Revolution Medicines
Senior Director, Clinical Development
Revolution Medicines, Redwood City, California, United States, 94061
Overview
Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway. The Opportunity
We are seeking an experienced clinical science drug developer to serve as Senior Director of Clinical Development in support of Revolution Medicines’ clinical-stage molecule(s). In this critical role, you will support various clinical science deliverables and enable effective and efficient execution of the clinical development plan for a molecule(s) within its particular indication(s). The scope of activities spans early-stage clinical research to pivotal studies including regulatory submissions. You will play a vital role in leading the clinical science aspects of the Clinical Development Plan (CDP) strategy, driving the development of transformative therapies for patients. Responsibilities
Lead clinical science aspects of the clinical development strategy and clinical documentation. Represent the clinical development plan on appropriate teams, sub-teams and forums; oversee training of study site personnel, act as primary point-of-contact for questions/enquiries regarding the CDP at a program level, oversee the conduct of medical/safety data reviews and study reporting. Potential assignment to complex and high-priority strategic studies for Revolution Medicines’ molecules, with expectation to perform responsibilities with independence and clear self-directed leadership. Cross-functionally align efforts seamlessly with scientific, regulatory, and commercial objects while executing upon the clinical development plan. Lead, mentor, and contribute to a high-performing cross-functional team of clinical development professionals, fostering a culture of collaboration, innovation, and excellence. Oversee all aspects of clinical trial design and execution, including site selection, patient recruitment, data management, and regulatory compliance. Establish and maintain strong relationships with clinical investigators, regulatory agencies, and key stakeholders. Gather, analyze and interpret clinical data, providing strategic insights to inform critical decisions and guide program development. Manage clinical development timelines effectively, ensuring efficient resource allocation and achievement of milestones. Stay abreast of the latest scientific advancements and regulatory trends in the field of clinical development. Qualifications
Bachelor’s Degree (life sciences preferred) plus Advanced Clinical/Science Degree is required (e.g., PharmD, PhD, MSN, MPH, etc.). Minimum 13+ years experience in clinical development required (Pharma R&D experience outside of a clinical development role also considered pending transferability of skills and responsibilities). Extensive experience with data analysis, interpretation, and clinical relevance in pharmaceutical/biotech. Experience in independent generation of trial design, protocol writing/ICF, constructing CRF and coordinating cross-functionally. In-depth therapeutic area experience and relevant clinical trial experience (or clear ability to adapt with transferable skills). Strong knowledge of medical aspects of GCP, ICH, FDA, EMA and other guidelines and regulations. Proven ability to work effectively within cross-functional teams and integrate multiple perspectives into the CDP. Experience authoring regulatory briefing packs and writing responses to Health Authority questions; ability to contribute to regulatory strategy and cross-functional coordination. Demonstrated success in driving cross-functional study-level strategy, including study design, feasibility, timelines and budget projections; ability to drive discussions at governance meetings. Ability to build and maintain relationships with external key opinion leaders (KOLs) and investigators to optimize clinical programs. Experience in investigator engagement to optimize trial conduct; includes presenting at investigator meetings. Strong leadership and communication skills; ability to mentor and inspire a diverse team. Experience or potential as an effective line manager. Strategic thinking with strong analytical skills and data-driven decision making; ability to set priorities. Strong written and business presentation skills. Passion for innovation and a commitment to developing therapies that improve patients’ lives. Demonstrated adaptability, flexibility, and stakeholder management. Preferred Skills
Contributed to clinical development plan conception, conduct and delivery, with alignment to scientific governance. Experience in ongoing enhancements of core and sub-team processes, structures, systems, tools, and resources. Led clinical development contributions to major regulatory submissions (e.g., sNDA/sBLA, PIP/PSP, label negotiation, Breakthrough Therapy Designation, Accelerated Review). Ability to present the clinical development aspects of a program to health authorities by teleconference or in-person. Led Health Authority interactions. Experience defining clinical development strategy for CTA/EC submissions and responses to health authority questions. Collaborative leadership across enterprise initiatives with internal and external partners; outcomes aligned with strategic goals. Influential and inspiring leader who can bring teams along. Demonstrated courage, conflict resolution skills, and strategic risk assessment. Compensation and Benefits
The base salary range for this full-time position is $236,000 to $295,000 for candidates onsite at our Redwood City, CA headquarters. Salary ranges are determined by role, level, and location and may be adjusted for the local market. Base salary is part of the total rewards package including equity, benefits, and development opportunities. Equal Opportunity
Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.
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Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway. The Opportunity
We are seeking an experienced clinical science drug developer to serve as Senior Director of Clinical Development in support of Revolution Medicines’ clinical-stage molecule(s). In this critical role, you will support various clinical science deliverables and enable effective and efficient execution of the clinical development plan for a molecule(s) within its particular indication(s). The scope of activities spans early-stage clinical research to pivotal studies including regulatory submissions. You will play a vital role in leading the clinical science aspects of the Clinical Development Plan (CDP) strategy, driving the development of transformative therapies for patients. Responsibilities
Lead clinical science aspects of the clinical development strategy and clinical documentation. Represent the clinical development plan on appropriate teams, sub-teams and forums; oversee training of study site personnel, act as primary point-of-contact for questions/enquiries regarding the CDP at a program level, oversee the conduct of medical/safety data reviews and study reporting. Potential assignment to complex and high-priority strategic studies for Revolution Medicines’ molecules, with expectation to perform responsibilities with independence and clear self-directed leadership. Cross-functionally align efforts seamlessly with scientific, regulatory, and commercial objects while executing upon the clinical development plan. Lead, mentor, and contribute to a high-performing cross-functional team of clinical development professionals, fostering a culture of collaboration, innovation, and excellence. Oversee all aspects of clinical trial design and execution, including site selection, patient recruitment, data management, and regulatory compliance. Establish and maintain strong relationships with clinical investigators, regulatory agencies, and key stakeholders. Gather, analyze and interpret clinical data, providing strategic insights to inform critical decisions and guide program development. Manage clinical development timelines effectively, ensuring efficient resource allocation and achievement of milestones. Stay abreast of the latest scientific advancements and regulatory trends in the field of clinical development. Qualifications
Bachelor’s Degree (life sciences preferred) plus Advanced Clinical/Science Degree is required (e.g., PharmD, PhD, MSN, MPH, etc.). Minimum 13+ years experience in clinical development required (Pharma R&D experience outside of a clinical development role also considered pending transferability of skills and responsibilities). Extensive experience with data analysis, interpretation, and clinical relevance in pharmaceutical/biotech. Experience in independent generation of trial design, protocol writing/ICF, constructing CRF and coordinating cross-functionally. In-depth therapeutic area experience and relevant clinical trial experience (or clear ability to adapt with transferable skills). Strong knowledge of medical aspects of GCP, ICH, FDA, EMA and other guidelines and regulations. Proven ability to work effectively within cross-functional teams and integrate multiple perspectives into the CDP. Experience authoring regulatory briefing packs and writing responses to Health Authority questions; ability to contribute to regulatory strategy and cross-functional coordination. Demonstrated success in driving cross-functional study-level strategy, including study design, feasibility, timelines and budget projections; ability to drive discussions at governance meetings. Ability to build and maintain relationships with external key opinion leaders (KOLs) and investigators to optimize clinical programs. Experience in investigator engagement to optimize trial conduct; includes presenting at investigator meetings. Strong leadership and communication skills; ability to mentor and inspire a diverse team. Experience or potential as an effective line manager. Strategic thinking with strong analytical skills and data-driven decision making; ability to set priorities. Strong written and business presentation skills. Passion for innovation and a commitment to developing therapies that improve patients’ lives. Demonstrated adaptability, flexibility, and stakeholder management. Preferred Skills
Contributed to clinical development plan conception, conduct and delivery, with alignment to scientific governance. Experience in ongoing enhancements of core and sub-team processes, structures, systems, tools, and resources. Led clinical development contributions to major regulatory submissions (e.g., sNDA/sBLA, PIP/PSP, label negotiation, Breakthrough Therapy Designation, Accelerated Review). Ability to present the clinical development aspects of a program to health authorities by teleconference or in-person. Led Health Authority interactions. Experience defining clinical development strategy for CTA/EC submissions and responses to health authority questions. Collaborative leadership across enterprise initiatives with internal and external partners; outcomes aligned with strategic goals. Influential and inspiring leader who can bring teams along. Demonstrated courage, conflict resolution skills, and strategic risk assessment. Compensation and Benefits
The base salary range for this full-time position is $236,000 to $295,000 for candidates onsite at our Redwood City, CA headquarters. Salary ranges are determined by role, level, and location and may be adjusted for the local market. Base salary is part of the total rewards package including equity, benefits, and development opportunities. Equal Opportunity
Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.
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