Generalproximity
Scientist/Sr. Scientist, Chemical Biology
Generalproximity, San Francisco, California, United States, 94199
Overview
General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs). Our OmniTAC drug discovery engine furnishes molecules that co-op existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades. We are seeking a first-rate chemical biologist to help us pioneer this uncharted frontier of drug discovery. The Position
We are seeking an
experienced chemical biologist with medicinal chemistry training to be a founding member of our Chemistry/Drug Discovery Team . In this position, you will work with both our Chemistry and Platform Teams in the development of our core drug discovery technology and the generation of a completely novel class of therapeutics. Your responsibilities will include: Supervising synthetic efforts with our CROs Designing, performing, and analyzing in cellulo assays Designing and optimizing first-in-class bifunctional molecules Collaborating with our Drug Discovery and IP team on patent applications Providing input for mechanistic studies on lead drug molecules Spearheading forays into new disease areas About You
High Agency.
Initiative, independence, and self-accountability are some of our most valued traits. Enthusiastic.
We love people who are excited about what they are doing and are generally attempting to build a high-energy team. Intensity and Grit.
Early-stage startups are hard. Drug discovery is doubly so. We are looking for candidates who have a demonstrated ability to stick with complex problems for the long haul, with a team that has your back along the way. Prosocial.
We are here to create life-saving medicines for the patients who need it most. You should be, too. Qualifications & Nice-To-Haves
PhD in Chemical Biology, Medicinal Chemistry, Pharmacology, or related field. Industry experience is desirable, but the ability to work hard and learn fast is more important to us. Deep understanding of small-molecule drug discovery and its relationship to human disease. Able to work fluently at the interface of chemistry and biology. Top-notch written and oral communication skills. Strong experience with:
Designing, synthesizing, and optimizing induced proximity medicines (e.g. PROTACs or other IPMs) Contributing to hit-to-lead and lead optimization studies Med-chem optimizations: SAR, PK/PD, strong understanding of DMPK Experience with chemical biology techniques such as mammalian cell culture and cell-based assays (e.g., cytotoxicity assays, transfections, stable cell line generation, co-immunoprecipitation), and PPI assays (e.g., BRET, APEX/BioID, AlphaScreen)
Nice to have:
Proficiency in HTS and phenotypic assay development Proteomics experience: PTM analysis, chemo-proteomic target deconvolution, etc. Computational or molecular dynamics drug discovery experience DEL experience Experience managing others, especially synthetic chemistry CRO teams Prior experience on teams that have successfully advanced research to the clinic
About Us
Work Hard/Play Hard.
We believe time is our most valuable commodity, so we strive to create a culture that reflects this. We won’t drag you through unnecessary meetings or email you at 7 PM on a Saturday. When we\'re at work, we\'re there to get things done, and when we\'re off, we\'re really off. Strong Communication.
We like well-written documents over PowerPoints, OKRs over vague mission statements, and weekly one-on-ones over yearly reviews. Writing First.
We have a "writing-first" culture. We believe that clarity of writing reflects clarity of thinking and that the benefits of well-written documentation in a scientific environment are innumerable: democratization of ideation and decision-making, increased reproducibility, quicker scaling and onboarding, and better company-wide alignment, to name a few. Growth.
As an early-stage startup, we value scientists with an independent, can-do attitude. The more hats you can wear, the better. Our job as employers is to put you in positive feedback loops so you can grow in the direction of your choosing.
#J-18808-Ljbffr
General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs). Our OmniTAC drug discovery engine furnishes molecules that co-op existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades. We are seeking a first-rate chemical biologist to help us pioneer this uncharted frontier of drug discovery. The Position
We are seeking an
experienced chemical biologist with medicinal chemistry training to be a founding member of our Chemistry/Drug Discovery Team . In this position, you will work with both our Chemistry and Platform Teams in the development of our core drug discovery technology and the generation of a completely novel class of therapeutics. Your responsibilities will include: Supervising synthetic efforts with our CROs Designing, performing, and analyzing in cellulo assays Designing and optimizing first-in-class bifunctional molecules Collaborating with our Drug Discovery and IP team on patent applications Providing input for mechanistic studies on lead drug molecules Spearheading forays into new disease areas About You
High Agency.
Initiative, independence, and self-accountability are some of our most valued traits. Enthusiastic.
We love people who are excited about what they are doing and are generally attempting to build a high-energy team. Intensity and Grit.
Early-stage startups are hard. Drug discovery is doubly so. We are looking for candidates who have a demonstrated ability to stick with complex problems for the long haul, with a team that has your back along the way. Prosocial.
We are here to create life-saving medicines for the patients who need it most. You should be, too. Qualifications & Nice-To-Haves
PhD in Chemical Biology, Medicinal Chemistry, Pharmacology, or related field. Industry experience is desirable, but the ability to work hard and learn fast is more important to us. Deep understanding of small-molecule drug discovery and its relationship to human disease. Able to work fluently at the interface of chemistry and biology. Top-notch written and oral communication skills. Strong experience with:
Designing, synthesizing, and optimizing induced proximity medicines (e.g. PROTACs or other IPMs) Contributing to hit-to-lead and lead optimization studies Med-chem optimizations: SAR, PK/PD, strong understanding of DMPK Experience with chemical biology techniques such as mammalian cell culture and cell-based assays (e.g., cytotoxicity assays, transfections, stable cell line generation, co-immunoprecipitation), and PPI assays (e.g., BRET, APEX/BioID, AlphaScreen)
Nice to have:
Proficiency in HTS and phenotypic assay development Proteomics experience: PTM analysis, chemo-proteomic target deconvolution, etc. Computational or molecular dynamics drug discovery experience DEL experience Experience managing others, especially synthetic chemistry CRO teams Prior experience on teams that have successfully advanced research to the clinic
About Us
Work Hard/Play Hard.
We believe time is our most valuable commodity, so we strive to create a culture that reflects this. We won’t drag you through unnecessary meetings or email you at 7 PM on a Saturday. When we\'re at work, we\'re there to get things done, and when we\'re off, we\'re really off. Strong Communication.
We like well-written documents over PowerPoints, OKRs over vague mission statements, and weekly one-on-ones over yearly reviews. Writing First.
We have a "writing-first" culture. We believe that clarity of writing reflects clarity of thinking and that the benefits of well-written documentation in a scientific environment are innumerable: democratization of ideation and decision-making, increased reproducibility, quicker scaling and onboarding, and better company-wide alignment, to name a few. Growth.
As an early-stage startup, we value scientists with an independent, can-do attitude. The more hats you can wear, the better. Our job as employers is to put you in positive feedback loops so you can grow in the direction of your choosing.
#J-18808-Ljbffr