SciPro
Overview
Job Title:
Associate Director / Director, Medicinal Chemistry (Small Molecules) Location:
Cambridge, MA Industry:
Commercial-Stage Pharmaceutical Company Employment Type:
Full-Time About the Role
A commercially successful, innovation-driven pharmaceutical company based in Cambridge, MA is seeking an Associate Director/Director in Medicinal Chemistry to join their growing small molecule drug discovery team. This is a high-impact role offering the opportunity to lead early- and late-stage discovery programs with direct visibility to senior leadership. The ideal candidate will bring deep synthetic and medicinal chemistry expertise, strategic leadership, and a successful track record of drug discovery in large pharma environments. Key Responsibilities
Lead cross-functional medicinal chemistry efforts from hit generation through candidate nomination and into preclinical development. Design and execute synthetic strategies to optimize potency, selectivity, PK, and safety of small molecule drug candidates. Partner closely with DMPK, biology, structural biology, and computational chemistry to guide SAR and compound profiling. Mentor and manage internal scientists and external CRO resources. Contribute to portfolio strategy and shape the future of the small molecule pipeline. Communicate data and strategy effectively to stakeholders across discovery, development, and executive leadership. Qualifications
Ph.D. in Organic or Medicinal Chemistry with 10+ years of industry experience in small molecule drug discovery. Proven success advancing programs to development candidate stage, ideally through IND-enabling studies. Current or recent experience in large pharma is required Deep understanding of structure-based drug design, SAR development, and synthetic optimization. Demonstrated leadership and project ownership in multidisciplinary team settings. Strong communication, strategic thinking, and mentoring capabilities.
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Job Title:
Associate Director / Director, Medicinal Chemistry (Small Molecules) Location:
Cambridge, MA Industry:
Commercial-Stage Pharmaceutical Company Employment Type:
Full-Time About the Role
A commercially successful, innovation-driven pharmaceutical company based in Cambridge, MA is seeking an Associate Director/Director in Medicinal Chemistry to join their growing small molecule drug discovery team. This is a high-impact role offering the opportunity to lead early- and late-stage discovery programs with direct visibility to senior leadership. The ideal candidate will bring deep synthetic and medicinal chemistry expertise, strategic leadership, and a successful track record of drug discovery in large pharma environments. Key Responsibilities
Lead cross-functional medicinal chemistry efforts from hit generation through candidate nomination and into preclinical development. Design and execute synthetic strategies to optimize potency, selectivity, PK, and safety of small molecule drug candidates. Partner closely with DMPK, biology, structural biology, and computational chemistry to guide SAR and compound profiling. Mentor and manage internal scientists and external CRO resources. Contribute to portfolio strategy and shape the future of the small molecule pipeline. Communicate data and strategy effectively to stakeholders across discovery, development, and executive leadership. Qualifications
Ph.D. in Organic or Medicinal Chemistry with 10+ years of industry experience in small molecule drug discovery. Proven success advancing programs to development candidate stage, ideally through IND-enabling studies. Current or recent experience in large pharma is required Deep understanding of structure-based drug design, SAR development, and synthetic optimization. Demonstrated leadership and project ownership in multidisciplinary team settings. Strong communication, strategic thinking, and mentoring capabilities.
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