General Proximity
Scientist/Sr. Scientist, Medicinal Chemistry
General Proximity, San Francisco, California, United States, 94199
Scientist/Sr. Scientist, Medicinal Chemistry
General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs). Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades.
We are seeking a first-rate medicinal chemist to help us pioneer this uncharted frontier of drug discovery.
Overview We are seeking an experienced medicinal chemist with chemical biology training to be a founding member of our Chemistry/Drug Discovery Team. In this position, you will work with both our Chemistry and Platform Teams in the development of our core drug discovery technology and the generation of a completely novel class of therapeutics.
Responsibilities Your responsibilities will include: supervising synthetic efforts with our CROs, performing and analyzing in cellulo assays, designing and optimizing first-in-class bifunctional molecules, collaborating with our Drug Discovery and IP team on patent applications, providing input for mechanistic studies on lead drug molecules, and spearheading forays into new disease areas.
About You High Agency.
Initiative, independence, and self-accountability are some of our most valued traits.
Enthusiastic.
We love people who are excited about what they are doing and are generally attempting to build a high-energy team.
Intensity and Grit.
Early-stage startups are hard. Drug discovery is doubly so. We are looking for candidates who have a demonstrated ability to stick with complex problems for the long haul, with a team that has your back along the way.
Prosocial.
We are here to create life-saving medicines for the patients who need it most. You should be, too.
Qualifications & Nice-To-Haves
PhD in Medicinal Chemistry, Chemical Biology, Pharmacology, or related field.
Industry experience is desirable, but the ability to work hard and learn fast is more important to us.
Deep understanding of small-molecule drug discovery and its relationship to human disease.
Ability to work fluently at the interface of chemistry and biology.
Top-notch written and oral communication skills.
Experience and Skills
Designing, synthesizing, and optimizing induced proximity medicines (e.g. PROTACs or other IPMs)
Contributing to hit-to-lead and lead optimization studies
Medicinal chemistry optimizations: SAR, PK/PD, strong understanding of DMPK
Experience with chemical biology techniques such as mammalian cell culture and cell-based assays (e.g., cytotoxicity assays, transfections, stable cell line generation, co-immunoprecipitation), PPI assays (e.g., BRET, APEX/BioID, AlphaScreen), or strong experience in computational chemistry
Nice to have
Proficiency in HTS and phenotypic assay development
Computational or molecular dynamics drug discovery experience
DEL experience
Experience managing others, especially synthetic chemistry CRO teams
Prior experience on teams that have successfully advanced research to the clinic
Strong equity incentives and ownership of projects
Comprehensive benefits (medical, dental, vision) and wellness programs
Education and health/fitness incentive programs
Reading budget to support ongoing learning
Located in the Bay Area; convenient access to related facilities
About Us Work Hard/Play Hard.
We strive to create a culture that respects time and avoids unnecessary meetings. When we’re at work, we get things done; when we’re off, we’re really off.
Strong Communication.
We value well-written documents, clear objectives, and regular one-on-ones.
Writing First.
We prioritize clear writing to support ideation, reproducibility, and alignment.
Growth.
We value scientists with an independent, can-do attitude and welcome you to grow in the direction you choose.
Title and compensation commensurate with experience. Applications from diverse backgrounds are welcomed.
#J-18808-Ljbffr
We are seeking a first-rate medicinal chemist to help us pioneer this uncharted frontier of drug discovery.
Overview We are seeking an experienced medicinal chemist with chemical biology training to be a founding member of our Chemistry/Drug Discovery Team. In this position, you will work with both our Chemistry and Platform Teams in the development of our core drug discovery technology and the generation of a completely novel class of therapeutics.
Responsibilities Your responsibilities will include: supervising synthetic efforts with our CROs, performing and analyzing in cellulo assays, designing and optimizing first-in-class bifunctional molecules, collaborating with our Drug Discovery and IP team on patent applications, providing input for mechanistic studies on lead drug molecules, and spearheading forays into new disease areas.
About You High Agency.
Initiative, independence, and self-accountability are some of our most valued traits.
Enthusiastic.
We love people who are excited about what they are doing and are generally attempting to build a high-energy team.
Intensity and Grit.
Early-stage startups are hard. Drug discovery is doubly so. We are looking for candidates who have a demonstrated ability to stick with complex problems for the long haul, with a team that has your back along the way.
Prosocial.
We are here to create life-saving medicines for the patients who need it most. You should be, too.
Qualifications & Nice-To-Haves
PhD in Medicinal Chemistry, Chemical Biology, Pharmacology, or related field.
Industry experience is desirable, but the ability to work hard and learn fast is more important to us.
Deep understanding of small-molecule drug discovery and its relationship to human disease.
Ability to work fluently at the interface of chemistry and biology.
Top-notch written and oral communication skills.
Experience and Skills
Designing, synthesizing, and optimizing induced proximity medicines (e.g. PROTACs or other IPMs)
Contributing to hit-to-lead and lead optimization studies
Medicinal chemistry optimizations: SAR, PK/PD, strong understanding of DMPK
Experience with chemical biology techniques such as mammalian cell culture and cell-based assays (e.g., cytotoxicity assays, transfections, stable cell line generation, co-immunoprecipitation), PPI assays (e.g., BRET, APEX/BioID, AlphaScreen), or strong experience in computational chemistry
Nice to have
Proficiency in HTS and phenotypic assay development
Computational or molecular dynamics drug discovery experience
DEL experience
Experience managing others, especially synthetic chemistry CRO teams
Prior experience on teams that have successfully advanced research to the clinic
Strong equity incentives and ownership of projects
Comprehensive benefits (medical, dental, vision) and wellness programs
Education and health/fitness incentive programs
Reading budget to support ongoing learning
Located in the Bay Area; convenient access to related facilities
About Us Work Hard/Play Hard.
We strive to create a culture that respects time and avoids unnecessary meetings. When we’re at work, we get things done; when we’re off, we’re really off.
Strong Communication.
We value well-written documents, clear objectives, and regular one-on-ones.
Writing First.
We prioritize clear writing to support ideation, reproducibility, and alignment.
Growth.
We value scientists with an independent, can-do attitude and welcome you to grow in the direction you choose.
Title and compensation commensurate with experience. Applications from diverse backgrounds are welcomed.
#J-18808-Ljbffr