group, and departmental meetings. Qualifications
Ph.D. with 1-3 years of experience, performing progressively advanced duties at the Scientist level, or the equivalent training/experience, is required. Prior experience in the characterization of oligonucleotides and/or nucleoside/nucleotide analytes is required. Top Three Skills: Operate LC-MS systems; Analyze and optimize methods; establish and automate high throughput analytical capabilities. Seniority level
Not Applicable Employment type
Contract Job function
Science and Research Industries
Biotechnology Research and Pharmaceutical Manufacturing
#J-18808-Ljbffr
Job Title:
Scientist I, Oligonucleotide Analytics Company: eTeam Duration: 12 Months Pay Range:
$52.64/hr - $55.00/hr
on W2 all-inclusive without benefits Hybrid: 3 days onsite, 2 days remote Note: This listing includes initial base pay information and recruiter-delivered details. The final compensation will be discussed with the recruiter. Responsibilities
Operate LC-MS systems to perform in-process and final QC of various scales of highly modified oligonucleotides, including siRNA and ASO, to support both discovery portfolio and pre-portfolio projects. Optimize methods and improve analytical capabilities for novel Oligonucleotide synthesis. Analyze and optimize methods in a project-specific way (e.g., GalNAc vs Cholesterol vs C16) by denaturing and non-denaturing HPLC methods. Work with phosphoramidites or lipids by HPLC and LCMS. Establish and automate high throughput analytical capabilities and coordinate those efforts with higher synthesis throughput. Analyze oligonucleotides by HPLC-SEC, RP-IP and Ion-Exchange Chromatography. Continue optimizing siRNAs using best-in-class analytical chemistry methodologies, including different column matrices for optimal siRNA characterization. Support integrity confirmation requests (such as concentration) by assay development and biology teams. Conduct QC for lipid nanoparticle (LNP) formulations of mRNA. Ensure the supply of laboratory consumables and reagents are in stock as needed. Maintain a high level of productivity in the laboratory setting. Present data and reports on project status at individual, group, and departmental meetings. Qualifications
Ph.D. with 1-3 years of experience, performing progressively advanced duties at the Scientist level, or the equivalent training/experience, is required. Prior experience in the characterization of oligonucleotides and/or nucleoside/nucleotide analytes is required. Top Three Skills: Operate LC-MS systems; Analyze and optimize methods; establish and automate high throughput analytical capabilities. Seniority level
Not Applicable Employment type
Contract Job function
Science and Research Industries
Biotechnology Research and Pharmaceutical Manufacturing
#J-18808-Ljbffr