Eli Lilly and
Scientific Director – Virtual Screening Applications Expert
Eli Lilly and, San Diego, California, United States, 92189
Overview
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We put people first and seek individuals determined to make life better for people around the world. The Lilly Small Molecule Discovery group focuses on creating molecules that engage disease-relevant biological systems to test clinical hypotheses and advance innovative medicines. We aim to deliver molecules with breakthrough efficacy and high safety margins, optimize mindset, technology, and processes for faster execution, and empower innovative problem solving through open collaboration and accountability. Position Summary:
The Lilly Small Molecule Discovery (LSMD) organization creates and discovers new molecules to engage disease-relevant biological systems, test clinical hypotheses, and advance innovative medicines. To accelerate delivery of unique medicines and optimize research investment, innovative use of computational tools is integral. Lilly’s Early Molecule Discovery (EMD) team is responsible for small molecule hit-to-lead prosecution through the application of best-in-class and novel approaches to pre-portfolio targets. We seek an internationally recognized Virtual Screening (VS) Applications Expert who will be accountable for small molecule VS activities. The (Senior / Executive) Director will collaborate across the computational, structural biology and medicinal chemistry organizations within the EMD and beyond to drive the application of transformative VS approaches to bolster Lilly’s ability to prosecute difficult-to-drug targets. This is an on-site role. We are seeking a candidate who is willing to relocate to San Diego (CA), Indianapolis (IN) or Louisville (CO).
Responsibilities
Drive the VS @Lilly platform within a matrix organization. Collaborate with new targets and existing therapeutic project teams to ensure VS is used to rapidly identify attractive small molecule starting points for Hit-ID and multi-generational drug discovery across Lilly. Pioneer the introduction of transformative methods into the VS@Lilly platform and push the boundaries of VS to deliver a capability unrivaled in the pharma industry. Additional characteristics and attributes sought: Strategic and transformational thinking, with self-awareness Future-focused rather than tied to precedent Aptitude for building interdisciplinary bridges and developing inclusive teams Open, transparent communication with employees, team members and senior leadership Collaborative across teams, functions, departments and sites Proactive in establishing and driving internal and external collaborations Key Activities
Work with key stakeholders to drive the VS@Lilly matrix to extend Lilly’s lead by identifying novel chemical starting points to support new and multigenerational drug discovery across MOAs and targets Collaborate with structural biologists and modelers to leverage structural/biophysical data to prepare targets for VS campaigns Deliver workflows that leverage physics- and AI-based modelling to enrich VS true-positive hit rates on hard-to-drug targets Champion and implement cutting-edge methods, including ensemble or AI-based VS techniques Develop and implement cheminformatics tools to maximize chemical and binding pocket feature space coverage for hypothesis exploration Work with medicinal chemists to triage VS hits for synthesis/purchase Streamline VS workflows with Tech @Lilly to ensure timely impact and broader adoption Basic Qualifications
Ph.D. in Computational Chemistry, Computational Medicinal Chemistry or related field 5+ years’ experience applying VS technologies to drive drug discovery toward candidate identification and beyond Proven ability to champion new technologies and achieve successful applications Proven ability to inspire and lead scientists across teams, functions, departments and sites to accelerate portfolio deliveries Additional Skills/Preferences
Excellent interpersonal skills and advocacy of Diversity & Inclusion Passionate about coaching and developing others Extensive expertise with molecular design software tools Familiarity with medicinal chemistry and ADME concepts Authors on peer-reviewed publications and/or inventors on patents/patent applications Expertise in GPCR drug discovery Some domestic and international travel is anticipated Compliance, Diversity & Benefits
Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce and offers equal opportunities for applicants. If you require accommodation to submit a resume, please complete the accommodation request form for further assistance. Lilly is an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status. Our employee resource groups (ERGs) support diverse communities. Learn more about all of our groups. Actual compensation will depend on education, experience, skills, and location. The anticipated wage for this position is $184,500 - $270,600. Full-time employees are eligible for a company bonus and a comprehensive benefits program including 401(k), pension, health benefits, flexible benefits, life insurance, time off, and well-being programs. Lilly reserves the right to amend compensation and benefit programs as needed. #WeAreLilly
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At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We put people first and seek individuals determined to make life better for people around the world. The Lilly Small Molecule Discovery group focuses on creating molecules that engage disease-relevant biological systems to test clinical hypotheses and advance innovative medicines. We aim to deliver molecules with breakthrough efficacy and high safety margins, optimize mindset, technology, and processes for faster execution, and empower innovative problem solving through open collaboration and accountability. Position Summary:
The Lilly Small Molecule Discovery (LSMD) organization creates and discovers new molecules to engage disease-relevant biological systems, test clinical hypotheses, and advance innovative medicines. To accelerate delivery of unique medicines and optimize research investment, innovative use of computational tools is integral. Lilly’s Early Molecule Discovery (EMD) team is responsible for small molecule hit-to-lead prosecution through the application of best-in-class and novel approaches to pre-portfolio targets. We seek an internationally recognized Virtual Screening (VS) Applications Expert who will be accountable for small molecule VS activities. The (Senior / Executive) Director will collaborate across the computational, structural biology and medicinal chemistry organizations within the EMD and beyond to drive the application of transformative VS approaches to bolster Lilly’s ability to prosecute difficult-to-drug targets. This is an on-site role. We are seeking a candidate who is willing to relocate to San Diego (CA), Indianapolis (IN) or Louisville (CO).
Responsibilities
Drive the VS @Lilly platform within a matrix organization. Collaborate with new targets and existing therapeutic project teams to ensure VS is used to rapidly identify attractive small molecule starting points for Hit-ID and multi-generational drug discovery across Lilly. Pioneer the introduction of transformative methods into the VS@Lilly platform and push the boundaries of VS to deliver a capability unrivaled in the pharma industry. Additional characteristics and attributes sought: Strategic and transformational thinking, with self-awareness Future-focused rather than tied to precedent Aptitude for building interdisciplinary bridges and developing inclusive teams Open, transparent communication with employees, team members and senior leadership Collaborative across teams, functions, departments and sites Proactive in establishing and driving internal and external collaborations Key Activities
Work with key stakeholders to drive the VS@Lilly matrix to extend Lilly’s lead by identifying novel chemical starting points to support new and multigenerational drug discovery across MOAs and targets Collaborate with structural biologists and modelers to leverage structural/biophysical data to prepare targets for VS campaigns Deliver workflows that leverage physics- and AI-based modelling to enrich VS true-positive hit rates on hard-to-drug targets Champion and implement cutting-edge methods, including ensemble or AI-based VS techniques Develop and implement cheminformatics tools to maximize chemical and binding pocket feature space coverage for hypothesis exploration Work with medicinal chemists to triage VS hits for synthesis/purchase Streamline VS workflows with Tech @Lilly to ensure timely impact and broader adoption Basic Qualifications
Ph.D. in Computational Chemistry, Computational Medicinal Chemistry or related field 5+ years’ experience applying VS technologies to drive drug discovery toward candidate identification and beyond Proven ability to champion new technologies and achieve successful applications Proven ability to inspire and lead scientists across teams, functions, departments and sites to accelerate portfolio deliveries Additional Skills/Preferences
Excellent interpersonal skills and advocacy of Diversity & Inclusion Passionate about coaching and developing others Extensive expertise with molecular design software tools Familiarity with medicinal chemistry and ADME concepts Authors on peer-reviewed publications and/or inventors on patents/patent applications Expertise in GPCR drug discovery Some domestic and international travel is anticipated Compliance, Diversity & Benefits
Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce and offers equal opportunities for applicants. If you require accommodation to submit a resume, please complete the accommodation request form for further assistance. Lilly is an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status. Our employee resource groups (ERGs) support diverse communities. Learn more about all of our groups. Actual compensation will depend on education, experience, skills, and location. The anticipated wage for this position is $184,500 - $270,600. Full-time employees are eligible for a company bonus and a comprehensive benefits program including 401(k), pension, health benefits, flexible benefits, life insurance, time off, and well-being programs. Lilly reserves the right to amend compensation and benefit programs as needed. #WeAreLilly
#J-18808-Ljbffr