ZipRecruiter
Research Scientist, Antibody Discovery and Research
ZipRecruiter, San Diego, California, United States, 92189
Overview
Research Scientist, Antibody Discovery and Research
Mapp Biopharmaceutical, Inc. ("Mapp") is a San Diego based, innovative biopharmaceutical company focused on addressing unmet medical needs through the development of life-saving monoclonal antibody treatment options to combat a variety of neglected and tropical infectious diseases, and in support of biodefense programs.
The Early Research and Development Group (ERDG) and the Advanced Research and Development Group (ARDG) at Mapp Biopharmaceutical are responsible for the execution of high quality Research and Development activities to ensure the achievement of a robust portfolio through CMC, Nonclinical, Regulatory, Project Management, and Clinical activities consistent with Mapp's product development objectives. The Research Scientist works in the antibody discovery group which is responsible for isolating novel antibodies that may be used in future drug products. This includes creating and producing the antigens necessary to isolate these antibodies and assessing the antibodies for their potential as therapeutics. The Research Scientist, Antibody Discovery and Research will provide overall support for our projects including design, execution, supervision, analysis and interpretation of results.
Responsibilities
Optimizes and designs expression constructs for protein stability, solubility and expression levels
Designs and optimizes strategies to generate and purify proteins of interest for subsequent in vitro and in vivo applications
Designs and develops novel in vitro assays to assess antibodies for binding and activity
Supervises research scientists at various levels as needed
Reviews and synthesize new research findings regularly
Maintains detailed records of all experiments performed
Presents and communicates effectively experimental results to the group
Basic Qualifications
PhD or equivalent in biology, molecular biology, biochemistry, virology, and/or related field
Post doc experience or other appropriate scientific experience
Author on scientific publications in respected peer reviewed journals
Demonstrated excellence in the following competency areas:
Protein expression in bacterial, mammalian and insect cell systems
Protein purification, including experience with automated HPLC and FPLC systems, fluency in GE Unicorn FPLC software
Flow cytometry and single B-cell sorting techniques
Experience in leading scientific personnel to execute against program deliverables
Experience with ForteBio Octet technology and isothermal titration calorimetry
Hands-on experience operating IncuCyte and similar high-content live-cell imaging systems
Experience effectively troubleshooting experimental strategies in the laboratory
Qualifications
Experience with primer design and RT-PCR particularly for monoclonal antibody isolation and cloning from single B-cells
Experience expressing and purifying viral proteins
Experience with reverse genetics and pseudo typed viral vector systems.
Command of in-silico workflows for antibody and protein engineering and optimization
Development of functional cell based assays/immunoassays to assess mechanism of action and potency of new antibody candidates (e.g. reporter assay, internalization assay, neutralization assay, shedding assay ADCC-assay, ADCP-assay, multi-flow etc.)
of stable cell lines using lentivirus transduction and validation of those cell lines via flow cytometry and western blot
Benefits and Additional Information
Salary range: $80,000 to $130,000 per year plus applicable bonuses. Final salary offered will depend on education and experience.
Medical, dental, and vision insurance benefits for eligible employees and their families.
Basic life insurance, short and long term disability, and a 401K plan with company contributions.
Paid time off: 7 sick days, 14 paid holidays, and 18 vacation days per year.
On-site position at Mapp's San Diego facility. Domestic travel approximately 2x/year and international travel approximately 1x/year will be required.
This position is on-site in Mapp's new state-of-the-art San Diego facility. Willingness to travel (domestic and international) is required.
Application and Status Mapp invites you to apply by submitting your information through the Mapp Biopharmaceutical, Inc. Job Openings website page. This job will remain open for twenty (20) days after posting.
No Solicitors, agents or placement agencies please. Mapp utilizes E-Verify.
Mapp is an equal opportunity employer and employment decisions are not based on any protected status. Mapp uses a wide variety of advertising and outreach to find qualified applicants for employment. Mapp is an Equal Opportunity Employer/Veterans/Disabled.
Job Posted by ApplicantPro
#J-18808-Ljbffr
Mapp Biopharmaceutical, Inc. ("Mapp") is a San Diego based, innovative biopharmaceutical company focused on addressing unmet medical needs through the development of life-saving monoclonal antibody treatment options to combat a variety of neglected and tropical infectious diseases, and in support of biodefense programs.
The Early Research and Development Group (ERDG) and the Advanced Research and Development Group (ARDG) at Mapp Biopharmaceutical are responsible for the execution of high quality Research and Development activities to ensure the achievement of a robust portfolio through CMC, Nonclinical, Regulatory, Project Management, and Clinical activities consistent with Mapp's product development objectives. The Research Scientist works in the antibody discovery group which is responsible for isolating novel antibodies that may be used in future drug products. This includes creating and producing the antigens necessary to isolate these antibodies and assessing the antibodies for their potential as therapeutics. The Research Scientist, Antibody Discovery and Research will provide overall support for our projects including design, execution, supervision, analysis and interpretation of results.
Responsibilities
Optimizes and designs expression constructs for protein stability, solubility and expression levels
Designs and optimizes strategies to generate and purify proteins of interest for subsequent in vitro and in vivo applications
Designs and develops novel in vitro assays to assess antibodies for binding and activity
Supervises research scientists at various levels as needed
Reviews and synthesize new research findings regularly
Maintains detailed records of all experiments performed
Presents and communicates effectively experimental results to the group
Basic Qualifications
PhD or equivalent in biology, molecular biology, biochemistry, virology, and/or related field
Post doc experience or other appropriate scientific experience
Author on scientific publications in respected peer reviewed journals
Demonstrated excellence in the following competency areas:
Protein expression in bacterial, mammalian and insect cell systems
Protein purification, including experience with automated HPLC and FPLC systems, fluency in GE Unicorn FPLC software
Flow cytometry and single B-cell sorting techniques
Experience in leading scientific personnel to execute against program deliverables
Experience with ForteBio Octet technology and isothermal titration calorimetry
Hands-on experience operating IncuCyte and similar high-content live-cell imaging systems
Experience effectively troubleshooting experimental strategies in the laboratory
Qualifications
Experience with primer design and RT-PCR particularly for monoclonal antibody isolation and cloning from single B-cells
Experience expressing and purifying viral proteins
Experience with reverse genetics and pseudo typed viral vector systems.
Command of in-silico workflows for antibody and protein engineering and optimization
Development of functional cell based assays/immunoassays to assess mechanism of action and potency of new antibody candidates (e.g. reporter assay, internalization assay, neutralization assay, shedding assay ADCC-assay, ADCP-assay, multi-flow etc.)
of stable cell lines using lentivirus transduction and validation of those cell lines via flow cytometry and western blot
Benefits and Additional Information
Salary range: $80,000 to $130,000 per year plus applicable bonuses. Final salary offered will depend on education and experience.
Medical, dental, and vision insurance benefits for eligible employees and their families.
Basic life insurance, short and long term disability, and a 401K plan with company contributions.
Paid time off: 7 sick days, 14 paid holidays, and 18 vacation days per year.
On-site position at Mapp's San Diego facility. Domestic travel approximately 2x/year and international travel approximately 1x/year will be required.
This position is on-site in Mapp's new state-of-the-art San Diego facility. Willingness to travel (domestic and international) is required.
Application and Status Mapp invites you to apply by submitting your information through the Mapp Biopharmaceutical, Inc. Job Openings website page. This job will remain open for twenty (20) days after posting.
No Solicitors, agents or placement agencies please. Mapp utilizes E-Verify.
Mapp is an equal opportunity employer and employment decisions are not based on any protected status. Mapp uses a wide variety of advertising and outreach to find qualified applicants for employment. Mapp is an Equal Opportunity Employer/Veterans/Disabled.
Job Posted by ApplicantPro
#J-18808-Ljbffr