Arcinstitute
The Arc Institute is a new scientific institution conducting curiosity-driven basic science and technology development to understand and treat complex human diseases. Headquartered in Palo Alto, California, Arc is an independent research organization founded on the belief that many important research programs will be enabled by new institutional models. Arc operates in partnership with Stanford University, UCSF, and UC Berkeley.
While the prevailing university research model has yielded many tremendous successes, we believe in the importance of institutional experimentation as a way to make progress. These include:
Technology: Biomedical research has become increasingly dependent on complex tooling. Arc Technology Centers develop, optimize and deploy rapidly advancing experimental and computational technologies in collaboration with Core Investigators.
Support: Arc aims to provide first-class support—operationally, financially and scientifically—that will enable scientists to pursue long-term high risk, high reward research that can meaningfully advance progress in disease cures, including neurodegeneration, cancer, and immune dysfunction.
Funding: Arc fully funds Core Investigators’ (PIs’) research groups, liberating scientists from the typical constraints of project-based external grants.
Culture: We believe that culture matters enormously in science and that excellence is difficult to sustain. We aim to create a culture that is focused on scientific curiosity, a deep commitment to truth, broad ambition, and selfless collaboration.
Arc scaled to nearly 200 people in its first two years. With $650M+ in committed funding and a state of the art new lab facility in Palo Alto, Arc will continue to grow quickly to several hundred in the coming years.
About the position
Arc seeks an experienced Mass Spectroscopy Scientist to lead and strategically develop Arc's metabolomics and lipidomics research capabilities, defining the Institute's approach to mass spectrometry-enabled discovery. To succeed, you will need to be an enthusiastic team player, detail-oriented, organized and comfortable working on complex problems. The work will involve pursuing breakthrough opportunities in metabolomics / lipidomics that advance Arc's mission, while also enabling high-impact research across our labs and tech centers, working closely with our superusers and making sure all our instruments are in good working order. You will work with many different sample types, optimize and develop sample preparation and data acquisition and analysis methods, and be responsible for managing the Arc Mass Spec core facility. The position will involve driving metabolomics/lipidomics research projects as well as working closely with collaborators across labs at Arc and identifying and working with affiliated cores and outside CROs on MassSpec related collaborations.
About you
You thrive on collaboration and enjoy supporting our core labs and tech centers in curiosity-driven research.
You care a great deal about getting the highest data quality in metabolomics/lipidomics
You get excited about the possibilities that new metabolomics/lipidomics methods and equipment bring, and you love thinking about how they can fit into our current and future research.
Diving into the technical details to troubleshoot methods and instruments energizes you, and you're always eager to roll up your sleeves and do hands-on work.
In this position you will
Lead MassSpec method development projects for optimization and validation of protocols and methodologies in collaboration with Core Labs and Tech Centers. Apply standard and non-standard methods for multiple projects.
Work on both smaller scale projects with individual scientists as well as large-scale data generation with high throughput for our Institute initiatives.
Explore advances in mass spectrometry/metabolomics/lipidomics – especially in areas of minimizing sample input requirements and increasing throughput
Run benchmarking of relevant technologies and share insights with the Arc community via demos and presentations.
Maintain and troubleshoot mass spectrometers including TripleQ, Orbitrap and similar instruments. You must be comfortable performing hands-on troubleshooting and solving basic instrument problems as they arise.
Lead cross-institute initiatives that leverage metabolomics to address fundamental questions in biology.
Identify emerging opportunities where mass spectrometry can unlock new biological insights aligned with Institute goals.
Prepare samples from tissues, cells, and biofluids, optimize and develop new sample preparation and LC-MS methods for metabolites, lipids, small molecules and peptide profiling.
Run data analysis and interpretation of all data generated at the Mass Spec facility.
Assist and train laboratory personnel with respect to the use of mass spectrometry equipment and safety procedures.
Act as a shared point of contact with the manufacturer’s technical support and field service engineering teams to coordinate instrument preventative maintenance and repairs as needed.
Develop and evolve an equipment management program in concert with the Lab Ops team to minimize equipment downtime and maintain equipment service logs.
Monitor and manage the supply of all commonly required solvents, supplies and consumables.
Drive scientific discourse through presentations at major conferences, serve as a thought leader in the metabolomics community, and contribute to Arc's reputation as an innovation leader.
Requirements
PhD in biochemistry/chemistry/biology or related field plus a minimum of 5 years of relevant experience
5+ years of mass spec experience in an academic environment and/or industry, including direct experience with Agilent TripleQ and Thermofisher Orbitrap instruments. Additional experience with similar instruments is appreciated
Strong record of producing very high quality data as well as overall productivity and scientific publications
Experience in method development for mass spectrometry
Demonstrated ability to build and lead cross-functional scientific initiatives
Familiarity with metabolomics/lipidomics analysis software (Compound Discoverer, LipidSearch, Agilent Qualitative/Quantitative Analysis)
Strong background in bioinformatics tools or platforms for large-scale data analysis (R, Python, Matlab)
Experience in maintaining and troubleshooting HPLCs and mass spectrometers
Experience with derivatization techniques for poorly ionized and fragmented targets
Experience with diverse sample preparation strategies
Detail-oriented and organized
Strong teamwork and communication skills
Being self-motivated with a “can-do” attitude is required for success
Flexible and able to respond quickly to shifting priorities as well as multitask
Preferred Qualifications
Experience in spatial metabolomics/lipidomics
Experience in single cell metabolomics/lipidomics
Has experience with isotope tracer studies (ideally in vitro and in vivo)
Has experience with discovery metabolomics (characterizing unknown peaks/metabolites, etc)
The base salary range for this position is $121,250 to $150,000. These amounts reflect the range of base salary that the Institute reasonably would expect to pay a new hire or internal candidate for this position. The actual base compensation paid to any individual for this position may vary depending on factors such as experience, market conditions, education/training, skill level, and whether the compensation is internally equitable, and does not include bonuses, commissions, differential pay, other forms of compensation, or benefits. This position is also eligible to receive an annual discretionary bonus, with the amount dependent on individual and institute performance factors.
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* indicates a required field First Name * Last Name * Email * Phone Country Phone Resume/CV * Enter manually Accepted file types: pdf, doc, docx, txt, rtf Enter manually Accepted file types: pdf, doc, docx, txt, rtf LinkedIn Profile Website Are you currently authorized to work in the US? * Select... Will you now, or in the future, require employer visa sponsorship (e.g., H-1B)? * Select... Voluntary Self-Identification
For government reporting purposes, we ask candidates to respond to the below self-identification survey.Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiringprocess or thereafter. Any information that you do provide will be recorded and maintained in aconfidential file. As set forth in Arc Institute’s Equal Employment Opportunity policy,we do not discriminate on the basis of any protected group status under any applicable law. If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection.As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measurethe effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categoriesis as follows: A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability. A "recently separated veteran" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service. An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense. An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985. Select... Voluntary Self-Identification of Disability
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We are a federal contractor or subcontractor. The law requires us to provide equal employment opportunity to qualified people with disabilities. We have a goal of having at least 7% of our workers as people with disabilities. The law says we must measure our progress towards this goal. To do this, we must ask applicants and employees if they have a disability or have ever had one. People can become disabled, so we need to ask this question at least every five years. Completing this form is voluntary, and we hope that you will choose to do so. Your answer is confidential. No one who makes hiring decisions will see it. Your decision to complete the form and your answer will not harm you in any way. If you want to learn more about the law or this form, visit the U.S. Department of Labor’s Office of Federal Contract Compliance Programs (OFCCP) website at www.dol.gov/ofccp . How do you know if you have a disability?
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