Scientist Mass Bio

The Company: AI Proteins is a Boston-based biotechnology company focused on the de novo design and engineering of miniprotein therapeutics. We combine cutting-edge computational protein design and artificial intelligence with synthetic biology and laboratory robotics to accelerate the creation of life-changing medicines. Position Summary: AI Proteins is seeking a scientist with mass spectrometry hands-on experience to lead the analytical efforts for the characterization of miniproteins and bioconjugates. This role gives the opportunity to own and shape the company’s mass spectrometry strategy, from initial reliance on contract research organizations (CROs) to building a best-in-class internal analytical function with the right instrumentation, workflows, and talent to meet evolving program needs. Responsibilities: Areas of specific responsibility and attention will include the following: Develop and manage analytical tools, focusing on mass spectrometry and chromatography-based techniques to characterize unknown impurities and degradation products derived from miniprotein manufacturing. Design, perform and interpret LC-MS, LC/MS/MS and LC-QTOF/MS workflows to characterize miniproteins conjugates (including metal loading), ADCs drug substances, and intermediates. Develop workflows and analysis of LC/MS and MS based quantitation methods for miniproteins in complex matrices to support preclinical pharmacokinetic studies in collaboration with pharmacology and DMPK teams. Stay at the forefront of technological advancements in mass spectrometry and other analytical technologies, integrating innovative solutions to enhance current workflows. Purchase, set-up, and maintain relevant equipment to build internal mass spectrometry capabilities based on company needs. Manage outsourced analytical projects with CROs, ensuring scientific quality, appropriate study design, and timely delivery of actionable data. Prepare internal reports, presentations, protocols and technical documents for internal use and conferences. Participate in internal team meetings by actively engaging in scientific and technical discussions. Requirements: Ph.D., M.S., or B.S. in Biochemistry, Biotechnology, Chemistry, or related field with relevant experience in mass spectrometry, bioconjugation, or chemical biology. We look for a strong track record of success and high technical aptitude in the development of analytical assays powered by mass spectrometry. Preferred Qualifications: Expertise on characterization and determination of post-translational modification in recombinant proteins using LC/MS and LC/MS/MS. Experience in characterization of bioconjugates, including metal-containing conjugates or peptide-toxin conjugates using LC/MS, LC-QTOF/MS and ICP/MS. Demonstrated experience supporting bioanalytical studies, including preclinical pharmacokinetic and matrix stability analyses is a must. EEO Statement: AI Proteins, Inc. provides equal employment opportunities to all employees and applicants without regard to race, color, religious creed, sex, national origin, ancestry, citizenship status, pregnancy, childbirth, physical disability, mental disability, age, military status or status as a Vietnam-era or special disabled veteran, marital status, registered domestic partner or civil union status, gender (including sex stereotyping and gender identity or expression), medical condition, genetic information or sexual orientation in accordance with applicable federal and state laws.

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