Global Life Science Hub is hiring: Manufacturing Supervisor in Chicago

Overview

Global Life Science Hub is partnered with a fast-moving biologics biotech that is scaling production. We’re seeking a Manufacturing Supervisor to lead the 2nd shift Drug Substance operations on-site in Chicago.

The appointed candidate will play a critical role in managing the production activities for Biologics Manufacturing for the 2nd shift operation. This includes supervising cell culture fermentation, protein purification, and aseptic processing to produce high-quality drug substances.

Responsibilities

• Lead and supervise daily production activities in compliance with cGMPs, SOPs, and Environmental Health and Safety (EHS) guidelines.
• Oversee E. coli cell culture fermentation, centrifugation, and homogenization processes.
• Manage protein purification using chromatography columns and various filtration systems.
• Ensure successful formulation, aseptic filtration, and visual inspection of drug product syringes.
• Coordinate the preparation, washing, and sterilization of machine parts and materials for aseptic processing areas.
• Report production status and progress to supervisors and other departments.
• Coordinate production batch scheduling with management, adjusting schedules as necessary to meet production needs and timelines.
• Implement organizational systems to efficiently allocate workload, maintain compliance, and improve productivity across shifts.
• Train employees on cleanroom behavior, equipment operation, and detailed process instructions.
• Develop and maintain comprehensive training materials and ensure staff remain up-to-date on operational protocols and compliance requirements.
• Author and revise Batch Records, Standard Operating Procedures (SOPs), and other production documentation to integrate cGMPs and optimize process efficiency.
• Ensure all manufacturing activities adhere to internal and external regulatory standards, supporting audits and inspections as needed.
• Participate in the qualification of drug product manufacturing suites, ensuring successful validation and qualification batch execution.
• Procure necessary materials and supplies with a focus on cost reduction and resource management.
• Track and manage inventory to support continuous production flow, while identifying and implementing strategies to minimize waste and reduce material costs.
• Identify opportunities for efficiency improvements and lead initiatives to enhance process performance.
• Implement best practices and support continuous improvement in production quality and throughput.

Experience/Qualifications

• Bachelor’s degree in Biotechnology, Biochemistry, Microbiology, Chemical Engineering, or a related field.
• Minimum 3-5 years in biologics or biopharmaceutical manufacturing, with expertise in cell culture, fermentation, and protein purification.
• Hands-on experience with aseptic processing and equipment preparation.
• Prior experience supervising or coordinating manufacturing teams within a cGMP environment.

Seniority level

• Mid-Senior level

Employment type

• Full-time

Job function

• Manufacturing

Industries

• Pharmaceutical Manufacturing and Biotechnology Research